DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-17

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001122841.1	Gene:	ugt-17 / 179406	WormBaseID:	WBGene00007422	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	151/565 - (26%)
Similarity:	246/565 - (43%)	Gaps:	77/565 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFP--GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK-- 69
            ||:|..:    ::.....::|.  |.|  |.||......|...|:..||:||.:.|.::..:|
Worm     8 IFILFSI----IDYSNSYKVLV--FNPAFGASHSNFLGKISDILIDAGHDVTMLIPIAMQGKKHL 66

  Fly    70 LGS-NYKEIV-IPQYDFWPEIKEMTNKNTVLEM------TDLPTFAFLRMVNVMGIHTTDFALEQ 126
            :|| ..|.|: |.|.....|:.:.|....||..      :|:.  .|.:|..... .|..:..:.
Worm    67 VGSKKVKNIIRIDQDPRSIELYKQTGAEDVLRKKIWKVESDIA--LFFKMAGNFS-KTCGYQCQH 128

  Fly   127 PEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLF--------G 183
            ...|..|.||.|...::|.:.|..|..|..:..||      .:.|..||:  |.||        |
Worm   129 VFQQTEILEKLKNEHFELGITESLFICGYPLFDHL------GVKTIINAD--SVLFMDIVKCTLG 185

  Fly   184 VVSPWSYVPHAYMPYTDRMTLWERIGNV----------AMSAAEDLVREFSYYPGQDAVLKKHFS 238
            ..|..::.|....|.||:|||.|||.|.          .|...|:|.....||.|         |
Worm   186 EPSSSTFYPALISPMTDKMTLVERIKNAIQMLIPVYFSKMRFEEELSMIEPYYNG---------S 241

  Fly   239 KLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATH- 302
            |      |.:||..|::..::||...|..:.|.....:.:||:.::..|.....|.|..|...:
Worm   242 K------TWEELLENVAFNMVNSNRYLDYASPTLPKTVFIGGMQVKTKKQGTPKLNKEWDDLLNI 300

  Fly   303 --GAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDE--SLPNLPANVKVQSWLPQG 362
              ..:..|.||...|:::|.|..|.||:||.|:.: ..:||:|.|  ::....:|||:.:|:||.
Worm   301 RKENVLVSFGSNAFSSEMPDEFKKSFLDVFASMPEITFIWKYEQENSTIAMHLSNVKMTTWMPQS 365

  Fly   363 DILAHPNVKVFIAHGGLFGTQEAVYNGVP----ILGMPVYCDQHQNINQGKSAEYALGLDYRKVT 423
            |:||...:.:|:.||||..:.|..|.|.|    |..:|:..||.:|.:.......|:.||  |..
Worm   366 DLLADNRLSLFVTHGGLGSSIELAYQGTPAVVNIFKIPLMADQPRNAHMLTRHGGAIQLD--KTN 428

  Fly   424 VEE---LRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHL 485
            ::.   :|..:..:::|..|..|.:|.::|..|:|....:..:...::.::......|.:.|..|
Worm   429 LDNPQMIRDAIKTILDNDSYTENARKLAQILEDQPYTPAEVVLKHCDFAVKFGVLDTLQSEGRKL 493

  Fly   486 PWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTK 530
            ..:|||..||:.:...:|:..:|.::|...:..|..||...||.|
Worm   494 NVFQFYSYDILVVVCFLIITVVVFIVLYVFQCIKICSTIFSKKVK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	144/546 (26%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	138/517 (27%)
ugt-17	NP_001122841.1	egt	1..513	CDD:223071	143/538 (27%)
ugt-17	NP_001122841.1	UDPGT	22..538	CDD:278624	147/545 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161615
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790