DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lapsyn and islr2

DIOPT Version :9

Sequence 1:	NP_611561.1	Gene:	Lapsyn / 37418	FlyBaseID:	FBgn0034602	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	184	Identity:	57/184 - (30%)
Similarity:	83/184 - (45%)	Gaps:	34/184 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RKCT----YGH--IDKLLRIRCYDLDLKEVPQNLKSSVEVLDLSHNRIRKLKTSSFQRYTDIKFL 87
            ::|.    |.|  :|      |...||.|||..|.|:...|.||.|:|:.||:.:|...|.:..|
Zfish    24 KQCACSDKYNHQFVD------CAYKDLVEVPVGLPSNASTLSLSANKIKVLKSKTFVNVTQVTSL 82

  Fly    88 MLYDNMILSVEVGTFEPLTSLQEIDLSNNGLTTIPLE-LFQLPRLRNLYIDSNELTSLNLQALEK 151
            .|..|.|::||..|..||..|:.:|:|||.:...|.| |..|..|:.|.:::||:.|:...|..
Zfish    83 WLAHNEIITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFS- 146

  Fly   152 PIRAPLEYLNVAGCELQELPDLGILPKLWQLNASMNPLQNFRIDSLANMCHLQV 205
                          .|::|..:.|      .|.....:.....||||.|.|||:
Zfish   147 --------------NLKDLRSIRI------NNNKFTTIVQGTFDSLAAMSHLQI 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lapsyn	NP_611561.1	leucine-rich repeat	39..59	CDD:275380	7/19 (37%)
		LRR_8	58..118	CDD:290566	24/59 (41%)
		leucine-rich repeat	60..83	CDD:275380	8/22 (36%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		LRR_RI	<94..>249	CDD:238064	33/113 (29%)
		LRR_8	106..167	CDD:290566	15/61 (25%)
		LRR_4	106..145	CDD:289563	14/39 (36%)
		leucine-rich repeat	108..130	CDD:275380	9/22 (41%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..178	CDD:275380	3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	8/23 (35%)
		LRR_RI	<47..>184	CDD:238064	49/155 (32%)
		LRR_8	53..113	CDD:290566	24/59 (41%)
		leucine-rich repeat	57..78	CDD:275380	8/20 (40%)
		leucine-rich repeat	79..102	CDD:275380	9/22 (41%)
		LRR_8	102..161	CDD:290566	19/79 (24%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		leucine-rich repeat	127..150	CDD:275380	7/37 (19%)
		leucine-rich repeat	151..174	CDD:275380	6/28 (21%)
		LRRCT	183..>221	CDD:214507
		IG_like	252..345	CDD:214653
		Ig	256..345	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910