DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA6 and Shawl

DIOPT Version :10

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:581 Identity:188/581 - (32%)
Similarity:274/581 - (47%) Gaps:155/581 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    42 RLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 106
            |:::|:||:|:||...||...|.|.|......:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Human   107 RRPVNVPLDIFLEEIRFYQLGDEAL--------AAFREDEGCL----PEGGEDEKPLPSQ----- 154
            ..|.:|...:|.||:.|:.|....:        :..|:.:..|    ....|:|||...|     
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Human   155 ------------PFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVD-- 202
                        .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||||  
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

Human   203 ---------GRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFH-HGITP--GEMG----------- 244
                     |.||...|   ..|:....|        ::.:| |.|||  |.:|           
  Fly   200 SGAHDAHGPGAGGPPHG---HDPMGEPPQ--------THQYHQHSITPPSGSIGPTFRVTNYTSY 253

Human   245 -------TGGSSSLST------------LGGSFFT--------------------------DPFF 264
                   :|.::.::|            :.||...                          :.||
  Fly   254 SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318

Human   265 LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG 329
            .||.:|.|||..|:::|....|:...|.::.:||||..|...::    |:::|:.        |.
  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRM--------GE 371

Human   330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAV 394
            ..|       :|....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|::.|:|..
  Fly   372 YTG-------LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLA 429

Human   395 YFAE--ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVI 457
            |:||  .|:.|:.|.|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||
  Fly   430 YYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494

Human   458 VSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHR 518
            ||||:.|            |:|.......|..|.....:.:|     .|:|.|:   .|||
  Fly   495 VSNFSMF------------YSHTQARSKLPKKRRRVLPVEQP-----RRKREPT---APHR 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 47/159 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 3/22 (14%)
Ion_trans 259..468 CDD:459842 96/236 (41%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 5/24 (21%)
PDZ-binding. /evidence=ECO:0000255 527..529
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 37/109 (34%)
Ion_trans 307..506 CDD:459842 98/229 (43%)
Blue background indicates that the domain is not in the aligned region.

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