DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	524	Identity:	149/524 - (28%)
Similarity:	250/524 - (47%)	Gaps:	71/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFI-TPFSLAKEKLGSNYKEIVIPQ---YDFWPEIKEMTNKNTVL 98
            ||::..|.::..|..:||:||.: |..|...::...:|..|.:..   |:  .|:.|......:.
Zfish    37 SHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSPHYTSINLKSKGGYN--KEVLEQFASRIMH 99

  Fly    99 EMTDLPTFAFLRM-VNVMGIHTTDFALEQPEIQAVINEKN-----KIGKYDLLLAE-QFFNEGAL 156
            .:.|..|:..|:: .::.......|..|:..|..:|.::.     |..||||:|.: ..|  |.:
Zfish   100 ILRDGSTWGHLKLQADMWQSFLKIFEAEREMIVNMIEDQQLMQSLKDAKYDLILTDPNMF--GGV 162

  Fly   157 ILGHLYQIPTITISTFGNANHLSQLFGVV-SPWSYVPHAYMPYTDRMTLWERIGNVAM------- 213
            ||||..::|.:....:...|...  |.:. ||.||||...:..:|||:..:|:.||.|
Zfish   163 ILGHYLKLPMVYNVRWAGYNEAH--FSIAPSPLSYVPMPSLELSDRMSFLQRVYNVVMYIFIEIG 225

  Fly   214 -----SAAEDLVREFSYYPG-------QDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLA 266
                 |...|.:.|....||       |.|.|..|      ||..:.|.
Zfish   226 AALVISPINDALAERFIGPGTSFLSLVQGADLWLH------RVDFVFEY---------------- 268

  Fly   267 SSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVF 330
             .||...|:|.:.|...:|.|.||:.|:.|:..: .||.|..|||:.:..  ||.:..:...|.|
Zfish   269 -PRPTMPNVIYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLGTLIDK--LPDDVAEAIAEAF 330

  Fly   331 GSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGM 395
            ..|.|:::|:::.:....|..|..:..|:||.|:|.||..:.|:||||..|.|||:|:||||:|.
Zfish   331 AELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGTNGIQEAIYHGVPIIGF 395

  Fly   396 PVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMD 460
            .:..||..|:::.:....|..:|:..:..|.....:.|::.:|.||.|:::.||:.:|.|:..:|
Zfish   396 GLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYRENMQRLSRLHKDVPVKPLD 460

  Fly   461 TAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGL---GLAVILLPIVVLI-----LICRRS 517
            .||:||.:|:.|:||.||......:|||.::.:|::.:   .:::|:|.|..:|     .||.|.
Zfish   461 NAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLIILSIYAVIRYFCCRICMRK 525

  Fly   518 SKPK 521
            :|.|
Zfish   526 TKIK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	144/514 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	145/516 (28%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	140/494 (28%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	146/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585218
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790