DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA6 and Sh

DIOPT Version :10

Sequence 1:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens
Sequence 2:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster


Alignment Length:534 Identity:315/534 - (58%)
Similarity:372/534 - (69%) Gaps:92/534 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    18 PEGEQQDAGDFPEAGG-----GGG-------------CCSSERLVINISGLRFETQLRTLSLFPD 64
            |:...||     |.||     |||             |   ||:|||:||||||||||||:.|||
  Fly    64 PKLSSQD-----EEGGAGHGFGGGPQHFEPIPHDHDFC---ERVVINVSGLRFETQLRTLNQFPD 120

Human    65 TLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDE 129
            ||||||.||:|:||||||||||||:||||||||||||||||||||||||||:|.|||:||:|||:
  Fly   121 TLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQ 185

Human   130 ALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLE 194
            |:..||||||.:.   |:|:|||....||:|||||||||||..||.:||:||.|||:||||||||
  Fly   186 AINKFREDEGFIK---EEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLE 247

Human   195 TLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFF 259
            |||:|:         .....:..:.|::.||::..|                            .
  Fly   248 TLPEFK---------HYKVFNTTTNGTKIEEDEVPD----------------------------I 275

Human   260 TDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQE---- 320
            ||||||:|||||:||||||.|||.|||:|..|.|::||:||::||.||||||.|.:.::::    
  Fly   276 TDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNL 340

Human   321 -QQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLF 384
             :.|.| ...::..|||||||||||||||||||||||||||||||||:||:||||||||||||||
  Fly   341 PKAPVS-PQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLF 404

Human   385 IGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT 449
            |||:|||||||||||..::|.|.|||||||||||||||||||||.|:.|.|||||||||||||||
  Fly   405 IGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLT 469

Human   450 IALPVPVIVSNFNYFYHRETEQEE-QGQ-YTHVT-C----------------GQPAPDLRATDNG 495
            ||||||||||||||||||||:||| |.| :.||| |                .:.:.|:...|:|
  Fly   470 IALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDG 534

Human   496 L-GKPDFPEANRER 508
            : ..|...|.:..|
  Fly   535 VESTPGLTETHPGR 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 4/14 (29%)
BTB_POZ_KCNA6 41..170 CDD:349714 99/128 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 4/22 (18%)
Ion_trans 259..468 CDD:459842 161/213 (76%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 6/22 (27%)
PDZ-binding. /evidence=ECO:0000255 527..529
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 99/128 (77%)
Ion_trans 226..488 CDD:459842 186/299 (62%)
Blue background indicates that the domain is not in the aligned region.

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