DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	504	Identity:	151/504 - (29%)
Similarity:	249/504 - (49%)	Gaps:	52/504 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP---------------FSLAKEKLGSNYKEIVIPQYDFWPE 87
            ||:|....|:.||.::|||||.:.|               |........::..||:     |...
Mouse    34 SHWMNIKIILDELKQKGHEVTVLRPSTSIFLDPKKSPGLKFETFPTSFSNDVMEII-----FAKA 93

  Fly    88 IKEMT---NKNTVLEMTDLPTFAFLRMVNVMGIHTTDFAL-------EQPEIQAVINEKNKIGKY 142
            ::..|   .::|.|..:.|       :.|:...: :|:.|       ...::.|.:.|    .|:
Mouse    94 VERWTYEVPRDTCLSYSPL-------LQNIFDEY-SDYCLTLCKDTVSNKQLMAKLQE----SKF 146

  Fly   143 DLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLF-GVVSPWSYVPHAYMPYTDRMTLWE 206
            |::|::.....|.|| ..|.|||.:....|....:|.:.. |:..|.||||......:.:||..|
Mouse   147 DVILSDAIGPCGELI-AELLQIPFLYSLRFSPGYYLEKYSGGLPLPPSYVPVILSGLSGQMTFKE 210

  Fly   207 RIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPM 271
            |:.|:...    |..:|.:...::....:.:|:.|.|..|:.|........|:.||..|....|.
Mouse   211 RVKNMICM----LYFDFWFQTFREKKWDQFYSETLGRPTTLIETMGKAEMWLIRSYWDLEFPHPT 271

  Fly   272 AYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ 335
            ..|:..|||:|.:|.|.||:.::.|:..: .||.:.|||||.|  :::..||..........:.|
Mouse   272 LPNVYYVGGVHCKPAKPLPKEMEDFVQSSGEHGVVVFSLGSMV--SNMTEEKANAIAWALAQIPQ 334

  Fly   336 RVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCD 400
            :|||:|:.::...|..|.::..||||.|:|.||..|.||.|||..|..||:::|:|::|:|::.:
Mouse   335 KVLWRFDGKTPATLGPNTRIYKWLPQNDLLGHPKTKAFITHGGANGLYEAIHHGIPMIGIPLFGE 399

  Fly   401 QHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYW 465
            ||.||....:...|:.|:.|.::..:|...|.|:|:||.|:.|....|.|..|:|:..:|.|::|
Mouse   400 QHDNIAHMVAKGAAVTLNIRTMSRSDLLNALEEVIDNPFYKENAMWLSTIHHDQPMKPLDRAVFW 464

  Fly   466 INYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILIC 514
            |.:|:.|:||.||.....:|.|||::.||::|..||.:.. ||.||:.|
Mouse   465 IEFVMRHKGAKHLRPLAYNLTWYQYHSLDVIGFLLAFVTF-IVALIVKC 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/501 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	151/504 (30%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	146/496 (29%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	151/504 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840777
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690