DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	525	Identity:	157/525 - (29%)
Similarity:	254/525 - (48%)	Gaps:	59/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP--FSLAKEKLGSNYKEIVIPQYDFWPEIKEMTN-KNTVLE 99
            ||:|....|:.|||::|||||.:.|  :.:...|.....|      ::.:|......| :|..::
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLK------FETFPTSVSKDNLENFFIK 92

  Fly   100 MTDLPTFAFLRMVNVMGIHTTDFALE-QPEIQAVINE--------------------KNKIGKYD 143
            ..|:.|:...|          |..|. .|.:|.:|:|                    |.:..|:|
Mouse    93 FVDVWTYEMPR----------DTCLSYSPLLQNMIDEFSDYFLSLCKDVVSNKELMTKLQESKFD 147

  Fly   144 LLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMTLWER 207
            :||::...:.|.|| ..|.|||.:....|.....:.:..| .:.|.||||........:||..||
Mouse   148 VLLSDPVASCGELI-AELLQIPFLYSIRFSPGYQIEKSSGRFLLPPSYVPVILSGLGGQMTFIER 211

  Fly   208 IGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMA 272
            :.|:...    |..:|.:....|......:|:.|.|..|:.|........|:.|...|....|..
Mouse   212 VKNMICR----LYFDFWFQMFNDKKWDSFYSEYLGRPTTLAETMGKAEMWLIRSNWDLEFPHPTL 272

  Fly   273 YNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQR 336
            .|:..|||||.:|.|.||:.:::|:..: .||.:.|||||.|  :::..||..........:.|:
Mouse   273 PNVDYVGGLHCKPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANTIAWALAQIPQK 335

  Fly   337 VLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQ 401
            |||||:.::...|..|.:|..||||.|:|.||..|.|:.|||..|..|.:|:|:|::|:|::.:|
Mouse   336 VLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEVIYHGIPMIGIPLFGEQ 400

  Fly   402 HQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWI 466
            |.||....:...|:.|:.|.::..::...|.|:|:||.|:.|....|.|..|:|...:|.|::|:
Mouse   401 HDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFYKKNAIWLSTIHHDQPTKPLDRAVFWV 465

  Fly   467 NYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVV----LILICRRSSKPKSTPTKK 527
            .:|:.|:.|.||.:.|.:|.|:|::.||::|..|:.:.:.||:    |:.|.|...|      |:
Mouse   466 EFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAVTIVLTVKCLLFIYRFFVK------KE 524

  Fly   528 KTKKN 532
            |..||
Mouse   525 KKIKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/504 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	151/506 (30%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	147/494 (30%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	154/520 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840786
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690