Protein Alignment Lapsyn and FMOD

DIOPT Version :10

• Sequence 1: NP_611561.1
• Gene: Lapsyn / 37418
• FlyBaseID: FBgn0034602
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_002014.2
• Gene: FMOD / 2331
• HGNCID: 3774
• Length: 376
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 74/327 - (22%)
• Similarity: 124/327 - (37%)
• Gaps: 86/327 - (26%)

  Fly    44 CYDLDLKEVPQNLKSSVEVLDLSHNRIRKLKTSSFQRYTDIKFLMLYDNMILSVEVG--TFEPLT 106
            |.:.:||.:| .:.|.::.:...:|:|..::...|...|.:.::.|:.|.|.|.:||  .|..|.
Human    92 CDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLR 155

  Fly   107 SLQEIDLSNNGLTTIPLELFQLPR-LRNLYIDSNELTSLNLQALEKPIRAPLEYLNVAGCELQEL 170
            .|:.:.|.:|.||.:|   ..||| ||.|::|.|:::.:...|||     .||.|.....:..|:
Human   156 HLERLYLDHNNLTRMP---GPLPRSLRELHLDHNQISRVPNNALE-----GLENLTALYLQHNEI 212

  Fly   171 PDLGILPKLWQLNASMNPLQNFRIDSLANMCHLQVIDLTKSQLSQC--GCQQVTNHLMM------ 227
            .::|         :||..|::           |.::||:.:.|.:.  |.......|.|
Human   213 QEVG---------SSMRGLRS-----------LILLDLSYNHLRKVPDGLPSALEQLYMEHNNVY 257

  Fly   228 ------LGASPKFVPVCL---------------EALDIRECPLPYNRTIHSPTFASCQTTLQ--F 269
                  ...:||.:.|.|               .:..:.|..|.||:....|   ...|.|:  :
Human   258 TVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIP---PVNTNLENLY 319

  Fly   270 AETRSFWLFGAGCFGGVCFVLLIVIFCVIHCRRKRAQRRKRNAQKRKPFVISPRNAINNRQPEDE 334
            .:......|....|   |.|:.:|.|..:...|......||:|                 .|.|.
Human   320 LQGNRINEFSISSF---CTVVDVVNFSKLQVLRLDGNEIKRSA-----------------MPADA 364

  Fly   335 PL 336
            ||
Human   365 PL 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lapsyn	NP_611561.1	LRR	<34..>214	CDD:443914	45/172 (26%)
		leucine-rich repeat	39..59	CDD:275380	4/14 (29%)
		leucine-rich repeat	60..83	CDD:275380	3/22 (14%)
		leucine-rich repeat	84..107	CDD:275380	8/24 (33%)
		leucine-rich repeat	108..130	CDD:275380	7/21 (33%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	157..178	CDD:275380	5/20 (25%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
FMOD	NP_002014.2	LRRNT	75..109	CDD:214470	5/17 (29%)
		LRR	<105..354	CDD:443914	63/282 (22%)
		LRR 1	106..127		3/20 (15%)
		leucine-rich repeat	107..130	CDD:275380	3/22 (14%)
		LRR 2	130..151		6/20 (30%)
		leucine-rich repeat	131..156	CDD:275380	8/24 (33%)
		LRR 3	156..176		7/22 (32%)
		leucine-rich repeat	157..177	CDD:275380	8/22 (36%)
		LRR 4	177..198		8/25 (32%)
		leucine-rich repeat	178..201	CDD:275380	9/27 (33%)
		LRR 5	201..222		5/29 (17%)
		leucine-rich repeat	202..224	CDD:275380	6/30 (20%)
		LRR 6	224..245		5/31 (16%)
		leucine-rich repeat	225..245	CDD:275380	5/19 (26%)
		leucine-rich repeat	246..269	CDD:275380	2/22 (9%)
		LRR 7	246..266		2/19 (11%)
		LRR 8	269..289		3/19 (16%)
		leucine-rich repeat	270..314	CDD:275380	7/46 (15%)
		LRR 9	294..315		6/23 (26%)
		leucine-rich repeat	315..334	CDD:275380	3/21 (14%)
		LRR 10	316..335		2/21 (10%)
		LRR 11	344..365		6/37 (16%)