DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	137/552 - (24%)
Similarity:	241/552 - (43%)	Gaps:	85/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN 73
            :|.:|::|                    :||....|..|:.|:.:||.|..:  .:...|.:...
Worm    20 LFYVSVIA--------------------QSHIPFHNTAIKVLLDRGHTVDLV--IAQLNEMVKLK 62

  Fly    74 YKEIVIPQYDFWPEIKEMTNKNT-----VLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVI 133
            :...|...|.|..|......||.     :.....:|...||.. :.|..:..:..::.|.:...|
Worm    63 FPNGVGKNYTFGYEDPNFYRKNAGHLSDIFVEKPIPMAEFLTF-DDMTFNLCETVVKDPNLLNYI 126

  Fly   134 NEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHL-SQLF-------GVVSPWSY 190
                |.|.||:.|:.. ::..|.||.|...:|:       .|:.: :.||       |:.||.|.
Worm   127 ----KQGNYDIGLSSD-YDPCANILMHAGGVPS-------KASMVPTPLFQPQIVSAGLPSPASV 179

  Fly   191 VPHAYMPYTDRMTLWERIGNVAMSAAEDLVRE-FSYYPGQDAVLKKHFSKLLD----RVPTIKEL 250
            ......|..|. :.:.|:.:        |:|. ::.|.....:::|:.:.||:    ..|:.:|:
Worm   180 YGTVLYPKGDD-SFFNRLFH--------LIRHTYNIYFVAPRLMEKYNNLLLETFGPTFPSAEEI 235

  Fly   251 ERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSLGSQVRS 315
            |||:..||:||...:...||:::.:..:||:..:..:.|.:.....|..:..|.:.||.|:||.:
Worm   236 ERNVDIILVNSNEIIEKPRPVSHKIKYIGGMGKKKAQPLNKEFNDILATSNKGVVLFSFGTQVAT 300

  Fly   316 ADLPPEKLKVFLEVFGSLKQ-RVLWKF----EDESLPNLPANVKVQSWLPQGDILAHPNVKVFIA 375
            :.:|.|..|.|:..|..... ..|||:    :|..|....:|:....||||.|:|....||.||:
Worm   301 SKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADSSNIHRVEWLPQTDLLGDNRVKAFIS 365

  Fly   376 HGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKY 440
            |.||....|....|:|:|.:|::.||..|.....|.:..:.::..::|||.|...|.:|:.||||
Worm   366 HMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVERHQLTVENLVNALQKLLYNPKY 430

  Fly   441 RNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLV-AAGVHLPWYQFYLLDIVGLGLAVIL 504
            ..|.|..|::..::|..:....:.|:.|..::.|...:: ..|..|..:.:|.:|::   |.|:|
Worm   431 GENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGAELTPFWYYSVDVI---LIVVL 492

  Fly   505 LPIVVLILI--------CR------RSSKPKS 522
            .....||:|        |:      ||.:|||
Worm   493 SLTSSLIIIWKTLSFIKCQISIRSVRSIEPKS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	130/527 (25%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	128/508 (25%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	126/498 (25%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	80/282 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810