DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and tdrd6

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	XP_694024.6	Gene:	tdrd6 / 565665	ZFINID:	ZDB-GENE-041001-210	Length:	2117	Species:	Danio rerio

Alignment Length:	1720	Identity:	362/1720 - (21%)
Similarity:	647/1720 - (37%)	Gaps:	481/1720 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   956 GYAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYV---SLDKPYALQEMKTPSK 1017
            |:|:|....: .::..:.|.::|...||:...||   ...||.:.:   ...:.|...|::|.:.
Zfish   184 GFAKKLYSDQ-FMEFVVRSLQASTGTSDLKRISS---IRTKPVEIIEQKEKQQAYMFPELQTDTV 244

  Fly  1018 EAASLSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDN----- 1077
            |...::...|||:.:...|..|.:...:...:.::|        :.:|||...   |.:|
Zfish   245 ETVVITEVTSPFRIFCQLKVFSQELKKLTEQITQYY--------EGRVGSYFA---RAENLGSPC 298

  Fly  1078 -----------AILRATVTACNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSF 1131
                       ::|:..::|.|.:    .|..||.|....|..|::..|...|...|.:.:.||.
Zfish   299 ASRGSDGKWYRSVLQQVMSANNVV----EVLHVDYGKKQFVQVENVKPLASEFFRMPVVTYVCSL 359

  Fly  1132 HSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQGSN-TSSTCSYTVNIFVNGASLRDMLV 1195
            |.:|                                ::|.. |:|...|..::.:|    |.::.
Zfish   360 HGIV--------------------------------DKGVGWTASQIDYLKSLLLN----RTVIA 388

  Fly  1196 KAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDD----AKF-VKSN 1255
            |.:: ..::..:....|.|::    .|:|..:...|.:          |:.|.    |.| |:.:
Zfish   389 KFQY-QSLSEGVHYVTLYGEE----NTNINKLFELKPK----------CSLDSDMTLADFAVQKS 438

  Fly  1256 PN-----LARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALV 1315
            |:     ::|..:..:..::::            .|:...|:|..:.   :.|.    |:..|:|
Zfish   439 PSSQKSKISRTTESTHINETYS------------DLKVNKPVFFTET---LTPN----STHMAVV 484

  Fly  1316 VYTAKPYRVYVQPQAIVPSMQTL---LDNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYRARIS 1377
            .:...|.:.::|.|........|   |.|:|....:....::|..||.|||.::.||.:|||.:.
Zfish   485 QHVDSPGKFWIQTQRYADEFDLLMNGLGNLYSDPTSTESLIRKPVVGLICAAKAQDGVFYRAAVY 549

  Fly  1378 GKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRPSNDTKLKARISEI 1442
            ......|  ||:::||||||.:...:::.|..:| :.....||:.:|...:|    :||     :
Zfish   550 KVIDKTA--EVYFLDYGNTEVVDSFNLRQLPLRF-QQLPAVAVKCSLHGVKP----RLK-----L 602

  Fly  1443 LEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIET 1507
            .||:....      .|.|:.|.|:                   ||....||.:.      ..::.
Zfish   603 WEERATLF------FSKLVRDRII-------------------DLHVQDKQQDT------HIVQL 636

  Fly  1508 VDLTLDEEEDKGRKETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVP 1572
            ||.:||.|:|      |||. ..||.....:.:..|....:|             ..|||
Zfish   637 VDPSLDGEKD------VSKL-LCNAGFAVSEKSIVDYSATRS-------------CGLKT----- 676

  Fly  1573 AEPAPV----PKPATPVPEVVEVPEINPTVREAAAESKQAPAQEDPY-----KDLDCVVLSHCDN 1628
            ...:.|    .:|.||....|        |.::|:..|:       |     ..|: |.:|:.:|
Zfish   677 THASGVFLTGTQPQTPCSSSV--------VMDSASAFKE-------YLFPIGSSLE-VTVSYIEN 725

