DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	558	Identity:	155/558 - (27%)
Similarity:	268/558 - (48%)	Gaps:	67/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITP----FSLAK 67
            |.:..|||:.:  ...|....||.  ::...||::....::..|:.:||.||.:.|    |..||
Zfish     3 LVVCFLSLLTV--FSAGQCGNILV--WYTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAK 63

  Fly    68 EKLGSNYKEIVIPQ-----YDFWPEIKEMTNKNTVLEMTDLPTFAFLRM--VNV------MGIHT 119
            |....:|:...:.:     .||:.|:...    :|.|| |..:|..::|  .|:      |.:..
Zfish    64 ESDRFSYQHFSVSKSAQDMQDFFDELMRF----SVFEM-DNSSFLEIQMKFFNLGSQHQDMSLSY 123

  Fly   120 TDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG- 183
            .|..|:.||:.    :|.|.||:|::|::..:....::...| .:|.:....|..|:...::.|
Zfish   124 CDGILKSPELM----DKLKKGKFDVVLSDPMYPCSDIVAEEL-NVPLVYTFRFSVAHAAERMCGQ 183

  Fly   184 VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLV-----REFSYYPGQDAVLKKHFSKLLDR 243
            :.:|.||||.|....||:|:..|||.|:....::|.:     |.|..|          :::...|
Zfish   184 IPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDNY----------YTEYFGR 238

  Fly   244 VPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYF 307
            ..:..|:.......|:.:|......||...|...:||||..|.|.||:.:::|:..: ..|.:.|
Zfish   239 STSYCEMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSGDDGIVVF 303

  Fly   308 SLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKV 372
            :|||.:..  :|.|...........:.|:|||::..|....|..|.::..|:||.|:|.||..:.
Zfish   304 TLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWIPQNDLLGHPKTRA 366

  Fly   373 FIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLD-YRKVTVEELRGLLMELIE 436
            ||.|||..|..||:|:|||::|:|::.||..|:....:...|:.:| .:.:..:||...|..:|.
Zfish   367 FITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVIN 431

  Fly   437 NPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLA 501
            :|.|:.|..:.|||..|||:..:|.:::||.:|:.::||.||.....:|.|||::.||:......
Zfish   432 DPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTT 496

  Fly   502 VILLPIVV--------LILICRRSSKPKSTPTKKKTKK 531
            |:.|.:.:        ::..|.||        |:|:||
Zfish   497 VLTLVLYICFKMAKFFIMRCCFRS--------KRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	148/538 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	141/509 (28%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	147/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860