DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	123/540 - (22%)
Similarity:	230/540 - (42%)	Gaps:	66/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN 73
            :|||..|    |...:..:||.:....|.||......:...||:.||:|||:.|..:...:.|:.
Worm     5 VFLLLFV----LPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQNGTE 65

  Fly    74 Y-KEIVIPQYDFWPEI---------------KEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDF 122
            . |.:::|..|...||               ....:|..::..||        |:..:..|.|..
Worm    66 LAKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTD--------MIGQVSYHNTKN 122

  Fly   123 ALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGAL---ILGHLYQIPTITISTFGNANHLSQLFGV 184
            .::.   :|:: ::.|..|:|:.:.|.|...|..   ::|....:...|.|.|...     |...
Worm   123 LIDN---KALV-QQMKDEKFDIGITELFDFSGLAFFEVIGLKNVMGAHTTSVFEGT-----LMAT 178

  Fly   185 VSPW--SYVPHAYMPYTDRMTLWERIGNVAMS----AAEDLVREFSYYPGQDAVLKKHFSKLLDR 243
            .:|.  |:||.:.....|..::..|:.|:.|:    ..::.::.|:     ...|.:|:.|  .:
Worm   179 GAPILPSFVPASQTFTDDSGSILSRLNNLYMTYWSYQFQNKIQSFA-----QKALDEHYEK--GK 236

  Fly   244 VPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFS 308
            .|.|..|..:|:...:||.......:|:..|::.:.|:.:...|.:.:...:.|...:.. :..|
Worm   237 APKIWNLVSDITWFFVNSDPIFDFPKPLPQNIVEIAGISVPEIKPVGKEWDEILSKRSKN-VLVS 300

  Fly   309 LGSQVRSADLPPEKLKVFLEVFGSLKQ-RVLWKFED-ESLPNLPA---NVKVQSWLPQGDILAHP 368
            .||......:|....|..::.|.:... ..:||::| ||  .|.|   ||.:..|:||.|:||..
Worm   301 FGSIASPTTMPEAVKKSIVDAFAAFPDVTFIWKYDDTES--KLTAHLDNVHIVKWMPQNDLLADK 363

  Fly   369 NVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKV---TVEELRGL 430
            .:.:|..|||:....|:....||::.:|::.||.:|....|  .:.:.|.|.|:   ..::|.|.
Worm   364 RISMFWTHGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAK--RHGVALIYDKMDLSNTKKLIGA 426

  Fly   431 LMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDI 495
            |.|::|||:|:.:.:..:||............|..:.........|...:||....:.:::.||:
Worm   427 LKEVLENPEYKKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDL 491

  Fly   496 VGLGLAVILLPIVVLILICR 515
            |.:.:.:..|.||..:|:.|
Worm   492 VIIAVFIFFLSIVSTVLLIR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	121/536 (23%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	114/509 (22%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	118/527 (22%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	117/519 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860