DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt-29

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001370778.1	Gene:	ugt-29 / 178581	WormBaseID:	WBGene00021709	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	131/542 - (24%)
Similarity:	228/542 - (42%)	Gaps:	68/542 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPF---SLAKEKL 70
            ||.|...:...|.:...|...||      ||......:...|.::||.||::.|.   ....|.:
Worm     7 IFTLLFCSSSSLNILVYSPAYAA------SHSNFLGKLADTLTERGHNVTYLMPVMDPGKRDECI 65

  Fly    71 GSNY-KEIVIPQYD-----------FWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFA 123
            |... |::||.:.|           ...||.|:..|:.:........|:|..  |.|.....:|
Worm    66 GVKLTKDLVIVEADEEMMSREEGVTLDEEIMELYWKSEMDSSNSRDMFSFFN--NAMKAACRNF- 127

  Fly   124 LEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPW 188
            |::.:|...:..:|    :|:.:.|.....|...:..|....||..|:....:.:....|....:
Worm   128 LKRRDIFEQMKSRN----FDVAIVEPLSVCGLGFVKALGIEKTILASSCTFYDSIMDYIGEPLDF 188

  Fly   189 SYVPHAYMPYTDRMTLWERIGNVAMSAA---------EDLVREFSYYPGQDAVLKKHFSKLLDRV 244
            ||||..:....|.||:.||..|..::..         :|.::.:..:.|||             :
Worm   189 SYVPALFSVTGDVMTMSERYENWMVTKEINIGIHEKFDDEMKSYREFLGQD-------------L 240

  Fly   245 PTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQ----PPKALPEHLQKFLDGATHGAI 305
            |..:||....|...:||.......||:....:|:||:.:.    ..:.|.:..::.|: .....:
Worm   241 PDWRELLSTASIFFINSNPFFDFPRPVLQKTVPIGGISVNLKWIKEQKLTKDWEEVLE-MRKKTV 304

  Fly   306 YFSLGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFE--DESLPNLPANVKVQSWLPQGDILAH 367
            ..|.||.|:||.:|.:.....|:|..|:.. ..:||:|  |.|..:..:|:....|:||..:|..
Worm   305 LISFGSLVKSAYMPKKWRNGLLDVIKSMPDVTFIWKYETDDVSFADGVSNIHFSKWVPQTALLND 369

  Fly   368 PNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNIN-----QGKSAEYALGLDYRKVTVEEL 427
            |.:.||:.||||..|.|..|:|.|.:.:||:.||.:|.|     :|....:...::..|||
Worm   370 PRLSVFVTHGGLGSTMELAYSGKPAVVIPVFADQIRNANMIARHRGVIYLHKNSMENVKVT---- 430

  Fly   428 RGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYL 492
            |....:::.:..|:.|.:|.:.|..::|....:..|.:..::.||...|::...|.||.::|...
Worm   431 RKAFTDVLFDDSYQKNAEKLANILMNQPYSPKENVIKYTEFLGEHGPFPNMDPHGRHLNYFQKTF 495

  Fly   493 LDIVGL-GLAVILLPIVVLILI 513
            |||..| .|..|.:..::::.|
Worm   496 LDIYTLFALFYIFVSTIIIVTI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	130/540 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	124/513 (24%)
ugt-29	NP_001370778.1	GT1_Gtf-like	18..468	CDD:340817	114/480 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790