DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	145/537 - (27%)
Similarity:	246/537 - (45%)	Gaps:	90/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEV--------------------TFITPFSLAKEKLGSNYKE------ 76
            ||::....|:..|.::||::                    :|..|::|  |:|.:.|:.
  Rat    36 SHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNL--EELRTRYRSFGNNHF 98

  Fly    77 -----IVIPQYDFWPEIKEMTNKNTVLEM---------TDLPTFAFLRMVNVMGIHTTDFALEQP 127
                 ::.|       ::|..|...|::|         .|..|.:|||.
  Rat    99 AASSPLMAP-------LREYRNNMIVIDMCFFSCQSLLKDSATLSFLRE---------------- 140

  Fly   128 EIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG-VVSPWSYV 191
                        .::|.|..:.....| :||....::|::.:.. |....|..:.| ..||.|||
  Rat   141 ------------NQFDALFTDPAMPCG-VILAEYLKLPSVYLFR-GFPCSLEHMLGQSPSPVSYV 191

  Fly   192 PHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISA 256
            |..|..::|.||..:|:.|...:..|:.:....|  .:..:|.   |.||.|..::..|.:| |.
  Rat   192 PRFYTKFSDHMTFPQRLANFIANILENYLYHCLY--SKYEILA---SDLLKRDVSLPALHQN-SL 250

  Fly   257 ILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPP 320
            .||.........||:..|||.:||.:.:....|.:..:.:::.: .||.:.|||||.|  :::|.
  Rat   251 WLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPE 313

  Fly   321 EKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEA 385
            :|.....|..|.:.|.|||::......||..|..:..||||.|:|.||..:.||.|.|..|..|.
  Rat   314 KKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEG 378

  Fly   386 VYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRI 450
            :.||||::.||::.||..|..:.::....:.|:..::|.::|...|..:|.|..|:.||.:.|.:
  Rat   379 ICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSL 443

  Fly   451 FRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICR 515
            .:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.||::|..||::|..:.::...|.
  Rat   444 HKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCA 508

  Fly   516 RSSKPKSTPTKKKTKKN 532
            ...: |....|.:.||:
  Rat   509 YGCR-KCFGGKGRVKKS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	140/516 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	140/518 (27%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	140/514 (27%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	143/532 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860