Protein Alignment KCNA6 and Ork1

DIOPT Version :10

• Sequence 1: NP_002226.1
• Gene: KCNA6 / 3742
• HGNCID: 6225
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 148
• Identity: 27/148 - (18%)
• Similarity: 53/148 - (35%)
• Gaps: 60/148 - (40%)

Human   378 LLIFFLFIGVILFSSAVYF-----------AE--------------------------------- 398
            :|:...:|..::|.:|:|:           ||
  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISD 71

Human   399 -ADDDDSLFPSIPD---------AFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALP 453
             .|...:|.|:..|         ||::|....:|||||::.|.|..|:::....::.|:     |
  Fly    72 YCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI-----P 131

Human   454 V-PVIVSNFNYFYHRETE 470
            | .::.:....::.|..|
  Fly   132 VNGILFAGLGEYFGRTFE 149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA6	NP_002226.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		BTB_POZ_KCNA6	41..170	CDD:349714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..233
		Ion_trans	259..468	CDD:459842	25/144 (17%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	360..373
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	422..427		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	15/65 (23%)
		Ion_trans_2	185..266	CDD:462301