DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	146/575 - (25%)
Similarity:	234/575 - (40%)	Gaps:	116/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELGTGSRILAAFFFP--GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGS--NYKEIVIP 80
            |::...::||  .|.|  |.||....:.:...:...|.|||...||.||.:.|..  ..|.|.|.
Worm    13 LKVNYAAKIL--IFNPIFGFSHVKFVSKLADIIADHGQEVTLFQPFHLALKNLDGIVKNKNIEII 75

  Fly    81 QY-----------------DFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPE 128
            .|                 |||.  .::.| |.||....||     |::......||...::..|
Worm    76 NYYPDHYDDLLKLETQTFPDFWD--SQLMN-NPVLMAFMLP-----RILGGEFKKTTIQLIKDKE 132

  Fly   129 IQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYV-- 191
            |...:.:|    |:|:.::|.|...| :.:.|...:|.|.|.:....:..::.||..|.:.|:
Worm   133 ILKKLKDK----KFDVAISETFELTG-MYMSHFLGVPCIPILSAVRLDIFNEAFGQSSAFGYLTQ 192

  Fly   192 ------PHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDR------- 243
                  |.|  .:.||:              .|:.|:|             |||:..|
Worm   193 QGSKLAPDA--GFLDRL--------------NDVYRDF-------------FSKMAFRGMAQYQN 228

  Fly   244 ----------VPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPK-----ALPEHL 293
                      ||..|:|.:.....:.||...|..:.|....::.:||:.|...|     ||||..
Worm   229 DVIEKAAGHVVPYWKDLVKEAPVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVDALPEEY 293

  Fly   294 QKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRV-LWKFEDESL---PNLPANVK 354
            :..|. .....:..|.||.:||.::|.......::||.||...: :||:|.:.|   ..||.||.
Worm   294 EIILK-EKETTVLISFGSVIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVH 357

  Fly   355 VQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDY 419
            ::.|:||..:||...||:|:.||||..|.|..|.|.|.|.:|::.||..|.:.  .|.:...:.|
Worm   358 LKKWVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADM--LARHGGAIAY 420

  Fly   420 RK---VTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIE----HRGAPH 477
            .|   |..::|...:.:|:.||||....|:...:..::|:..:...:..:.:.|:    ....|.
Worm   421 DKFDLVDGKKLTETVRDLVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPNLRSQIPE 485

  Fly   478 LVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            :...|   |...:||..||.|....|:...:...::||..|:..|    ||.|.:
Worm   486 INQVG---PIAHYYLDVIVFLIFVSIITAYISFQIVCRILSRILS----KKVKSD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	139/554 (25%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	133/536 (25%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	80/299 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740