DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt5f1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_017207383.1	Gene:	ugt5f1 / 100415800	ZFINID:	ZDB-GENE-100406-6	Length:	556	Species:	Danio rerio

Alignment Length:	555	Identity:	174/555 - (31%)
Similarity:	270/555 - (48%)	Gaps:	84/555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLLSLVALQ-QLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFI----------- 60
            ||::.:|.|. .|.:..| :||.   ||.: ||::..|.:|.||..:||:::.|
Zfish    35 IFVVQIVVLSLTLPVHCG-KILV---FPHEGSHWLNLNTLIEELHHRGHQISVIRALDSWYIPET 95

  Fly    61 --------TPFSLAKEKLGSN-------YKEIVIPQYDFWPEIK-EMTNKNTVLEMTDLPTFAFL 109
                    .||.|.    |.:       ::::.|.:...|...| :|..|....||.
Zfish    96 SPHYDSINVPFLLG----GDDQFYHSFIFRQLQIRREQRWTRFKLDMELKEKFSEMH-------- 148

  Fly   110 RMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIP---TITIST 171
            |.:..|.||..:   ::|.|...|.|.|    :|::|.:. .|.|.::|.|...:|   .:..:.
Zfish   149 RKICEMVIHIVE---KEPAIMKQIKEAN----FDIMLTDP-ANGGGVVLAHYLHLPLVFNVQWTV 205

  Fly   172 FGNANHLSQLFGVV-SPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKK 235
            .|.|:     |.:. ||.||||......||.|:..:||.||..||    ||.|.|    ...:..
Zfish   206 HGEAH-----FAIAPSPPSYVPFPLSQLTDSMSFPQRIYNVLFSA----VRLFLY----RRTVGP 257

  Fly   236 HFSKLLDRV--PTIK--ELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKF 296
            |:|.|.:|:  |.:.  ||.:.....|:.:.......||...|:|.:||.|..|.||||:.|:.|
Zfish   258 HYSALCNRLFGPGLDYFELFQAADIWLMRADFVFDFPRPTMPNVIYIGGFHCSPAKALPKDLEDF 322

  Fly   297 LDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLP 360
            |..: .||.|..|||:.|  |.||.:.....:..|..|.|:|:|::..:...|:..|..:.:|||
Zfish   323 LQSSGEHGVIVMSLGTLV--AQLPMDIADEIVAAFAELPQKVIWRYTGDRPANVGNNTLLVNWLP 385

  Fly   361 QGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVE 425
            |.|:|.||..:||::|||..|..||:|:||||:|:|:..||..|:.:.|....|..||...:...
Zfish   386 QNDLLGHPKTRVFVSHGGTNGVFEAIYHGVPIVGLPLVFDQDYNLLKMKHKGVAKVLDIATINRN 450

  Fly   426 ELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQF 490
            ..:..|.|::.:|.||:|::|.|.:.:|.||..:|:|::|..:|:.||||.||......:|||.:
Zfish   451 IFKDALQEVLNDPSYRSNMQKLSSLHKDTPLKPLDSALFWTEFVMRHRGAAHLRTDSYKMPWYSY 515

  Fly   491 YLLDIVGLGLAVILLPIVVLI------LICRRSSK 519
            :.:| ||:.|..:|..||.|:      |.||..:|
Zfish   516 HSVD-VGVFLVSVLCFIVFLMFKIVRCLCCRFCAK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	170/547 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	161/518 (31%)
ugt5f1	XP_017207383.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585206
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790