DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	493	Identity:	143/493 - (29%)
Similarity:	242/493 - (49%)	Gaps:	49/493 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMT 101
            :||..:...:...|.::||....:  .|..::...||:..:     ..:|.|...|..:..|:..
Mouse    32 ESHLYIFKTLASALHERGHHTVLL--LSEGRDIAPSNHYSL-----QRYPGIFNSTTSDAFLQSK 89

  Fly   102 DLPTFA----FLRMVNVMGIHTTDFAL---EQPEIQAVINEKNKIGKYDLLLAEQFFNE-GALIL 158
            ....|:    .:.:|:::..:|.:..:   .|..||.:..|     |:||||.:.  |: ...::
Mouse    90 MRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKE-----KFDLLLVDP--NDMCGFVI 147

  Fly   159 GHLYQIPTITISTFGNANHLSQLF-----GVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAED 218
            .||..:.....||        .|:     |..:|.:|||......||||...||:.|..:.....
Mouse   148 AHLLGVKYAVFST--------GLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISR 204

  Fly   219 LVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHI 283
            :...|...|..:.:::|:  .||. ..::.:|....|..:|.:.:.|...||...|::.|||:..
Mouse   205 IGVSFLVLPKYERIMQKY--NLLP-AKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILT 266

  Fly   284 QPPKALPEHLQKFLDGA-THGAIYFSLGSQVR--SADLPPEKLKVFLEVFGSLKQRVLWKFEDES 345
            :|...|||.||:::.|| .||.:..|.|:.|:  |.|: ..||...|   |.|.|:|:|:|....
Mouse   267 KPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSEDI-ANKLAGAL---GRLPQKVIWRFSGTK 327

  Fly   346 LPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKS 410
            ..||..|.|:..||||.|:|.|.|::.|::||||....|.:|:|||::|:|::.|.:..:.:.::
Mouse   328 PKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQA 392

  Fly   411 AEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGA 475
            ....:.|::..||..||...|:::|.||.||...:|.|.|.:|:|...::...|||:|::.|.||
Mouse   393 KGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGA 457

  Fly   476 PHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILI 513
            .||.:|...:.:.|::||||.    .|:||..|:|..|
Mouse   458 RHLRSAVHQISFCQYFLLDIA----FVLLLGAVLLYFI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	142/491 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	143/492 (29%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	143/493 (29%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840816
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790