Protein Alignment tud and TDRD1

DIOPT Version :10

• Sequence 1: NP_476773.1
• Gene: tud / 37417
• FlyBaseID: FBgn0003891
• Length: 2515
• Species: Drosophila melanogaster
• Sequence 2: NP_942090.1
• Gene: TDRD1 / 56165
• HGNCID: 11712
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 1279
• Identity: 269/1279 - (21%)
• Similarity: 444/1279 - (34%)
• Gaps: 411/1279 - (32%)

  Fly  1467 ENNQSVIDLLKAEKLVPGKDL----------DYMRKQMEKG-KSRTYEYIETVDLTLDEEEDKGR 1520
            |.|::        ||.|.:.|          ::..|..|.| |...:...|.....|..:||.
Human    29 EKNEN--------KLPPHESLRSPGTLPNHPNFRLKSSENGNKKNNFLLCEQTKQYLASQEDN-- 83

  Fly  1521 KETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPV 1585
                |.|.:.|....:...:..||   |..||.            .:.||..||....||
Human    84 ----SVSSNPNGINGEVVGSKGDR---KKLPAG------------NSVSPPSAESNSPPK----- 124

  Fly  1586 PEVVEVPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHEN- 1649
                || .|.|......|:||                                   |||:|.||
Human   125 ----EV-NIKPGNNVRPAKSK-----------------------------------KLNKLVENS 149

  Fly  1650 LQIVSPSL-----PQLMNV----------VNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGN 1699
            |.|.:|.|     |.|.:.          :..:.|...|                       |.:
Human   150 LSISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCKQTY-----------------------YCS 191

  Fly  1700 TDCVSDATDIKESMWSHIEPFCLPCALPIRPK----------GTADWVDAAN------GIFNESY 1748
            |.|       :...||.....|    .|::|.          .|.| |:..|      |:..|..
Human   192 TAC-------QRRDWSAHSIVC----RPVQPNFHKLENKSSIETKD-VEVNNKSDCPLGVTKEIA 244

  Fly  1749 SKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQ 1813
            ....|:               |:.|...:..|...:......|:...|            ||::|
Human   245 IWAERI---------------MFSDLRSLQLKKTMEIKGTVTEFKHPG------------DFYVQ 282

  Fly  1814 LERDSKALE--------LIELY--LRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQK-ELPD 1867
            | ..|:.||        |.|.|  :.:||.: |:    ||.:..|.:..|:.|.||.:|. ::..
Human   283 L-YSSEVLEYMNQLSASLKETYANVHEKDYI-PV----KGEVCIAKYTVDQTWNRAIIQNVDVQQ 341

  Fly  1868 SRYEVLFIDYGNTS--TTSKCLMLSEEIASLPSLSKKCSLQ--LPDAYISWSPE----------- 1917
            .:..||:|||||..  ..::...|:..|...|..:.||.:.  :| |..:||.:
Human   342 KKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIP-AEGNWSSDCIKATKPLLME 405

  Fly  1918 --AEAKFAELTGEGELVFTTQLLKPGQ----DHVTID----LLLDGENIIDRLLPLCQRKEPKEA 1972
              ...|..::..|..:.|..::..|..    |||.|:    |...|:   |.......:.:|::.
Human   406 QYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQ---DSKKENADQSDPEDV 467

  Fly  1973 SK---ESLAVTTKA-----------------IITHVENTSRIYLQ-------FSEKDSLMDIICE 2010
            .|   |:..|..|:                 ::.|::.....:.|       .:|..:.:...|:
Human   468 GKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCD 532

  Fly  2011 KLNGSKLQPKTE-KAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGN---------TT 2065
                 :|.|::: ..|:.|:|..||::|.::||:.:|....::...|..:||||         ..
Human   533 -----QLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCP 592

  Fly  2066 VVDKLYELPQE-----FTLIKPVAEICSMEPSAIFEK---NKALTLTTFDALLDSCKGVVAVEFV 2122
            ::.||.|||.:     ...:||...|.:.|...:.:|   ||.:|:...|.|.:|.    .||.:
Human   593 IIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSS----LVELI 653

  Fly  2123 NKSASPPVVRLTTKDKRSLKIYEHLQKLVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSA 2187
            :||.:|.|        ...|:.......|..:..:..|.::..|..:..|       |:.|.|..
Human   654 DKSETPHV--------SVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLG-------VEGKVNPL 703

  Fly  2188 D-----------LDLIVKTLQS--------LKKEKLKKLIDPTTN---------SNG-------- 2216
            :           :|::|..:.|        ||::.||||.|...:         .||
Human   704 EWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQP 768

  Fly  2217 -VCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYGN--TLVVPEVWQLPQEIEPIPSLALHCQLSK 2278
             ..:...|..:||..:|.:| |:...:|..:||||  .:...|:..:......:|...:.|||:.
Human   769 CCAFFAGDGSWYRALVKEIL-PNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832

  Fly  2279 I---------------PMDVSDEKLEEAFAALLEQHFG-ELYEITT------------------- 2308
            |               .|.|:..||:.....:.|...| ||.:::|
Human   833 IQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKS 897

  Fly  2309 -QPNEDETKPLIA---ELRINYKDFVQELVSTVTGVQ-KPLEAELHNCV---VVQFDGPMSFYV- 2364
             .|::|.....:.   ||:::    ||.|.:|.:..| |.:|..:...:   |::...|..||.
Human   898 ASPHKDLPNDRLVNKHELQVH----VQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYAL 958

  Fly  2365 --QMESDVPALEQMTDKLLD---AEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCE 2424
              .|..:...|..:|.:||:   |.:..|.:.. :.|..|.|::..|:.:|||.:... .|...|
Human   959 PKGMPENQEKLCMLTAELLEYCNAPKSRPPYRP-RIGDACCAKYTSDDFWYRAVVLGT-SDTDVE 1021

  Fly  2425 VHFIDFGNNAVTQQFRQLP---EELAKPARYSRHCELDA-----STISKCDAALLQSFI------ 2475
            |.:.|:||.......|..|   ..||.|.:..| |.|:.     .:.|:....||::|:
Human  1022 VLYADYGNIETLPLCRVQPITSSHLALPFQIIR-CSLEGLMELNGSSSQLIIMLLKNFMLNQNVM 1085

  Fly  2476 -----DTRFSETFQVEILATKGTGTHVVRL--FYQSKNISEKLQ 2512
                 .|:...|..||..:..||.....:|  |..:|||:.:.|
Human  1086 LSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQ 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	TUDOR	411..524	CDD:425754
		TUDOR	595..707	CDD:425754
		TUDOR	1016..1132	CDD:425754
		TUDOR	1309..1425	CDD:425754
		TUDOR	1620..1727	CDD:425754	20/122 (16%)
		TUDOR	1795..1906	CDD:425754	34/123 (28%)
		TUDOR	1980..2089	CDD:425754	29/147 (20%)
		TUDOR	2163..2277	CDD:425754	32/152 (21%)
		TUDOR	2347..2458	CDD:425754	31/122 (25%)
TDRD1	NP_942090.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..138		20/89 (22%)
		zf-MYND	170..206	CDD:460312	7/65 (11%)
		Tudor_TDRD1_rpt1	268..396	CDD:410479	39/146 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..469		3/21 (14%)
		Tudor_TDRD1_rpt2	517..598	CDD:410480	19/85 (22%)
		TUDOR	715..832	CDD:425754	28/117 (24%)
		Tudor_TDRD1_rpt4	944..1059	CDD:410482	32/117 (27%)