DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-9

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504312.1	Gene:	ugt-9 / 178883	WormBaseID:	WBGene00020587	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	136/554 - (24%)
Similarity:	229/554 - (41%)	Gaps:	84/554 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYK 75
            |||::.:  :.|.:...||......|.||....:.:...:...||.||...||.:|.:......|
Worm     6 LLSILLV--ISLVSCKNILVYNPIFGYSHAKFVSQLANIIADHGHNVTVFQPFHIALKNTDGLIK 68

  Fly    76 EIVIPQYDFWPE-IKEMTNKNTVLEMTDLPTF---------------AFLRMVNVMGIHTTDFAL 124
            ...|...:::|: ..|:..|.|       |||               :|| |...:|........
Worm    69 NKNIEIINYYPDHYAELLKKKT-------PTFPDFWDSHLMNNPVLSSFL-MPKALGGEFEQTTT 125

  Fly   125 EQPEIQAVINE-KNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPW 188
            :..:.|.::|: ||:  .:|:||||.|...| ..:..|.:||:|.:.:......:...||..|..
Worm   126 QLFQDQKILNDLKNR--NFDVLLAETFEIAG-FYIADLLEIPSIPLMSAVRLPIIDSAFGQPSIL 187

  Fly   189 SYVPHAYMP------YTDRMT------LWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLL 241
            .|.|..|..      :.||:.      .|............|.:::...:|
Worm   188 GYFPQQYSKVAPEAGFLDRLNDLYRIFFWNLTTQRLCQFQNDFIQKAIGHP-------------- 238

  Fly   242 DRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPK-----ALPEHLQKFLDGAT 301
              ||..::|.:.....:.||...|..:.|....::.|||:.|...|     ||.|..:..| ...
Worm   239 --VPHWRDLVKESPIYITNSNSYLDFAVPTTATIVHVGGITIDLEKMRHVAALTEEYENIL-AER 300

  Fly   302 HGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDESLP---NLPANVKVQSWLPQG 362
            ...::.|.||.:||.::|.......:::|.||.. ..:||:|.:.:.   .||.||.::.|:||.
Worm   301 ESTVFISFGSVIRSYEMPDNFKAGIIKMFKSLPDVTFIWKYEKDDVKFQNRLPKNVHLKKWVPQP 365

  Fly   363 DILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTV--- 424
            .:||...||:|:.||||..|.|..|.|.|.|.:|::.||..|.:.  .|.:...:.|.|..:
Worm   366 SLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPNNADM--LARHGGAVAYDKFDLADG 428

  Fly   425 EELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIE---HRG-APHLVAAGVHL 485
            |:|...:.:::.|.||..|.::..::...:|:......:..:.:.:|   ||. .|.:...|:
Worm   429 EKLTKTVRDMVTNSKYEVNAQELLKVLSKQPIDPKLNLMKHLEFAMEFPKHRSQVPAINRTGL-- 491

  Fly   486 PWYQFYLLDIVG-LGLAVI--LLPIVVLILICRR 516
              ...|.||::| |.||.|  |..|..::.|.|:
Worm   492 --IAHYYLDVIGVLTLASIFGLFVIFKILNILRK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	134/549 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	128/524 (24%)
ugt-9	NP_504312.1	egt	20..462	CDD:223071	115/471 (24%)
ugt-9	NP_504312.1	UDPGT	30..532	CDD:278624	129/528 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740