DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	526	Identity:	146/526 - (27%)
Similarity:	252/526 - (47%)	Gaps:	61/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP----FSLAKEKLGSNYKEIVI-----PQYDFWPEIKEMTN 93
            ||::....::..|:.:||.||.:.|    |..|||....:|:...:     ...||..|:...
Zfish    30 SHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKESDRFSYQNFSVSTSAQDMQDFLDELLHF-- 92

  Fly    94 KNTVLEMTDLPTFAF-LRMVNV------MGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFF 151
              :|.||..|..... ::..::      ||:...|..|:.||:.    :|.|.||:|:||::..:
Zfish    93 --SVFEMEQLNLLQIQMKFFDLGSRHQDMGLSYCDGILKSPELM----DKLKTGKFDVLLSDPMY 151

  Fly   152 NEGALILGHLYQIPTITISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSA 215
             ..:.|:..:..:|.:....|..|:.:.::.| :.:|.||||.|....||:|:..|||.|.....
Zfish   152 -PCSDIVAEVLNVPLVFTLRFSIAHTMERICGQIPAPPSYVPGAMSKLTDKMSFTERIFNTLFYL 215

  Fly   216 AEDLV-----REFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNM 275
            :.|..     ::|..|          :::...|..:..|:.......|:.:|......||...|.
Zfish   216 SMDTFSIIAWKKFDNY----------YTEYFGRPTSYCEMMGRADIWLIRTYWDFEFPRPFVPNF 270

  Fly   276 IPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLW 339
            ..:||||..|.|.||:.:::|:..: ..|.:.|:|||.:..  :|.|...........:.|:|||
Zfish   271 KYIGGLHCTPAKPLPKDMEEFVQSSGDDGIVVFTLGSMIDK--VPKEMSNRIASALAQIPQKVLW 333

  Fly   340 KFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQN 404
            ::..|....|..|.::..|:||.|:|.||..:.||.|||..|..||:|:|||::|:|::.||..|
Zfish   334 RYGGEKPDTLGENTRIYKWMPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDN 398

  Fly   405 INQGKSAEYALGLD-YRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINY 468
            :....:...|:.:| .:.:..:||...|..:|.:|.|:.|..:.|||..|||:..:|.:::||.:
Zfish   399 MVHMTTRGAAVVVDSIKSMQPQELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEF 463

  Fly   469 VIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVV--------LILICRRSSKPKSTPT 525
            |:.::||.||.....:|.|||::.||:......|:.|.:.:        ::..|.||
Zfish   464 VMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTVLTLVLYICFKMAKFFIMRCCFRS-------- 520

  Fly   526 KKKTKK 531
            |:|:||
Zfish   521 KRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	139/506 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	139/508 (27%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	143/521 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585266
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690