DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-42

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	124/556 - (22%)
Similarity:	225/556 - (40%)	Gaps:	94/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLG 71
            :.:||:|.::      |....:::..|  |.||......:...|.:.||.||.::....:|.: .
Worm     8 IFVFLISNIS------GFNYLVVSPAF--GHSHSTFMGKLADALTEAGHNVTVLSIIVSSKFR-N 63

  Fly    72 SNY----KEIVIPQ--------------YDF---WPEIKEMTNKNTVLEMTDLPTFAFLRMVNVM 115
            .:|    |:||:.:              .||   |      |.:.|:||  .:|::.....::..
Worm    64 ISYTKLTKDIVVVETTNEQDQQAENMENNDFSRYW------TQEGTLLE--TIPSYLMFTKMSDH 120

  Fly   116 GIHT-TDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPT-ITISTFGNANHL 178
            |..| .:.||.|.|..     |:...:||.:..|.:.:.|..|..:| :||. :.:::..:...|
Worm   121 GYETFRNHALPQMEYL-----KSHRPRYDAVFFESYLHTGKAIQEYL-EIPVFLPVTSLTHDYRL 179

  Fly   179 SQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLD 242
            ::|.| .||| ||:...:..:          ||: |:..|.::...|||..|..:...::..|.|
Worm   180 AELIGEPVSP-SYLSGYFTNF----------GNI-MNFQERVINTLSYYLAQILISSPNWKTLQD 232

  Fly   243 ------------RVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQ----PPKALPE 291
                        |.|          .:.:||...:...||:....|.:||:.:.    ..:.:.|
Worm   233 PSKDLLVESEYYRAP----------YVFINSNPYIDFPRPLLSKTIEIGGITVDADALKSEKVDE 287

  Fly   292 HLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDE--SLPNLPANV 353
            .....|....|. :..|.|:..:|..:|.......::|..|.|. ..:||:|.|  |..|...|:
Worm   288 TWNNILKRRPHN-VLISFGTMFKSIHMPDSYKNNMVKVMKSFKNVTFIWKYESEETSFANGAENI 351

  Fly   354 KVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLD 418
            ..:.|.||..:||...:..|..||||....|..|.|.|.|..|::.||.:|...  .:.:...::
Worm   352 IFKKWTPQTALLADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKM--LSRHNGSIE 414

  Fly   419 YRKVTVEE---LRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVA 480
            ..|..:|.   ||..|..::.:..|..|.:|.::....:|....:..:....:.......|.|..
Worm   415 ISKFNLESYNTLRSALHSILFDESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARFGEQPALDC 479

  Fly   481 AGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRR 516
            ....:.:..::|||:|....:.::|.|:.|::|.|:
Worm   480 NLRTMGFATYHLLDVVVCLTSFVVLVILSLVVIIRK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	122/551 (22%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	117/522 (22%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	117/534 (22%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	114/514 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740