Protein Alignment Ugt49B1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 157/526 - (29%)
• Similarity: 256/526 - (48%)
• Gaps: 61/526 - (11%)

  Fly    38 SHFMMTNAIIRELVKQGHEVTF--------------------ITPFSLAKEKLGSNYKEIVIPQY 82
            ||::....|:.||:::.|.||.                    :.|.|..|..:.|..:.:::...
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly    83 DFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVM-------GIHTTDFALEQPEIQAVINEKNKIG 140
            |..|              |.|..:||.:.:..:       .|...|..|:.|::.|.:.:    |
Human   306 DHRP--------------TPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQK----G 352

  Fly   141 KYDLLLAEQFFNEG---ALILGHLYQIPTITISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDR 201
            .:|:|:|:.....|   ||.||    ||.:....|..|:.:.:..| :.:|.||||.|....||:
Human   353 GFDVLVADPVTICGDLVALKLG----IPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQ 413

  Fly   202 MTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLA 266
            ||..|||.|....:.:|.:  |..|.|:   ...::||:|.|..|:.|........|:.:|....
Human   414 MTFGERIKNTISYSLQDYI--FQSYWGE---WNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFE 473

  Fly   267 SSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVF 330
            ..||...|...|||||.:|.|.||:.:::|:..: .:|.:.|||||.|:  :|..||..:.....
Human   474 FPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NLTEEKANLIASAL 536

  Fly   331 GSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGM 395
            ..:.|:|||:::.:....|..|.::..|:||.|:|.||..|.||.|||..|..||:|:|||::|:
Human   537 AQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGV 601

  Fly   396 PVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMD 460
            |::.||..||...|:...|:.::...:|..:|...|..:|..|.|:.|..:.|||..|:|:..:|
Human   602 PMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLD 666

  Fly   461 TAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPT 525
            .|::||.:|:.|:||.||..|...|.|:|::.||::|..|..:...|.::|..|..|.:......
Human   667 RAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIG 731

  Fly   526 KKKTKK 531
            |||.::
Human   732 KKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	152/508 (30%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	154/512 (30%)