  Fly  1629 PAQFYVHPIDQLSKLNQLHENLQIV---SPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAEL- 1689
            |..|:.......:.|..|.:::|..   |...|.|     .|.||:.:.....||||.:|....
Zfish   726 PNDFWCQKARNAACLEVLMQDIQRFYSHSEFEPLL-----EAACVARHPETGIWYRALVIQKHQT 785

  Fly  1690 --MVLLFIDYGNTDCVSDATDIKESMWSHIEPFCLP-------CAL--PIRP--KGTADWVDAAN 1741
              :.:||||||.|..|: ..|:::     |.|..|.       |:|  .|.|  ..::||...|.
Zfish   786 PHVDVLFIDYGQTKKVA-IEDLRK-----ITPAFLKMKGQAFRCSLYNLIHPVLHSSSDWSTEAT 844

  Fly  1742 GIFNESYSKVPRLEYLTQGDHYTTSY---------VNMYIDGEDVAKKLI--------------- 1782
            ..|.|.......:....:...:...|         |::....:.:...|:
Zfish   845 LEFQEFVDAAASMNVPLKCTIFAVMYDSQKVVFNVVDLETPFQSICNLLVQRRLADRAPSKRSPL 909

  Fly  1783 ----ADGFARPLEYLASGC--SCYISHVNGICDFFIQLERDS----KALELIELYLRKKDTLKPL 1837
                .|.:......:.:||  ...|:.|.|:..||..|.|:|    |..|.:.....:.:..|..
Zfish   910 PPFRLDTYYYSTHGVKTGCDEKVSITCVKGVNQFFCHLARNSDEVEKLAEKVNFLCHQLEATKCP 974

  Fly  1838 EGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLML-----SEEIASLP 1897
            :.|  |.:..|.:.|. ||||.|::...|.  ..:.|:|||:|....|..:|     :.:|.|:|
Zfish   975 QTF--GTVCFAKYTDG-LWYRGQIKSTKPS--VVINFVDYGDTLEVDKSDLLPVPIEAGDIMSVP 1034

  Fly  1898 SLSKKCSL-----QLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENII 1957
            ..:.:|.|     :||....:|.    .|||:     ...||..::........|..|.||:..:
Zfish  1035 VQAIECGLSDMPEELPCEVDNWF----RKFAD-----SHCFTALIVAKEPAGKLILELYDGKTQV 1090

  Fly  1958 DRLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIY-LQFSEKDSLMDIICEKLNGSKLQPKT 2021
            :.|:   ::|...|..|..            .:|.:|| |:....:|:....|:|  .|...||.
Zfish  1091 NALI---KQKFHNEIHKND------------ASTFKIYGLKSRAAESVEASACKK--ESSTGPKR 1138

  Fly  2022 EKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLYELP--QEFTLIKPVA 2084
            :  |:|                                            ::|  :|...|:...
Zfish  1139 D--AID--------------------------------------------QVPKSRESHAIQRSN 1157

  Fly  2085 EICSMEPSAI--FEKNKALTLTTFDALLDSCKGVVAVEFVN-------KSASPPVVRLTTKDKRS 2140
            ::.|.:|.:.  |..|.....|.....:::|:....:....       .|:.|.||:  .|.:..
Zfish  1158 DVASKQPQSRWGFSTNGRPEPTRDSGTINNCQKQPELRTSQGNLRHPCTSSKPEVVK--PKPQAL 1220

  Fly  2141 LKIYEHLQKLVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLK 2205
            ||......|.::..|:        :|..||:.|||.||:||.   :.|.|.|...::.|..::.:
Zfish  1221 LKESALPIKSIKPGLE--------AEVFISHCNSPCSFFVQF---ATDEDDIYSLVEKLNADQSR 1274

  Fly  2206 -KLIDPTTNSNG--VC-YSQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVV--PEVWQLPQEI 2264
             :.||.:....|  || ...:|:.:||..::.  :.::..:|..:|:|||.|:  ..|..|.|..
Zfish  1275 CRNIDSSDIHEGDLVCAMFPDDSSWYRAVVRK--NTNEKIDVEFVDFGNTAVISSKNVCHLGQSF 1337

