DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNA6 and Shab

DIOPT Version :9

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster


Alignment Length:480 Identity:166/480 - (34%)
Similarity:241/480 - (50%) Gaps:127/480 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    40 SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVR-------------FFDPLRNEYFFDRNRP 91
            :.|:.||:.|:|.|...|||...|.|.||    |:|             .:....|||||||:..
  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPK 366

Human    92 SFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFY------------------------QLGDEALA 132
            ||.:||.:|:: |:|.....:.:..|.:::.::                        ::..||.:
  Fly   367 SFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAES 430

Human   133 AFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP 197
            ..:.||....||...|       :|:.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
  Fly   431 LRQRDEEEFGEGKCAE-------YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488

Human   198 QFR-VDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTD 261
            |.: :|     ||                             ||.:                 ..
  Fly   489 QLQHID-----NG-----------------------------TPQD-----------------NP 502

Human   262 PFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITL--------GTELVQQ 318
            ...:||.:||.|||.|.::||||.|.|..||:..:|||||:||.|||::|        .|:..|.
  Fly   503 QLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQD 567

Human   319 QEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFL 383
            ..:                  :::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||
  Fly   568 VRR------------------VVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFL 614

Human   384 FIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVL 448
            .:||::|||..||||.|:.|:.|.|||:.||||.:|||||||||:||.|..||::|::|.|.|||
  Fly   615 AMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVL 679

Human   449 TIALPVPVIVSNFNYFYHRETEQEE 473
            .||||:|:||:||..||..:..:|:
  Fly   680 VIALPIPIIVNNFAEFYKNQMRREK 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 42/165 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 0/22 (0%)
Ion_trans 258..468 CDD:366146 104/217 (48%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513
PDZ-binding. /evidence=ECO:0000255 527..529
ShabNP_001189037.1 BTB 309..416 CDD:197585 29/111 (26%)
BTB_2 309..408 CDD:280393 29/103 (28%)
Ion_trans 501..700 CDD:278921 104/216 (48%)
Ion_trans_2 613..696 CDD:285168 50/82 (61%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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