DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-12

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_504309.1	Gene:	ugt-12 / 178880	WormBaseID:	WBGene00020592	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	144/563 - (25%)
Similarity:	236/563 - (41%)	Gaps:	79/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELGTGSRILAAFFFP-------------GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLG 71
            :.|||...:|...||.             |.||....:.:...:...||.||...|:.:|.:.|.
Worm     1 MRLGTFIFLLTFLFFECYSSKILIFNPIFGFSHVKFISKMADIIADHGHHVTLFQPYHIALKNLD 65

  Fly    72 SNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAF--------------LRMVNVMGIHTTDF 122
            ...|...|...::.|     |:...:|: .:..||:|              ..|..::|......
Worm    66 GLVKNKNIEILNYHP-----THYEELLK-AEPQTFSFFWDSYLVGNPVIGAFLMPKLLGGEFKKT 124

  Fly   123 ALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSP 187
            |:|....|.:|||. |..|:||::||.|...| ..|.||..:|.|.:.:.......:..||..|.
Worm   125 AMEVLSDQKLINEL-KDRKFDLVIAETFELTG-FYLAHLLDVPCIPMMSAVRYPIFNDQFGQPSL 187

  Fly   188 WSYVPHAYMPYTDRMTLWERIGNV----AMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIK 248
            ..:||............::|:.::    .|..:::.:.::..|..::|:.:.        ||..|
Worm   188 LGHVPQIGSAVAGEAGFYDRLNDMFRFFFMGISQEQLNKYQNYFIEEAIGRP--------VPFWK 244

  Fly   249 ELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPK-----ALPEHLQKFLDGATHGAIYFS 308
            :|.:.....:.||...|..:.|....::.|||:.:...|     .|||..:..|. .....:..|
Worm   245 DLVKQSPIYITNSNPYLDYAVPSTAAIVQVGGITMDLKKLKQVGELPEEYENILK-ERESTVLIS 308

  Fly   309 LGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFEDESL---PNLPANVKVQSWLPQGDILAHPN 369
            .||.:||.::|.......::||.||.. ..:||:|.:.|   ..||.||.::.|:||..:||...
Worm   309 FGSVIRSYEMPESFKAGLIKVFESLPDVTFIWKYEKDDLEFQKRLPKNVHLKKWIPQPSLLADKR 373

  Fly   370 VKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTV---EELRGLL 431
            ||:||.||||..|.|..|.|.|.:.:|::.|||.|...  .|.:...:.|.|..:   |:|..::
Worm   374 VKLFITHGGLGSTMEVAYTGKPAIVVPIFGDQHHNAVM--LARHGGAVAYDKFDLKNGEKLTAVV 436

  Fly   432 MELIENPKYRNNIKKASRIFRDRP-------LGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQ 489
            .|:|.:.||:.|.:....:..::|       |..:|.||.:.|    ||..   |.|...|.:..
Worm   437 HEMISSTKYQENAEALQHVLFNQPIDPKMNFLNHLDFAIKFPN----HRAQ---VPAINQLGFVA 494

  Fly   490 FYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            .|.||::   |.:::..||:..|......|.......||||.:
Worm   495 HYYLDVL---LFLLVSSIVITYLAISLLKKVLGKCLTKKTKSD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	138/542 (25%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	132/513 (26%)
ugt-12	NP_504309.1	MGT	28..453	CDD:273616	115/443 (26%)
ugt-12	NP_504309.1	egt	<132..514	CDD:223071	110/404 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740