  Fly  2265 EPIPSLALHCQLSKIPMDVSDEKLEEAFAALLEQHF-----------GELYEITTQPN------- 2311
            ...|..::||.:.|:.:|..|::|...|..:|||:.           |.::|:....|
Zfish  1338 ASFPRYSIHCSVHKLNVDSKDQELAPNFKQVLEQNIEKVICTFVKMSGTMWEVRLDVNGVVLGSV 1402

  Fly  2312 -EDETKPLIA---------ELRI--NYKDFVQELVSTVTGVQKPLEAELHNCVVVQFDGPMSF-- 2362
             :|..||.||         |:::  .||:....:...:||....::            ||..|
Zfish  1403 CKDHVKPEIAIPDLKDAASEIKVCTYYKNPDISIGQVITGYTSYIK------------GPQLFWC 1455

  Fly  2363 -YVQMESDVPALEQMTDKLLDAEQDLPAFSD--LKE-----GALCVAQFPEDEVFYRAQI-RKVL 2418
             ||.|:.    |::::|.|    |::...|:  |:|     |:.|:|.|.||.::|||:: .|.|
Zfish  1456 QYVAMDK----LQEISDML----QNIGNASETTLREDCMPVGSACIALFTEDNLWYRAKVTSKDL 1512

  Fly  2419 DDGKCEVHFIDFGNNAVTQ--QFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTRFSE 2481
            |  ...:.|:|:||.:..:  ..:.||.:|:....::..|:|:...:|       :.|.|....:
Zfish  1513 D--TLSITFVDYGNESKVKIGDVKALPPKLSDVPPHAFDCQLEGFDVS-------EGFWDETADD 1568

  Fly  2482 TFQVEILATKGTG-----------THVVRL 2500
            .| .|::..|...           .|:|:|
Zfish  1569 AF-YELVHDKPLNITIEKMGNSEMPHIVKL 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965
		TUDOR	454..510	CDD:197660
		TUDOR	591..707	CDD:278965
		TUDOR	644..693	CDD:197660
		TUDOR	1012..1132	CDD:278965	27/135 (20%)
		TUDOR	1062..1119	CDD:197660	15/72 (21%)
		TUDOR	1309..1425	CDD:278965	34/118 (29%)
		TUDOR	1354..1411	CDD:197660	21/56 (38%)
		TUDOR	1614..1727	CDD:278965	35/132 (27%)
		TUDOR	1666..1711	CDD:119391	17/47 (36%)
		TUDOR	1791..1906	CDD:278965	35/130 (27%)
		TUDOR	1843..1886	CDD:119391	14/42 (33%)
		TUDOR	1975..2089	CDD:278965	15/116 (13%)
		TUDOR	2028..2069	CDD:119391	0/40 (0%)
		TUDOR	2159..2277	CDD:278965	34/123 (28%)
		TUDOR	2210..2264	CDD:197660	15/58 (26%)
		TUDOR	2345..2458	CDD:278965	33/125 (26%)
		TUDOR	2396..2437	CDD:119391	16/41 (39%)
tdrd6	XP_694024.6	Tudor_SF	6..132	CDD:413384
		Tudor_TDRD6_rpt2	233..361	CDD:410492	29/142 (20%)
		Tudor_SF	482..613	CDD:413384	39/148 (26%)
		Tudor_SF	705..828	CDD:413384	36/141 (26%)
		Tudor_SF	917..1042	CDD:413384	34/129 (26%)
		Tudor_SF	1238..1349	CDD:413384	34/115 (30%)
		Tudor_SF	1440..1579	CDD:413384	42/168 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583656
Domainoid	1	1.000	64	1.000	Domainoid score	I10177
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3771
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232447at33208
OrthoFinder	1	1.000	-	-		FOG0002918
OrthoInspector	1	1.000	-	-		otm24939
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4796
SonicParanoid	1	1.000	-	-		X4998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930