DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-60

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001021158.1	Gene:	ugt-60 / 176366	WormBaseID:	WBGene00007402	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	133/564 - (23%)
Similarity:	223/564 - (39%)	Gaps:	116/564 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPG--KSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK 69
            |.||.:.|..:..|      |||.  ..||  .||.:....:...|...||:|...|...:|...
Worm     3 LPIFCIFLSVVDSL------RILQ--IVPGFTNSHVLFNYRLAETLRFLGHDVKMWTQMEMAMLD 59

  Fly    70 LGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVM-------------GIHTTD 121
            .|:|.....:.:|            ...:..||......|::...|             |....|
Worm    60 TGNNKLPEGVSEY------------RIPIHFTDTLKTEGLKVFQSMMFESGDAHDLWWTGQEFKD 112

  Fly   122 FALEQPEIQAVINEKNKIGKYDLLLAEQFFNEG-ALILGHLYQIPTITISTFGNA------NHLS 179
            ..:|..|         ::.::|..:.|.|..:| .:.:.|.:.:..:.|:...|.      .|.:
Worm   113 MRVEACE---------QMLRHDESVYEDFRKDGFDVAIAHFHDLCPLAIAKKMNVKRVIWITHGT 168

  Fly   180 QLF-------GVVSPWSYVPHAYMP------YTDRM--TLWE----RIGNVAMSAAED---LVRE 222
            .::       |:.:..|.:||....      :.||:  |||.    ...|:..:...|   ..||
Worm   169 SIYEFSAVQLGLRTIPSTIPHPLSSAGFSQLFLDRVQNTLWHLSLLDFVNLPQNLLVDENLFYRE 233

  Fly   223 FSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPK 287
            |   .|.|.      ..|.|...|      .:.::|:|....|...||:..::...|.|.:...|
Worm   234 F---VGADQ------DDLWDLAKT------TVPSLLINGDRMLDFPRPLPIHIAFSGELGVSKGK 283

  Fly   288 AL--PEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLK-QRVLWKFEDESLPNL 349
            .|  .:.|:..::..:.|.|.||||:...:.::|.:.:..||..||.|| ..:||:.| :|:...
Worm   284 KLVMEKWLEDIIEKPSDGLIVFSLGTVSNTTNMPAQMINSFLGAFGKLKTYTILWRME-KSVAGA 347

  Fly   350 P--ANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAE 412
            .  .|:.:..||||.||:.||.:|:.|||||.....||...|:|.:.||::.||..|..:.:...
Worm   348 EKYENLHLVKWLPQKDIMRHPKMKLMIAHGGYNSFLEAAQAGIPAVLMPLFADQKINAKRAQRYG 412

  Fly   413 YALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRD----RPLGAMDTAIYWINYVIEHR 473
            .|..||...:|:..:.|.:.|.:: |:|..|.||.|.:..|    :|..|       :.|.::..
Worm   413 MATVLDKLDLTINNVYGAIKEALK-PEYSTNAKKLSAMLSDQVARKPYSA-------LRYSLKLA 469

  Fly   474 GAPH---LVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILIC 514
            .:|.   ......||.:.:|:.|||    .:::||   ...::|
Worm   470 TSPKPSLFTLKSQHLSFLEFHNLDI----FSIVLL---TAFIVC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	132/561 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	123/531 (23%)
ugt-60	NP_001021158.1	Glycosyltransferase_GTB_type	17..>161	CDD:299143	31/166 (19%)
ugt-60	NP_001021158.1	egt	<253..464	CDD:223071	66/219 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910