DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and tdrd1

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	1195	Identity:	236/1195 - (19%)
Similarity:	401/1195 - (33%)	Gaps:	377/1195 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1299 SFICPYPVV-----LSSFQALVVYTAKP--YRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKF 1356
            |.:| ||.:     ....|..|:....|  :.::.|.:.::.|::.:...:.:.|.:......|.
Zfish   185 SLVC-YPSIDTLPHTKCLQGTVIDLRNPGMFSIHCQCEEMIESLKKITQQLQKTYCSSFAQEYKP 248

  Fly  1357 DVGQICAVR-SSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAV 1420
            :||::|||: |.|.|||||.|...|.......|||||:||.|.:..|.|:.|.... :....||:
Zfish   249 EVGELCAVKFSLDQNWYRAEIQAVDVARKTAGVFYIDFGNEENVALDHIRPLSENI-DAVPPFAL 312

  Fly  1421 EINLPIGRPSNDT---KLKARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLV 1482
            :..:...:|...:   :....:.:::..|.:|...:::....              |||..:.||
Zfish   313 QCCIAGVKPLTGSWTGECCIAVRQLIAGKSLTFTVLDIMNDG--------------DLLAVDSLV 363

  Fly  1483 P--GK-------DLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQ 1538
            .  ||       |..|..|:....|::|...|.:: ||...|..|      ..||..|
Zfish   364 STLGKHVSTFLIDQSYAIKEDVPVKTQTEHSINSL-LTASFENFK------RFSGGKN------- 414

  Fly  1539 HNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEVPEINPTVREAAA 1603
                  |..:::|.||                                           :.:...
Zfish   415 ------ENSEARPPEP-------------------------------------------LTQGVG 430

  Fly  1604 ESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQI--VSPSLPQLMNVVNG 1666
            :|..|             |::|..:|::.....::..|.:.||..||::  .:.:.........|
Zfish   431 DSFTA-------------VVTHLQSPSEILCQKLENASIIQQLQMNLRVHCSNTAASDDFRPAPG 482

  Fly  1667 ADCVSMYSVDKCWYRAKII---DAELMVLLFIDYGNTDCVSDATDIKESMWSHIEPF-------- 1720
            ..|.|::|.|..|||||::   ..:.:.:.:||:||::         |...:.:.|.
Zfish   483 TVCCSLFSEDNQWYRAKVLAYSSEDRVCVGYIDFGNSE---------EVELNRLRPISKELLALA 538

  Fly  1721 --CLPCALPIRPKGTADWVDAANGIFNESY-SKVPRLEYLTQGDHYTTSYVNMYIDGED----VA 1778
              .:||:|......|..|.|.|..:..... ::..|:|.|.:.|  ..:.|:|..:..|    |.
Zfish   539 TQAIPCSLAGIKSLTDTWSDEAVLMLKHLVCNRFIRVEILGKKD--GRALVSMIDESSDPQASVT 601

  Fly  1779 KKLIADGFA----------------------------RPLEYLASGCSCYISHVNGICDFFIQLE 1815
            :.|:..|||                            ..||:..:                 :|.
Zfish   602 ELLVNMGFAAIESVETKKNEPDPATSTEIPPLSQPVVEKLEWTGA-----------------ELP 649

  Fly  1816 RDSKALELIELYLRKKDTLKPLEGF--------------------------EK-------GLIVA 1847
            .|.:.:||:      ..|||.|:.|                          |:       |....
Zfish   650 FDGQKVELV------ISTLKSLDEFYCYNYSKTDEHTLTEMSFELMKHCESERAPFTPIVGEPCC 708

  Fly  1848 ALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLM--LSEEIASLPSLSKKCSLQ-LPD 1909
            |||..|..||||.:.:...:.:..|.|:||||:.......:  :::.:..||..:.:|.|. :..
Zfish   709 ALFTGDARWYRAMVLEVCGEGKARVCFVDYGNSCEVDAAHLKAITQSLLKLPFQAIRCWLAGVEP 773

