Protein Alignment KCNA6 and CG43155

DIOPT Version :10

• Sequence 1: NP_002226.1
• Gene: KCNA6 / 3742
• HGNCID: 6225
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 256
• Identity: 56/256 - (21%)
• Similarity: 98/256 - (38%)
• Gaps: 72/256 - (28%)

Human   216 PVSRGSQEEEEDEDDSYT-----FHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 275
            |:.:.:.:|.:.:|::.|     ..|.....:...||..:..|.||.        ..|.|  |.:
  Fly     2 PMKKVTVKEYDSQDEASTELLEKLKHLDRRVDAAEGGGLAKGTAGGR--------RSTAC--WQS 56

Human   276 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI 340
            .:              :::.:|.|.|:.....:..:| .|:.:..::||
  Fly    57 MK--------------WKSALNHIGLLVSLSIYCGVG-GLIFRHLERPA---------------- 90

Human   341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE------- 398
             .|.||..:..|.|..|......||..|...::.||      |...:..:.:||..|.
  Fly    91 -EVERLSHLKDIVKTHRERFLHTILNNTEVHNLDEL------LSFELAKYEAAVQQAAEGGLLIV 148

Human   399 ADDDDSLFP------SIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGV---LTI 450
            ||.|   ||      ||..|.:::...:||:|||::.|:|.||::.....|:.|:   ||:
  Fly   149 ADKD---FPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIPFTLTV 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA6	NP_002226.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		BTB_POZ_KCNA6	41..170	CDD:349714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..233		3/16 (19%)
		Ion_trans	259..468	CDD:459842	46/208 (22%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	360..373		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	422..427		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	21/67 (31%)
		Ion_trans_2	<267..319	CDD:462301