DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-63

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504369.1	Gene:	ugt-63 / 182223	WormBaseID:	WBGene00015449	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	115/552 - (20%)
Similarity:	211/552 - (38%)	Gaps:	94/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HIFLLSLVAL--QQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKL 70
            |.|.:..:|.  ..|:....:|.|......|:||....|..:..|.|..|  |....|:..::.:
Worm     5 HDFHMRFIAFFATFLKHAEAARALLTVMDQGRSHATSINTFMHRLQKDNH--TTALEFAHFRQDI 67

  Fly    71 GSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVM--------GIHTTDFALE-- 125
            .....|..|          :|:......|..|....||....:.:        |..|.:..|:
Worm    68 DFGMDERFI----------DMSGFQNPFESPDFDKIAFEEDYSFIHQAVAYGFGSQTCNNILKHR 122

  Fly   126 QPEIQAVINEKNKIGKYDLLLAEQFFNEGALILG----------HLYQIPTITISTFGNANHLSQ 180
            :.....::.|     .:|:.|::..|    .|.|          |:....|...:..|:....|:
Worm   123 RERFFEILYE-----DWDIYLSDSLF----AICGYGMAEISGKPHVMMHSTDLEAAQGSFKGFSR 178

  Fly   181 LFGVVSPWSYVPHAYMPYTDR---MTLWER------------IGNVAMSAAEDLVREFSYYPGQD 230
            .:....| |.:|.:.:.||..   ..:|..            :||.|...|...:..|.|:
Worm   179 NYATFVP-SNLPFSMLNYTVSNYYHRVWAAYDWFGSFIFTAYVGNFAQKWALRSIIPFPYF---- 238

  Fly   231 AVLKKHFSKLLDRVPTIKELERNIS---AILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEH 292
                           :..|..|..|   ..:.:|..|.||   ...:....|....:..|.|...
Worm   239 ---------------SFAEYNRRSSFTFTDMPDSLFPPAS---RTNDFFSFGAYCKESSKPLDLE 285

  Fly   293 LQKFLD-GATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDESLPNLPANVKV 355
            .:.|:: ..:.|.|..:.|:.:.....|......|..|...|.: |::|..:.|..|.|..:||.
Worm   286 FKTFIEHPKSKGTILIAFGTFIDWRKAPKNYYDAFATVVNRLSEYRIIWSMKGERPPGLKKHVKT 350

  Fly   356 QSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYR 420
            .||:||..||.|....:|::||||..|:|.:.:..|.:.:|::.:|.:|....|...:|..::..
Worm   351 SSWVPQNQILHHNKTVLFLSHGGLKSTKEVICSATPTIFVPMFGEQTRNAWLIKEKGFARIMNKF 415

  Fly   421 KVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRG--APHLVAAGV 483
            |:.|:||...:.|::|:|.|:.|..|....:.|:|:..:|...:..|.::::.|  ..|.....:
Worm   416 KINVDELDTHMREVLEHPNYQQNANKFLTYYMDQPIPTLDEGAFKFNRLVKYGGKMPSHFYPKSL 480

  Fly   484 HLPWYQFYLLDIVGLGLAVILLPIVVLILICR 515
            .|.::....:|:      :|::||::|.|:.:
Worm   481 DLSYFTVLNVDL------LIVVPIMMLYLVLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	114/548 (21%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	108/518 (21%)
ugt-63	NP_504369.1	Glycosyltransferase_GTB_type	<276..500	CDD:299143	58/229 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940