  Fly  1910 AYISWSPEAEAKFAELTG----EGELVFTT------QLLKPGQDHVTIDLLLDGENIIDRLLPLC 1964
            ....|..||..:|..|..    .|:::..|      :|...||   |:..:|..|::..   |..
Zfish   774 VEGQWKKEAMLRFQALCAGQPLSGKVLSITEKGYGMELESAGQ---TVASVLISEHLAK---PYG 832

  Fly  1965 QRKEP------KEAS-----------------KESLAVTTKAIITHVENTSRIYLQFSEKDSLMD 2006
            |.::|      |.||                 :|.|.|::|...|..|:.......|......::
Zfish   833 QVRQPPQIQPAKPASQIEDLPSLKPIDQNPSVEEPLKVSSKGAATTPEDLPVSSGCFPLNWKTLE 897

  Fly  2007 IICEK-----------------LNGSKLQPKTEKAAVDDM--------------------CVVQF 2034
            :.|..                 :|..::..:..||.:.|:                    |..||
Zfish   898 LSCSGTFQPRVAAVISPSLFYIMNPGQVNVEGLKAVMTDVAKYCSKQPVPNQCHPLPGASCCAQF 962

  Fly  2035 ADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEI--CSME------- 2090
            :.|..:||:.:|||.....: ||..||||...|.....||....|::...:|  |::.
Zfish   963 SGDKNWYRAVVLEVTTKHAH-VIYSDYGNMETVPLSSILPITKELLQHPFQIVRCALTGKEHFPV 1026

  Fly  2091 --PSAIFEKNKALTLTTFDALLDSCKGVVAVEFVNKSASPPVVRLTTKDKRSLK-----IYEHLQ 2148
              |:.:.|        .|...|   .|.|...|.....:..::.||.:..:|.:     |...||
Zfish  1027 VWPTEVLE--------LFGIQL---SGGVLASFQGFDGTSNLLTLTQQSGQSDRDINSIILGALQ 1080

  Fly  2149 K-LVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTT 2212
            | .::...||....||..:.:......|      :..|.|       ..|:|.....|..:|..|
Zfish  1081 KGQIKPSSKLPANVNEEKKDVEQKQTQP------ISSNKA-------VEQTLSTNVEKPALDDQT 1132

  Fly  2213 NSNGVCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVVPEVWQLPQEIEPIPS----LALH 2273
            ....|....|             :|.        :...|....|....|..:..|.|    .:..
Zfish  1133 LPLSVSLKHE-------------EPE--------NMSKTKTAEECTSTPDTVSSIESSHAAQSCC 1176

  Fly  2274 CQLSKIPMDVSDEKLEEAFAALLEQ 2298
            ||..|..||    ::||....|::|
Zfish  1177 CQELKQKMD----RIEELVLLLVKQ 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965
		TUDOR	454..510	CDD:197660
		TUDOR	591..707	CDD:278965
		TUDOR	644..693	CDD:197660
		TUDOR	1012..1132	CDD:278965
		TUDOR	1062..1119	CDD:197660
		TUDOR	1309..1425	CDD:278965	34/118 (29%)
		TUDOR	1354..1411	CDD:197660	26/57 (46%)
		TUDOR	1614..1727	CDD:278965	26/127 (20%)
		TUDOR	1666..1711	CDD:119391	14/47 (30%)
		TUDOR	1791..1906	CDD:278965	29/149 (19%)
		TUDOR	1843..1886	CDD:119391	15/42 (36%)
		TUDOR	1975..2089	CDD:278965	33/152 (22%)
		TUDOR	2028..2069	CDD:119391	17/60 (28%)
		TUDOR	2159..2277	CDD:278965	20/121 (17%)
		TUDOR	2210..2264	CDD:197660	7/53 (13%)
		TUDOR	2345..2458	CDD:278965
		TUDOR	2396..2437	CDD:119391
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734
		TUDOR	210..318	CDD:306940	32/108 (30%)
		TUDOR	429..548	CDD:306940	29/140 (21%)
		TUDOR	652..770	CDD:306940	27/123 (22%)
		TUDOR	908..1020	CDD:306940	25/112 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11028
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24939
orthoMCL	1	0.900	-	-		OOG6_107416
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810