DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-18

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	136/512 - (26%)
Similarity:	229/512 - (44%)	Gaps:	63/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK--LGS-NYKEIVIPQYD------FWPEIKEM 91
            |.||......|...|:..||.||.:.|..|..:|  :|| ..|::|....|      |..|..|.
Worm    28 GASHSNFLGKISDILIDAGHNVTMLIPEYLITKKDFVGSKKVKDVVRIGRDERAGKLFEEEGIEH 92

  Fly    92 TNKNTVLEMTDLPTFAFLRMVNVMGI---HTTDFALEQPE-IQAVINEKNKIGKYDLLLAEQFFN 152
            ..:..|..| |....:.:.:|..|.:   :..::..:|.: |..:.||     .:||.:.|..|.
Worm    93 MGRARVWRM-DPEMMSLVTIVGSMNLAIGYQCEYIFQQKDIIDRLRNE-----HFDLAITESLFA 151

  Fly   153 EGALILGHLYQIPTITISTFGNANHLSQLF--------GVVSPWSYVPHAYMPYTDRMTLWERIG 209
            ....:..|      |.|....||.  |.||        |..:..||.|..:.|:.|:|:...|:.
Worm   152 CPFALFDH------IGIKNVINAE--SNLFKDAVKYAHGEPAAISYYPGLFSPHDDKMSFVARVK 208

  Fly   210 NVAMSAAEDLVREFSY---YPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPM 271
            |:...    |..::.|   |..:..::|.::    :...|.::|...::..|:||...:....|.
Worm   209 NMITM----LFTKYLYGSRYEKELEMIKPYY----NGTETWEDLFTGVAFNLINSNQYIDYPSPA 265

  Fly   272 AYNMIPVGGLHIQPPKA---LPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSL 333
            ....:.|||:.:...:|   |.:.....|:..... :..|.||...|:::|.|..|.||.|||::
Worm   266 LPKTVFVGGMQVNTNEAKTKLSDEWNNILNIRKQN-VLISFGSNAFSSEMPEEFKKSFLYVFGNM 329

  Fly   334 KQ-RVLWKFEDES---LPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILG 394
            .: ..:||:|:.:   ..:|| |||:.:|:||.|:||...:.:|:.||||..|.|..|.|.|.|.
Worm   330 PEITFIWKYEEANATLTSHLP-NVKLTTWMPQNDLLADDRLTLFVTHGGLGSTMELAYQGKPALI 393

  Fly   395 MPVYCDQHQNINQGKSAEYALGLDYRKVTV---EELRGLLMELIENPKYRNNIKKASRIFRDRPL 456
            :|:..||.:|.:..|  .:...|.|.|..:   |:|......::...||..|.::.:||.||:|:
Worm   394 IPLMADQPRNAHMLK--RHGGCLQYHKTMLGDSEQLLKAFKTVLTERKYSENAQRLARILRDQPV 456

  Fly   457 GAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILI 513
            ...|..:....:.:||.....|.:.|.:|..:|||..||..   ::::|.::||:.|
Worm   457 SPKDLVLKHCEFAVEHGALNSLNSRGRYLNTFQFYSFDIAS---SIVMLALLVLVFI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	135/510 (26%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	135/510 (26%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	136/512 (27%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	77/258 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161618
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790