DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and krimp

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	181/910 - (19%)
Similarity:	287/910 - (31%)	Gaps:	330/910 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 ESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNTRAESV 792
            :||:.:...::|.::.|...::  ..|.:.|:....||:..:|...:|.....:.||:
  Fly    14 DSNMHKLQGNLRSYQTEMHQIH--KELTEKLSHADLLYRSLIPLHDHLVASLSEVNAH------- 69

  Fly   793 ISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVD-----VRQQQLAVEIPQAVKSV-SGSKNS 851
             ..:||....:|..|:     ||.:.  |..:|.:|     :|....|:|.|...::: ..||.:
  Fly    70 -VMKLNVQLHINRQSV-----RLGDY--EYYEKSIDNPYSSIRSGLQAIEKPGCAEAICQSSKPA 126

  Fly   852 TDWDKRSSTS------AGSKDSKRQQQQQIQRIDRHLDFSCETQSTG---SYSSGMSSPRKGN-- 905
            ......||||      |..:.|...|...|..::.:|  |.|..:|.   :.|..|......|
  Fly   127 FVECLPSSTSEEVPVVAVQEASSTNQLDAISVVNENL--SEERDATPQPLAVSKNMEETMPSNPF 189

  Fly   906 -RQQNG---RTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQ---GNQRSQNAPQGYAQKPQR 963
             .|..|   ..|:.|....|.::|....| |.:.:|..| |.|.   ..|.:|....|...|
  Fly   190 HEQLEGSLEEIPVGSKIVVETEKANNPVR-SEASAPATS-DNQSLLAAKQGTQTIGTGICNK--- 249

  Fly   964 QKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSP 1028
                     .||.:..:.::....:...|.||..||...|.|                     ||
  Fly   250 ---------ISKSTINMPNNWQLENPTEVTAASIEKVNKLPK---------------------SP 284

  Fly  1029 FQFYIVPKSVSAK------YDNIMRDMREF--------------------YRQK----------- 1056
            ...:::|.....:      |:.|::||..|                    |..|
  Fly   285 RNRFLLPPKGGTETTRRDIYNQILKDMAAFPENTIVTAVLASVDVTDNCAYVAKWDESSDRIKKV 349

  Fly  1057 -QHQ-PLQ-----LKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDTGSLITVT-SEDIW 1113
             |.| |||     ...|....|....:|.|.|.|:.: :.....|..:.:|.|..|... :|.|:
  Fly   350 LQRQLPLQELDQLPDYGDIFAVLDSINNIITRITINS-SSAGGGYDAYLIDFGEHIHFDGNETIF 413

  Fly  1114 QLEQRFADPPCMAHRC--------SFHSVVTNY---------------DPLYIVDRMETFVPVNA 1155
            :|.......|..|.||        :.|..|..|               :|  ::||:......|.
  Fly   414 KLPDDIKRLPAQAIRCDLINCDIANMHCFVNTYIKIRVHENNNSTLVAEP--VIDRLSRPTKTNT 476

  Fly  1156 --------------------------KVDCEFVSKEKSN---------QGSNTSSTCSYTVNIFV 1185
                                      |....|..|::..         .|....:.|.:....|.
  Fly   477 TKYPAGITEDDMAMLNEIDESTSDPLKAVLGFRPKDEQRICRHYDPKLNGCFKGNNCRFAHEPFA 541

  Fly  1186 -NGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDD- 1248
             |||:      |...|....||                :|.|.|   |.|:.|:.|..|.|:.:
  Fly   542 PNGAT------KDVELARALPE----------------TIFDTT---VHFEIGSIVGILITFING 581

  Fly  1249 -----AKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVL 1308
                 .:|:..:|.|             ..:.|:|.||               :|:|
  Fly   582 PTEVYGQFLDGSPPL-------------VWDKKDVPEN---------------KRTF-------- 610

  Fly  1309 SSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYR 1373
                     .:||               .|||.:...|                    |||.:||
  Fly   611 ---------KSKP---------------RLLDIVLALY--------------------SDGCFYR 631

  Fly  1374 ARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALD--AKFYEH-ASGFAVEINLPIGRPSNDTKL 1435
            |:|.  |...:.:.:||:||||||.:....:...:  ..|..| ...|.:|   .|.|..|.|..
  Fly   632 AQII--DEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFHIE---GIVRSKNLTHQ 691

  Fly  1436 KARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPG------KDLDYMRKQM 1494
            |            ||:.||..:|.|:      |.:..:.|:  ::|..|      .|..|:.:|:
  Fly   692 K------------TIECIEYLKSKLL------NTEMNVHLV--QRLPDGFLIRFLDDWKYIPEQL 736

Fly 1495 1494
Fly 737 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965
		TUDOR	454..510	CDD:197660
		TUDOR	591..707	CDD:278965
		TUDOR	644..693	CDD:197660
		TUDOR	1012..1132	CDD:278965	32/172 (19%)
		TUDOR	1062..1119	CDD:197660	14/62 (23%)
		TUDOR	1309..1425	CDD:278965	26/118 (22%)
		TUDOR	1354..1411	CDD:197660	16/58 (28%)
		TUDOR	1614..1727	CDD:278965
		TUDOR	1666..1711	CDD:119391
		TUDOR	1791..1906	CDD:278965
		TUDOR	1843..1886	CDD:119391
		TUDOR	1975..2089	CDD:278965
		TUDOR	2028..2069	CDD:119391
		TUDOR	2159..2277	CDD:278965
		TUDOR	2210..2264	CDD:197660
		TUDOR	2345..2458	CDD:278965
		TUDOR	2396..2437	CDD:119391
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	38/192 (20%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000