DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-23

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001076755.1	Gene:	ugt-23 / 181205	WormBaseID:	WBGene00007650	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	147/550 - (26%)
Similarity:	238/550 - (43%)	Gaps:	54/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQL-ELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK----L 70
            |||.:.||.| .:.:..:||......|.||.....:::..||..||:||.:.|...:.:|    :
Worm     3 LLSALLLQILFNVSSPYKILVYSNLFGHSHIKFVGSVVDTLVDAGHDVTVVLPVIDSTQKNRTSI 67

  Fly    71 GSNYKEIVIPQYDFWPEIKEMTNK----NTVLEMTDLPTFAFLR---MVNVMGIHTTDFALEQPE 128
            .|..|:|:|...:...||...|.|    ...:||:: |...::.   :..:.|...|. .::..|
Worm    68 KSGAKQIIIDADEEVVEIFSQTEKFLSNMWTMEMSN-PLMMWMNPRILTQLFGKQCTK-VMKLSE 130

  Fly   129 IQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPT-ITISTFGNANHLSQLFGVVSPWSYVP 192
            :.    ::.|..|:||.:.|.|.:.|..|..:| |||. ::|.:....:|:|.:.|.....||||
Worm   131 LL----DQLKSEKFDLAITEAFDSCGYGIFEYL-QIPAHVSILSCARMDHVSDVLGQPIAPSYVP 190

  Fly   193 HAYMPYTDRMTLWERI--------GNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKE 249
            .....|:||||:.:|.        ||...|...|       |...:|      .|||....:.:|
Worm   191 GTQSLYSDRMTMTQRFLNYLQFLNGNSMFSDIGD-------YESANA------KKLLGVERSWRE 242

  Fly   250 LERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKAL--PEHLQKFLDGATHGAIYFSLGSQ 312
            :....|.:|.|....|....|....::|:||:.:...|..  .||....:.......:..|.||.
Worm   243 ILPESSFLLTNHIPVLEFPAPTFDKIVPIGGISVNKNKETLKLEHYFDTMVSMRKKNVIISFGSN 307

  Fly   313 VRSADLPPEKLKVFLEVFGSLKQ-RVLWKFE---DESLPNLPANVKVQSWLPQGDILAHPNVKVF 373
            ::|.|:|.|..|...|:|..:.. ..:||:|   |:.......|:....|:||.::||...|..|
Worm   308 IKSMDMPDEYKKSLAELFQLMPDVTFIWKYENLADKKYTCGIMNINRVEWIPQTELLADSRVDAF 372

  Fly   374 IAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGK---SAEYALGLDYRKVTVEELRGLLMELI 435
            |.||||....|....|.|.:.:|::.||.:|....|   .||.....|.  ...|.||..|.:::
Worm   373 ITHGGLGSVTELATMGKPAVVIPIFADQTRNAEMLKRHGGAEVLHKTDL--ANPETLRKTLRKVM 435

  Fly   436 ENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGL 500
            ::|.||.|.::.:.:..::|....:|.:..:.:.......|.:...|.|....::|.|||  |.:
Worm   436 DDPSYRQNAQRLAEMLNNQPTNPKETLVKHVEFAARFGKLPSMDPYGRHQNIIEYYNLDI--LAI 498

  Fly   501 AVILLPIVVLILICRRSSKPKSTPTKKKTK 530
            |.|||.:||.:.|.......:....|||.|
Worm   499 ATILLTLVVYLKIFAVGVVVRCCCGKKKVK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	142/531 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	134/505 (27%)
ugt-23	NP_001076755.1	UDPGT	20..526	CDD:278624	138/529 (26%)
ugt-23	NP_001076755.1	Glycosyltransferase_GTB_type	40..474	CDD:299143	117/455 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860