DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-40

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	124/558 - (22%)
Similarity:	222/558 - (39%)	Gaps:	97/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALHIFLLSLVALQQLELGTGSRILAAFFFP--GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKE 68
            :|:::.|.|::..     |...||.  |.|  |.||......:...|.:.||.||..:| ::..|
Worm     5 SLYLYYLLLISST-----TSYNILV--FCPLFGHSHSTFFGRLADILTEAGHNVTLFSP-TIIDE 61

  Fly    69 KLGSNYKEIV--IPQYDFWPEIKEM-----TNK---NTVLEMTDLPTFAFLRMVNVMGIHTTDFA 123
            ....:|.::.  :...|..||:|.:     .||   |....:.::|             .||.|
Worm    62 FRNYSYTKLTKDVAYLDPSPELKAIGDLIAGNKRWWNQEFSVFEIP-------------QTTRF- 112

  Fly   124 LEQPEIQAVINEKNKI-------------GKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNA 175
                 .:::..|:|.:             .|:||:|.|..|.....::.:|      .|.:|..|
Worm   113 -----FKSITREQNNVLANNLALLDGLKQKKFDLILFESVFTCALPLMEYL------EIKSFAVA 166

  Fly   176 NHLSQ------LFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLK 234
            ..::.      ..|.....|::|:.....:|:|:|.||:.|..:.|..::.       |......
Worm   167 QSIAYEPITLGALGDTVMTSHIPNLMAQSSDKMSLCERMLNTLIQAMLNVY-------GMTPEYY 224

  Fly   235 KHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHI-----QPPKALPEHLQ 294
            :.::....::.|:::|. ..|.|.:||...|...|......|.:||:.:     :....|.|...
Worm   225 QSYTNPEKKIYTLEKLS-EASFIFMNSNPFLDFPRATITKNIQIGGISVNLDTLKSSGKLTEEWD 288

  Fly   295 KFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ----RVLWKFEDE---SLPNLPAN 352
            :.|: .....:..|.||.:.|.|: |...||.|.  .::||    ..:||:|.:   ...|...|
Worm   289 QILN-LREKTLLVSFGSVILSQDM-PFAYKVGLT--NAMKQLNDVTFIWKYEGDDKKEFANGIKN 349

  Fly   353 VKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNI----NQGKSAEY 413
            :....|:||.::||.|.:..|:.||||....|..|.|.|.:..|:..||.:|.    ....|.|:
Worm   350 IHFSKWVPQRELLADPRLSAFMTHGGLGSVNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEF 414

  Fly   414 A-LGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPH 477
            : ..|...||.....|.:|.:    ..|..:.|:.|...:.:|:...:..:..:.:.......|.
Worm   415 SKYDLHNEKVVANAFRKILYD----ESYTLSAKRLSEHLQFQPVKPKELFLKHVEFAARFGKLPS 475

  Fly   478 LVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICR 515
            |......:.:.|::|:||..:.|.|:|..:.||..:.:
Worm   476 LDPYSRQMGFIQYFLIDIAFIVLTVVLTIVSVLYFVLK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	124/553 (22%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	115/522 (22%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	107/468 (23%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	64/263 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740