DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-13

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504317.2	Gene:	ugt-13 / 186766	WormBaseID:	WBGene00019232	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	137/550 - (24%)
Similarity:	235/550 - (42%)	Gaps:	66/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKSALHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSL 65
            |..|.||:..|:|.|:.:.:      .|....|  |.||....:.:...:...||.||...|:.:
Worm     1 MYFKLALYCLLISFVSSKNI------LIYDPIF--GFSHVKFVSLMAEIIANHGHNVTLFRPYHI 57

  Fly    66 AKEKLGSNYKEIVIPQYDFWPE-IKEMTNKNTVLEMTDLPTF--------AFLRMVNVMGIHTTD 121
            |...:....|...|...|::|: ..|:.:    .|....|.|        ..||.:.|..:.:.:
Worm    58 ALPNVDGLVKNKNIQIIDYFPKHYDELLH----AEKQTFPGFWNDPLISQPVLRSLVVSKLISGE 118

  Fly   122 F---ALEQPEIQAVINE-KNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLF 182
            .   |.:..:.:.|:|| ::|  |:|::::|.|...| |.|.|:..:|.|.:........|..|.
Worm   119 MKRTATQLLQDERVLNELRSK--KFDVVISETFEITG-LYLAHIIDVPCIPMMPAVRYLDLGYLL 180

  Fly   183 GVVSPWSYVPHAYMPYTDRMTLWERIGNV----AMSAAEDLVREFSYYPGQDAVLKKHFSKLLDR 243
            |..|...|...............:|:.:|    .||...|...::.         ..:....:.|
Worm   181 GQPSLIGYAQQPGSKMAPEAGFLDRLNDVYQYFFMSCETDWTSQYQ---------NDNIEAAIGR 236

  Fly   244 -VPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPK-----ALPEHLQKFLDGATH 302
             :|..|:|.||....:|||...|..:.|....::.|||:.:...|     .|.|..:..|....:
Worm   237 PLPNWKDLLRNSPIYILNSNPYLDFAVPTTATIVQVGGMTVDLKKMKNVAKLSEEYETILAERDY 301

  Fly   303 GAIYFSLGSQVRSADLPPEKLKV-FLEVFGSLKQ-RVLWKFED---ESLPNLPANVKVQSWLPQG 362
             |:..|.||.:||..: |:..|| .:::|.||.. ..:||:|.   |....||.||.::.|:||.
Worm   302 -AVLISFGSVIRSFQM-PDNFKVGLIKLFESLSDVTFIWKYEKGDVEFQKRLPKNVHLKKWVPQP 364

  Fly   363 DILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTV--- 424
            .:||...||:|:.||||..|.|..|.|.|.|.:|::.||..|.:.  .|.:...:.|.|..:
Worm   365 SLLADKRVKLFVTHGGLGSTTEVAYTGKPALMVPIFGDQPNNADM--LARHGGAIAYSKFDLANG 427

  Fly   425 EELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIE---HRG-APHLVAAGVHL 485
            |:|...:.:::.||||:...:....:..::|:...:..|..:.:.::   ||. .|.:..||:..
Worm   428 EKLANTVKDMVFNPKYKEKAELLFDVLSNQPIDPKENFIKHLEFAMKFPNHRSQVPAVNQAGLIA 492

  Fly   486 PWYQFYLLDIVGLGLAVILLPIVVLILICR 515
               |:||..||...:..::...:..:.:||
Worm   493 ---QYYLDVIVFFVMISLISSYLSFVALCR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	132/540 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	125/511 (24%)
ugt-13	NP_504317.2	egt	1..509	CDD:223071	135/538 (25%)
ugt-13	NP_504317.2	UDPGT	29..514	CDD:278624	125/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740