DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	130/540 - (24%)
Similarity:	226/540 - (41%)	Gaps:	79/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GKSHFMMTNAIIR---ELVKQGHEVTFITPFS--LAKEKLG-SNYKEIVIPQYD----------- 83
            |.||   ||.:.|   .|.:.||.|||:.|.:  ..|.:|| ...|::||.:.|
Worm    28 GGSH---TNFMARLADTLTEAGHNVTFVVPVADEARKGQLGVKKTKDVVIVEQDELMKSEIKPLD 89

  Fly    84 -----FWPEIKEMTNKNTVLEMTD----LPTFAFLR---MVNVMGIHTTDFALEQPEIQAVINEK 136
                 :|....:.:|.:::..:..    |....|:|   :.|.:.....|..:.:|.....:...
Worm    90 DDMAQYWETDMDSSNADSIFSVFSDAMLLSCNNFMRNKKVFNELKSRNFDVGIYEPLSVCGLGYM 154

  Fly   137 NKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDR 201
            :.||...|:::    :..||..|        |::..|..          ..:||||.:.....::
Worm   155 HAIGINKLIMS----SSCALYDG--------TVAAIGEP----------IDFSYVPGSMSKSGEK 197

  Fly   202 MTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLA 266
            |:|:|::.|..:|.|...: ::..:..:..:.|||   |.:.:|..::|..:.|....||...:.
Worm   198 MSLFEKLENYRLSMASSRM-QYGQWDKETEIYKKH---LGNDIPHWRDLMPSSSVAFTNSIPYVD 258

  Fly   267 SSRPMAYNMIPVGGLHIQPPKALPEHL----QKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFL 327
            ..|.:....:|:||:.:.......:.|    ...||...|..: .|.||.|||.|:|.:.....|
Worm   259 FPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHNML-ISFGSMVRSMDMPLKWRNGLL 322

  Fly   328 EVFGSLKQ-RVLWKFEDESLPNLPA--NVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNG 389
            |...|... ..:||:|:::|.....  |:....|:||..:|....:..|:.||||..|.|..:.|
Worm   323 EAIKSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALLNDARLTAFMTHGGLGSTNELAFLG 387

  Fly   390 VPILGMPVYCDQHQNINQ-----GKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASR 449
            .|.|.:||:.||.:|.|.     |....:...|...|.....:|.:|.|    .||:.|.:|.|.
Worm   388 KPALMVPVFADQDRNANMLARHGGVLVVHKKELGNFKTIKSSIRSILHE----EKYQKNARKLSE 448

  Fly   450 IFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILIC 514
            :..::||...:..:.:..:|.:....|.:.:.|..|.:.|..|:||.. .:::..|.::.||...
Worm   449 LLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFIQRNLIDIYA-AISLSYLFVISLIYFV 512

  Fly   515 RRSSKPKSTPTK--KKTKKN 532
            .:....| ||.|  |..||:
Worm   513 FKFVISK-TPLKLVKLVKKD 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	123/517 (24%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	122/517 (24%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	114/482 (24%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	127/536 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860