DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-41

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504818.2	Gene:	ugt-41 / 184295	WormBaseID:	WBGene00017336	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	134/563 - (23%)
Similarity:	231/563 - (41%)	Gaps:	81/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK-- 69
            |.|.||.::::.... |....:::..|  |.||......:...|.:.||.||.::....:|.:
Worm     3 LLIILLLVLSISNTS-GFNYLVVSPAF--GHSHSTFMGKLADSLTEAGHNVTVLSIIISSKFRNI 64

  Fly    70 -LGSNYKEIVIPQY--------------DF---WPEIKEMTNKNTVLEMTDLPTF-AFLRMVNVM 115
             ...:.|:||:.:.              ||   |      |.:.|:||  .:|:: .||:|.. .
Worm    65 SYTKSTKDIVVVETTTEQDQLTENMENDDFARYW------TQEGTMLE--TIPSYLMFLKMAE-D 120

  Fly   116 GIHT-TDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPT-ITISTFGNANHL 178
            |..| .|.||.|.:..     ||...:||.:..|.||..|..|..:| :||. :.:::..:....
Worm   121 GYKTFRDHALPQMDYL-----KNNRPQYDAVFFESFFFMGKAIQEYL-EIPVFLPVTSITHDYRF 179

  Fly   179 SQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLD 242
            ::|.| .||| ||:...:..:.:.|...||:.|.           .|||.||..:...::..|.|
Worm   180 AELIGEPVSP-SYLSGYFTNFGNIMNFQERLTNT-----------ISYYLGQILIAFPNWKTLQD 232

  Fly   243 RVPT----IKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQK----FLDG 299
              |:    ::........:.:||...:...||:....|.:||:.:...|...|.:.:    .|..
Worm   233 --PSKDLLVESEYHRAPYVFINSNPYIDFPRPLLSKTIEIGGITVDVKKLKSEKVDEKWDNILKK 295

  Fly   300 ATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDE--SLPNLPANVKVQSWLPQ 361
            ..|. :..|.||..:|..:|....:..::|..|.|. ..:||:|.|  |..|...|:....|:||
Worm   296 RPHN-VLISFGSMFKSIYMPDFYKENMVKVMKSFKNVSFIWKYESEETSFANGAENIIFSKWVPQ 359

  Fly   362 GDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEE 426
            ..:||...:..|..||||....|..|.|.|.|..|::.||.:|...  ...:...::..|..:|.
Worm   360 TALLADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQIRNSKM--LTRHNGSIEISKFNLEN 422

  Fly   427 ---LRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAP----HLVAAGVH 484
               ||..|..::....|..|.:|.::....:|....:..:....:.......|    :|...|
Worm   423 YNTLRSALHSILFAESYSENAEKLAKKLEYQPTKPKELFVRHAEFAARFGEQPAQDSNLRTMG-- 485

  Fly   485 LPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKK 527
              :..:||||::....:.:||.|.|:.::.|:..|..:..:|:
Worm   486 --FAAYYLLDVIAFLTSFVLLVIFVVFIMIRQIVKLLTIKSKR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	131/547 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	124/518 (24%)
ugt-41	NP_504818.2	UDPGT	22..510	CDD:278624	126/525 (24%)
ugt-41	NP_504818.2	Glycosyltransferase_GTB_type	26..512	CDD:299143	126/523 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740