Protein Alignment Ugt49B1 and UGT3A2

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 162/575 - (28%)
• Similarity: 261/575 - (45%)
• Gaps: 103/575 - (17%)

  Fly    25 GSRI--LAAFFFP----------------GKSHFMMTNAIIRELVKQGHEVTFIT----PF---- 63
            |.|:  |..|..|                |.||:::.:.:.:.|...||.||.:.    ||
Human     3 GQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPGL 67

  Fly    64 --SLAKEKLGSNYKEIV-IPQY------DF-----------W--PEIKEMTNKNT---VLEMTDL 103
              |.|.   .|.|..|: :.:|      ||           |  ||..:...|.:   .||.|..
Human    68 SDSPAS---ASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLG 129

  Fly   104 PTFAFLRMVNV---MGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIP 165
            ....|..::||   :.:..:.| |.:.:|...:..:|    :|:::.|.|.....||...|.: |
Human   130 GRGKFENLLNVLEYLALQCSHF-LNRKDIMDSLKNEN----FDMVIVETFDYCPFLIAEKLGK-P 188

  Fly   166 TITI--STFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPG 228
            .:.|  ::||:..     ||:..|.||||......||.|..|.|:.|..|.        ||:...
Human   189 FVAILSTSFGSLE-----FGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLMF--------FSFCRR 240

  Fly   229 Q-------DAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPP 286
            |       |..:|:||::  ...|.:..|........:||......:||:..|.:.||||..:|.
Human   241 QQHMQSTFDNTIKEHFTE--GSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPI 303

  Fly   287 KALPEHLQKFL-DGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLP--- 347
            |.:|:.|:.|: .....|.:..:|||.|.:.. .||..|.....|..|.|.|:||.:....|
Human   304 KPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQ-NPEIFKEMNNAFAHLPQGVIWKCQCSHWPKDV 367

  Fly   348 NLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAE 412
            :|.||||:..||||.|:||||::::|:.|||.....||:.:|||::|:|::.||.:|:.:.::.:
Human   368 HLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAKK 432

  Fly   413 YALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPH 477
            :.:.:..:|:..|.|...:.:::|:.:|::....||.|.|..||......:.||::|::..||.|
Human   433 FGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGATH 497

  Fly   478 LVAAGVHLPWYQFYLLDI----VGLGLAVI-----LLPIVVLILICRRSSKPKST 523
            |.......||::.||||:    :||.|..:     ||.:.|..|  |.:.|.|.|
Human   498 LKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAVWWL--RGARKVKET 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	157/563 (28%)
		UDPGT	38..515	CDD:278624	152/534 (28%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	146/519 (28%)
		egt	<162..517	CDD:223071	115/375 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740