DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNA6 and kcna6a

DIOPT Version :9

Sequence 1:	NP_002226.1	Gene:	KCNA6 / 3742	HGNCID:	6225	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_001124098.1	Gene:	kcna6a / 795490	ZFINID:	ZDB-GENE-080722-21	Length:	475	Species:	Danio rerio

Alignment Length:	469	Identity:	304/469 - (64%)
Similarity:	357/469 - (76%)	Gaps:	60/469 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    19 EGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNE 83
            |.||.|.          .||  |.:.||||||||||||:||:.:|:||||||.:|:|||||||||
Zfish    21 EMEQSDQ----------ECC--ELVTINISGLRFETQLKTLARYPNTLLGDPIKRMRFFDPLRNE 73

Human    84 YFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDE 148
            :|||||||||||||||||||||||||:|||:|:||:||:||::||:.:..|:||||.|.   |||
Zfish    74 FFFDRNRPSFDAILYYYQSGGRLRRPINVPVDMFLDEIKFYEIGDDVIKHFQEDEGLLK---EDE 135

Human   149 KPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSR 213
            :||||..|:||:|||||:|:|||.||.||||||:||||||:|||:||||:||
Zfish   136 RPLPSNEFKRQIWLLFEHPDSSGAARIIAIVSVMVILISIIIFCIETLPEFR------------- 187

Human   214 VSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFEL 278
                          |||....:|      :....::|:..|  |.:||||||:||:|||||.|||
Zfish   188 --------------EDDRVFDNH------LPANSTTSVQRL--SAYTDPFFLLETICIVWFCFEL 230

Human   279 LVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRV 343
            .:||.||||||.||::|||.||:|||.||||||..||.:.|..|          ||..|||||||
Zfish   231 FIRFLACPSKPTFFKDIMNTIDIVAIMPYFITLSLELGEVQSNQ----------QQTTSLAILRV 285

Human   344 IRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPS 408
            |||||||||||||||||||||||:||:|||||||||||||.||:||||||||||||||.::.|.|
Zfish   286 IRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLIIGIILFSSAVYFAEADDPETSFTS 350

Human   409 IPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEE 473
            ||||||||||:|||||||||||:|:|||||||:|||||||||||||||||||||||||||..:.:
Zfish   351 IPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSMCAIAGVLTIALPVPVIVSNFNYFYHREHNEAD 415

Human   474 QGQYTHVTCGQPAP 487
            |.:|||||||:..|
Zfish   416 QVEYTHVTCGRSLP 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA6	NP_002226.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		4/13 (31%)
		BTB_POZ_KCNA6	41..170	CDD:349714	91/128 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..233		3/22 (14%)
		Ion_trans	258..468	CDD:366146	163/209 (78%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	360..373		10/12 (83%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	422..427		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..513		304/469 (65%)
		PDZ-binding. /evidence=ECO:0000255	527..529
kcna6a	NP_001124098.1	BTB	33..122	CDD:197585	68/88 (77%)
		BTB_2	33..121	CDD:280393	68/87 (78%)
		Ion_trans	211..411	CDD:278921	164/209 (78%)
		Ion_trans_2	<350..401	CDD:285168	46/50 (92%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	9	9.230