DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lapsyn and TLR3

DIOPT Version :9

Sequence 1:NP_611561.1 Gene:Lapsyn / 37418 FlyBaseID:FBgn0034602 Length:343 Species:Drosophila melanogaster
Sequence 2:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens


Alignment Length:300 Identity:71/300 - (23%)
Similarity:125/300 - (41%) Gaps:81/300 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 GFIIQSEVRKCTYGH--IDKLLRIRCYDLDLKEVPQNLKSSVEVLDLSHNRIRKLKTSSFQRYTD 83
            |.:..|...|||..|  .|      |..|.|.:||.:|.:::.||:|:||::|:|..::|.||:.
Human    18 GMLCASSTTKCTVSHEVAD------CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ 76

  Fly    84 ------------------------IKFLMLYDNMILSVEVGTFEPLTSLQE-------------- 110
                                    :|.|.|..|.:..:...||...|:|.|              
Human    77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNN 141

  Fly   111 ----------IDLSNNGLTTIPL-ELFQLPRLRNLYIDSNELTSLNLQALEKPIRAPLEYLNVAG 164
                      :|||:|||::..| ...||..|:.|.:.:|::.:|..:.|:....:.|:.|.::.
Human   142 PFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 206

  Fly   165 CELQELPD-----LGILPKLWQLNASMNPLQNFRID-SLANMCHLQVIDLTKSQLSQCGCQQVTN 223
            .:::|...     :|.|..|:..|..:.|....::. .||| ..::.:.|:.||||      .|:
Human   207 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELAN-TSIRNLSLSNSQLS------TTS 264

  Fly   224 HLMMLGASPKFVPVCLEALDIRECPLPYN--RTIHSPTFA 261
            :...||         |:..::....|.||  ..:.:.:||
Human   265 NTTFLG---------LKWTNLTMLDLSYNNLNVVGNDSFA 295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LapsynNP_611561.1 leucine-rich repeat 39..59 CDD:275380 6/19 (32%)
LRR_8 58..118 CDD:290566 23/107 (21%)
leucine-rich repeat 60..83 CDD:275380 10/22 (45%)
leucine-rich repeat 84..107 CDD:275380 6/22 (27%)
LRR_RI <94..>249 CDD:238064 39/185 (21%)
LRR_8 106..167 CDD:290566 19/85 (22%)
LRR_4 106..145 CDD:289563 15/63 (24%)
leucine-rich repeat 108..130 CDD:275380 11/46 (24%)
leucine-rich repeat 131..154 CDD:275380 5/22 (23%)
leucine-rich repeat 157..178 CDD:275380 5/25 (20%)
leucine-rich repeat 179..202 CDD:275380 6/23 (26%)
TLR3NP_003256.1 LRRNT 28..50 CDD:396168 9/27 (33%)
leucine-rich repeat 33..52 CDD:275380 7/24 (29%)
LRR 1 52..73 8/20 (40%)
leucine-rich repeat 53..76 CDD:275380 10/22 (45%)
PLN00113 72..>542 CDD:215061 49/239 (21%)
LRR 2 76..97 0/20 (0%)
leucine-rich repeat 77..100 CDD:275380 0/22 (0%)
LRR 3 100..121 6/20 (30%)
leucine-rich repeat 101..124 CDD:275380 6/22 (27%)
LRR 4 124..145 2/20 (10%)
leucine-rich repeat 125..148 CDD:275380 2/22 (9%)
LRR 5 148..168 7/19 (37%)
leucine-rich repeat 149..198 CDD:275380 14/48 (29%)
LRR 6 172..193 5/20 (25%)
LRR 7 198..219 3/20 (15%)
leucine-rich repeat 199..249 CDD:275380 11/50 (22%)
LRR 8 222..244 4/21 (19%)
LRR 9 249..270 6/26 (23%)
leucine-rich repeat 250..275 CDD:275380 9/39 (23%)
LRR 10 275..296 4/20 (20%)
leucine-rich repeat 276..299 CDD:275380 4/19 (21%)
LRR 11 299..320
leucine-rich repeat 300..321 CDD:275380
LRR 12 323..344
LRR 13 356..377
leucine-rich repeat 357..380 CDD:275380
LRR 14 380..400
leucine-rich repeat 381..406 CDD:275380
LRR 15 408..429
leucine-rich repeat 409..432 CDD:275380
LRR 16 432..454
leucine-rich repeat 433..457 CDD:275380
leucine-rich repeat 458..481 CDD:275380
LRR 17 465..486
leucine-rich repeat 482..507 CDD:275380
LRR 18 507..528
leucine-rich repeat 508..531 CDD:275380
LRR 19 531..552
leucine-rich repeat 532..563 CDD:275380
LRR_8 562..622 CDD:404697
LRR 20 563..584
leucine-rich repeat 564..585 CDD:275380
LRR 21 587..608
leucine-rich repeat 588..611 CDD:275380
LRR 22 611..632
leucine-rich repeat 612..630 CDD:275380
leucine-rich repeat 637..659 CDD:275380
LRRCT 645..697 CDD:214507
Tlr3_TMD 698..730 CDD:407816
TIR 755..900 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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