DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA6 and Shaw

DIOPT Version :10

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:523 Identity:183/523 - (34%)
Similarity:254/523 - (48%) Gaps:122/523 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    39 SSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSG 103
            |..|:|:|:.|:|.||...||...|.|.|......:..:||:.|||||||:...|..:|.||:: 
  Fly    23 SENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT- 86

Human   104 GRLRRPVNVPLDIFLEEIRFYQLG------------------DEALAAF----------REDEGC 140
            |:|..|.:|...:|.||:.|:.|.                  .|.||..          .|:|..
  Fly    87 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELA 151

Human   141 LPEGGEDE--KPLPS--QPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRV 201
            ...|.|::  |...|  |..:.::|.||:.|.||..|:.|.:|||..|.|||:.|||:|.|..||
  Fly   152 RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRV 216

Human   202 DGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGS--FFTD--- 261
                          |:.|                            :.::.|..||  :|.|   
  Fly   217 --------------PIVR----------------------------NITVKTANGSNGWFLDKTQ 239

Human   262 -----PFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQ 321
                 .||.:|.:|..|||||:||||.:.|:|..|.::.:||||.:|...::|    :||.|   
  Fly   240 TNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYI----DLVLQ--- 297

Human   322 QPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIG 386
                    :......:..||....::|:.|:|||:|||.||:||.:|.:||.:||.||:|||.:|
  Fly   298 --------RFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLG 354

Human   387 VILFSSAVYFAE--ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT 449
            :::|:|.||:||  ..:..:.|.|||...|||:|||||||||||.|.|..|..||:|||:|||||
  Fly   355 IVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLT 419

Human   450 IALPVPVIVSNFNYFY-HRE--------------TEQEEQGQYTHVT-----CGQPAPDLRATDN 494
            ||||||||||||..:| |.:              .||..|.:.....     ||.|.....:...
  Fly   420 IALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPM 484

Human   495 GLG 497
            |.|
  Fly   485 GSG 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 48/160 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 2/22 (9%)
Ion_trans 259..468 CDD:459842 103/219 (47%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 2/10 (20%)
PDZ-binding. /evidence=ECO:0000255 527..529
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 37/111 (33%)
Ion_trans 188..439 CDD:459842 124/307 (40%)
PRK14959 <418..>585 CDD:184923 24/70 (34%)
Blue background indicates that the domain is not in the aligned region.

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