DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	550	Identity:	161/550 - (29%)
Similarity:	257/550 - (46%)	Gaps:	56/550 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLLSLVALQQLELGT---GSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFI--TPFSLAKE 68
            |.:||.....:..|:   |.:||.|   |.: ||::..:.:|:.|..|||.|..|  |.....||
Zfish     9 FSVSLWITVMIIFGSLCDGGKILVA---PLEGSHWVNMDILIKALHGQGHTVDVIRNTNSWFVKE 70

  Fly    69 KLGSNYKEIVIPQYDFWPE--IKEMTNKNTVLE------------MTDLPTFAFLRMVNVMGIHT 119
            . .:.|..|.||......|  ::::..|....|            ..|:....:.....|..:.|
Zfish    71 N-STYYNSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKLVCRLIT 134

  Fly   120 TDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIP---TITISTFGNANHLSQL 181
            ..|  |..:|...:.||    ||||:|.:..:..| :||.|..::|   .:..:|.|..:
Zfish   135 NIF--ESEDILKALQEK----KYDLMLTDPGWGTG-IILAHKLKLPMVYNVRWTTPGEGH----- 187

  Fly   182 FGVV-SPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVP 245
            |.:. ||.||:|......||:|:.::|:.||......|........|...|:..|:|...:|
Zfish   188 FDIAPSPMSYIPLTGSGNTDKMSFFQRVINVFYYLLLDFQCSRFNVPQYQALCDKYFDPPVD--- 249

  Fly   246 TIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSL 309
             ..:|.:.....|:.........||...|:|..||....|.|.||..|:.|:..: .||.|..||
Zfish   250 -FYKLLQGADLWLMRVDFVFEFPRPTMPNIIYTGGFQCTPTKPLPHDLEDFMQSSGDHGVIVMSL 313

  Fly   310 GSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFI 374
            ||.:  :.||..........|..|.|:|:|::..:....|..|..:..|:||.|:|.||..|:||
Zfish   314 GSFI--SVLPDYVSSEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKLFI 376

  Fly   375 AHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPK 439
            ||||..|.|||:|:|||::|:|.:.||:.|:.:.::...|..:...::....|...:.|:|..|.
Zfish   377 AHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQEVINEPS 441

  Fly   440 YRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVIL 504
            ||.|::|.|.:.||:|:..:|:||:||.:|:.|:||.||......:|||.::.:|:....:||:|
Zfish   442 YRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVTLIAVVL 506

  Fly   505 LPI----VVLILICRRSSKPKSTPTKKKTK 530
            :.|    |.:..:|     .|....|:||:
Zfish   507 IFIYSMFVTVRYLC-----IKCCSRKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	156/531 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	147/501 (29%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	154/528 (29%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	85/241 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585285
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690