DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	554	Identity:	152/554 - (27%)
Similarity:	265/554 - (47%)	Gaps:	84/554 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSLVALQQLELGTGSRILAAFFFP-GKSHFMMTNAIIRELVKQGHEVT--------FITPFS--- 64
            |.||.:..:|.|.      ...|| ..||::..|.::..|..:||.:|        :|..||
Zfish    16 LLLVTVPVVESGN------VLVFPVDVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHY 74

  Fly    65 ----------LAKEKLGSNYKEI--VIPQYDFWPEIK-EMTNKNTVLEMTDLPTFAFLRMVNVMG 116
                      |:::.:|.....:  ::.:...|..:| |:....|.|:|.::.......|:.
Zfish    75 TSVNLKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQTSLKMIEIEREMITNMIE--- 136

  Fly   117 IHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTI-----TISTFGNAN 176
                    :|..:|::     |..|:||:|.:... .|.::|||..::|.:     ||  ||..:
Zfish   137 --------DQQLMQSL-----KKAKFDLILTDPAM-YGGVMLGHYLKLPIVYNVRWTI--FGEGH 185

  Fly   177 HLSQLFGVV-SPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKL 240
                 |.:. ||.||||...:...|||:..||:.||.|....:....|...|..:|:.::.....
Zfish   186 -----FAIAPSPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCERFIGPE 245

  Fly   241 LDRVPTIKE----LERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA- 300
            ::....::|    |.|   |..:..|     .||...|::.:.|...:|.|.||:.|:.|:..:
Zfish   246 VNFGNLVQEADLWLHR---ADFVFEY-----PRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSSG 302

  Fly   301 THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDIL 365
            .||.|..|||:.:  ..||.:..:...|.|..|.|:::|:::.:....|..|..|..|:||.|:|
Zfish   303 DHGVIVMSLGTLI--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLL 365

  Fly   366 AHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGL 430
            .||..:.|:||||..|.|||:|:||||:|..:..||..|:::.:....|..:|:..:..|.....
Zfish   366 GHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKT 430

  Fly   431 LMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDI 495
            :.|::.:|.||.|:::.||:.:|.|:..:|.||:||.:|:.|:||.||......:|||.::.:|:
Zfish   431 VKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV 495

  Fly   496 VGL---GLAVILLPIVVLI-----LICRRSSKPK 521
            :.:   .:::|:|.|..:|     .||.|::|.|
Zfish   496 ILVLISAVSLIILSIYAVIRYFCCRICMRTTKNK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	147/544 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	141/519 (27%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	148/543 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585212
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790