DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNA6 and Shawl

DIOPT Version :9

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:581 Identity:188/581 - (32%)
Similarity:274/581 - (47%) Gaps:155/581 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    42 RLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 106
            |:::|:||:|:||...||...|.|.|......:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Human   107 RRPVNVPLDIFLEEIRFYQLGDEAL--------AAFREDEGCL----PEGGEDEKPLPSQ----- 154
            ..|.:|...:|.||:.|:.|....:        :..|:.:..|    ....|:|||...|     
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Human   155 ------------PFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVD-- 202
                        .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||||  
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

Human   203 ---------GRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFH-HGITP--GEMG----------- 244
                     |.||...|   ..|:....|        ::.:| |.|||  |.:|           
  Fly   200 SGAHDAHGPGAGGPPHG---HDPMGEPPQ--------THQYHQHSITPPSGSIGPTFRVTNYTSY 253

Human   245 -------TGGSSSLST------------LGGSFFT--------------------------DPFF 264
                   :|.::.::|            :.||...                          :.||
  Fly   254 SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318

Human   265 LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG 329
            .||.:|.|||..|:::|....|:...|.::.:||||..|...::    |:::|:.        |.
  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRM--------GE 371

Human   330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAV 394
            ..|       :|....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|::.|:|..
  Fly   372 YTG-------LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLA 429

Human   395 YFAE--ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVI 457
            |:||  .|:.|:.|.|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||
  Fly   430 YYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494

Human   458 VSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHR 518
            ||||:.|            |:|.......|..|.....:.:|     .|:|.|:   .|||
  Fly   495 VSNFSMF------------YSHTQARSKLPKKRRRVLPVEQP-----RRKREPT---APHR 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 47/159 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 3/22 (14%)
Ion_trans 258..468 CDD:366146 96/237 (41%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 5/24 (21%)
PDZ-binding. /evidence=ECO:0000255 527..529
ShawlNP_001097131.2 BTB 7..99 CDD:197585 34/92 (37%)
BTB_2 7..97 CDD:280393 34/90 (38%)
Ion_trans 307..506 CDD:278921 98/229 (43%)
Ion_trans_2 <449..499 CDD:285168 37/49 (76%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.