DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-5

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_506200.1	Gene:	ugt-5 / 179753	WormBaseID:	WBGene00013906	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	121/569 - (21%)
Similarity:	218/569 - (38%)	Gaps:	94/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPF--SLAKEKL 70
            |:||:.::...:........:::..:  |.||......|..:|...||:||:..||  .|.|:..
Worm     5 HVFLIFVLLFIKNVASYNFLVISPVY--GFSHMKSMAIIANQLADAGHQVTYFQPFVVELFKDHD 67

  Fly    71 GSNYKEIVIPQY-----------------DFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIH 118
            ......|.|..|                 |.|...|..::....:....:...:|..|...|
Worm    68 LIKNPNIEIMNYFHDEEGKKNIPGHSVLSDAWTSYKYQSDVGQKIFAPRILHQSFQEMCRHM--- 129

  Fly   119 TTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG 183
                 .|...:...:.:|    |:|::|:|.|...|..:..:|.....|::.|....|.::...|
Worm   130 -----FEDEALHRQLKDK----KFDVVLSETFDFCGLYLADYLEMPAIISVFTGNRLNAITNALG 185

  Fly   184 VVSPWSYVPHAYMPYTDRMTLWERIGNV---AMSAAEDLVREFSYYPGQDAVLKKHFSKLLDR-- 243
            ..|...|:|.....:...|:|::|..|.   .:|::.                   |.:|.||
Worm   186 EPSFLHYLPSPSSSFNANMSLYDRFNNFWHKILSSST-------------------FGELFDRQY 231

  Fly   244 ----------VPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLD 298
                      ....|::..:::....||...|....|....:||:||..:...:..|  :.|.||
Worm   232 ADVYRLTNGKARHWKQILNDVTYHFSNSNPYLDFVIPTIAKVIPIGGYTMDYKQVPP--VSKDLD 294

  Fly   299 ---GATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDES----LPNLPANVKV 355
               ......::.|.|:.:.:..:|.|..:..::.|...|. ..|||:|:..    ..|:|.||.:
Worm   295 TILNLRSSTVFISYGTMISAKYMPDEYKQSMIDFFKDNKNVTFLWKYEEPEEKFIKENIPDNVHL 359

  Fly   356 QSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQN---INQGKSAEYALGL 417
            .:|.||..:||...||:||.||||..|.|..|:..|.:..|::.||..|   :.:..|.|.....
Worm   360 STWFPQQSLLADKRVKLFITHGGLGSTMELAYSAKPAIVTPLFADQPSNAQMLERHGSVEVLSKH 424

  Fly   418 D---YRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLV 479
            |   ::|.:     .||..::.:.||:....:.:.|..::|:...:..:............|.|.
Worm   425 DIPNWKKQS-----DLLKTMLADKKYQEAATRLADILNNQPISPRELMLKHAENAARFGKIPSLT 484

  Fly   480 AAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILI------CRRSSKPKS 522
            .....:.:.:||.:|::...::..|..|.|.|.|      |.::.|.|:
Worm   485 PFAKDMGFIEFYNIDLIIYSVSFTLFAIYVTIEIFGIVKNCCKTRKLKN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	117/552 (21%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	114/530 (22%)
ugt-5	NP_506200.1	egt	6..509	CDD:223071	112/542 (21%)
ugt-5	NP_506200.1	UDPGT	32..527	CDD:278624	115/532 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740