DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA6 and KCNQ

DIOPT Version :10

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:431 Identity:103/431 - (23%)
Similarity:160/431 - (37%) Gaps:131/431 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    78 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALA 132
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52

Human   133 AFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP 197
            .:|.                   .|.:::...|.|      ||:..:...|::..:|..||    
  Fly    53 RYRR-------------------LQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCL---- 88

Human   198 QFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDP 262
                              .:|..|..:|.:||..|.                             
  Fly    89 ------------------ALSVFSTIKEYEEDAVYI----------------------------- 106

Human   263 FFLVETLCIVWFTFEL---------LVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQ 318
            .|.:|.|.::|||.|.         ..|:..|..:..|.:....|||:|.|....:.||.     
  Fly   107 LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM----- 166

Human   319 QEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFL 383
                      |.:| |..:.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..
  Fly   167 ----------GTSG-QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIG 220

Human   384 FIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVL 448
            |:|:|..|..||..|.|.:|. |.:...|.||.|:|:.|||||||.|:|..||::.|.||:.|:.
  Fly   221 FLGLIFASFLVYMWEKDVNDK-FSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGIS 284

Human   449 TIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDL 489
            ..|||..::.|.|..     ..|::|.|...:...|||..|
  Fly   285 FFALPAGILGSGFAL-----KVQQQQRQKHMIRRRQPAATL 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 19/101 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 5/22 (23%)
Ion_trans 259..468 CDD:459842 65/217 (30%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 3/12 (25%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 1/2 (50%)
PDZ-binding. /evidence=ECO:0000255 527..529
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 76/305 (25%)
KCNQ_channel <619..719 CDD:460954
Blue background indicates that the domain is not in the aligned region.

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