DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	149/573 - (26%)
Similarity:	233/573 - (40%)	Gaps:	96/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVT-FITPFSLAKEKL 70
            ::.||..|::|..::.|   :||.......:||.:....|...||..||:|. |||.:....|..
Worm     1 MYTFLFLLLSLLAVDAG---KILVYSPSISRSHLISNGRIADALVDAGHDVVMFITEYEPLTEFT 62

  Fly    71 GSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTF-------AFLRMVNVMGIHT---TDFALE 125
            |:. |..||....|..:..|        :|..:..:       :||..:......|   .|....
Worm    63 GTK-KAKVITMKGFSTKFAE--------DMDGIGEYLLSSSRLSFLERLMFEKTCTGACDDLMTR 118

  Fly   126 QPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSY 190
            :.|:     |:.:...:|:..:||....|..|:.:|.....:.|||....:.:|...|:.:|.||
Worm   119 REEL-----EQLRAYNFDVAFSEQIDLCGVGIVRYLGIKNHLWISTTPIMDAVSYNLGIPAPSSY 178

  Fly   191 VPHAYMPYT-------DRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIK 248
            ||      |       |:|..|:|..|:.|.....|:..:    |.|...:. |.|.:...|.::
Worm   179 VP------TIEENDNGDKMDFWQRTFNLYMKIGSILIHRY----GTDGTTEV-FRKYIPDFPNVR 232

  Fly   249 ELERNISAILLNSYMPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGATHGAIYFSLGSQ 312
            |:..|.|...:||...|...||.....|.||||.| :..|.|.:.....:.....|.:..||||.
Worm   233 EIAANSSLCFVNSDEVLDLPRPTITKAIYVGGLGIPKVSKPLDKKFTNIMSKGKEGVVIISLGSI 297

  Fly   313 VRSADLPPEKLKVFLEVFGSLKQRVLWKFED-----------------ESLPNLPANVKVQSWLP 360
            :...|||           .:.|:.||...::                 :.|.....||.|..|||
Worm   298 IPFGDLP-----------AAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGIKNVDVAEWLP 351

  Fly   361 QGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAE------YALGLDY 419
            |.|||:||.:|:|:.|||:.|..|.....||.:.:||:.||.:|   |:..|      ..|.||
Worm   352 QVDILSHPRLKLFVMHGGINGLVETAIQAVPTVIVPVFADQFRN---GRMVEKRGIGKVLLKLD- 412

  Fly   420 RKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVH 484
              :..|..:..::.::..|.|:.|..:..::.||:|....:....|..:.|:|.....|...|..
Worm   413 --IGYESFKNTVLTVLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSR 475

  Fly   485 LPWYQFYLLDIVGLGLAVILLPIVVLI-----LICRRSSKPKSTPTKKKTKKN 532
            |....:|.||::...|.|.:..:.|.|     |.|    |.:|....||:|||
Worm   476 LNTIIYYNLDVIAFVLFVFVAVLHVFIYAFKFLCC----KKRSQSNIKKSKKN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	140/552 (25%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	134/523 (26%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	142/554 (26%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	88/329 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710