Protein Alignment tud and Tdrd6

DIOPT Version :10

• Sequence 1: NP_476773.1
• Gene: tud / 37417
• FlyBaseID: FBgn0003891
• Length: 2515
• Species: Drosophila melanogaster
• Sequence 2: NP_001419573.1
• Gene: Tdrd6 / 316254
• RGDID: 1305956
• Length: 2129
• Species: Rattus norvegicus
• Alignment Length: 2359
• Identity: 462/2359 - (19%)
• Similarity: 792/2359 - (33%)
• Gaps: 800/2359 - (33%)

  Fly   406 LTVGLTYDVVISYVENGPYLFWVHLKSSD---HDLSTMMGQIERTKL------------KALAQA 455
            |.:|:|..||::.|.: |:.....|:|..   |.||..|.|:.|...            :...::
  Rat   245 LQLGVTEPVVVTQVCH-PHRIHCQLRSLSQEIHRLSESMAQVYRAPTGTEDEDSGSATWEEREES 308

  Fly   456 PEL-GTACVARFSEDGHLYRAMVCAVY-AQR-YRVVYVDYGNSELLSASDLFQIPPELLEIKPFA 517
            |:. |:.| |....||..|||::...: .|| .:|::||||..||:|.|.|..:.||...:....
  Rat   309 PDKPGSPC-ASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVT 372

  Fly   518 FRFALAGTKEI------EPIDDSMKRIFKKSAI------YRNFE----LTVQAPESVG-----SM 561
            :..||.|..:.      ..:.| :|.:....|:      |.:||    :|:...:.:.     .:
  Rat   373 YPCALYGLWDCGRGWSRSQVGD-LKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGV 436

  Fly   562 QTC-----HLNQNGTNML--ELLRQLKNSRQSYKKAEQLEND-----------------DAVEIR 602
            |:|     .|...|....  |...:::.:.||...||::|.:                 || ::.
  Rat   437 QSCCLADRFLQSQGIEEEEDEDEDEMEAAFQSQSPAEEMEEEVSLPSLRSIRLKMNTFYDA-QVE 500

  Fly   603 FIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRV--------PDQLILGAPCIVKCDQE-WYR 658
            |:.|||.|:::...:...|.:|...|.|:|::..::        ||.|     |.||..:. :||
  Rat   501 FVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILKPEPDDL-----CCVKWKENGYYR 560

  Fly   659 AEILRVDD-SVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKITDQF 722
            |.:.|:|. ||.|..||.|..:||....:..:..:..::|..|:||.|             .|.:
  Rat   561 AMVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTL-------------ADIW 612

  Fly   723 EMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNT 787
            .:        .:|:|                                  ::.:|..|
  Rat   613 PL--------GKTWS----------------------------------QEAISFFK-------- 627

  Fly   788 RAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNST 852
              ::|:..|| ..|||                        |.:.:|..:||
  Rat   628 --KTVLHKEL-VVHIL------------------------DKQDRQYVIEI-------------- 651

  Fly   853 DWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSP 917
                        .|..|..::.|.::              ...:|.:..::...::|.|....||
  Rat   652 ------------LDESRTGEENISKV--------------IAQAGYAKFQEFETKENIRLSAHSP 690

  Fly   918 RHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGS 982
            .|       .:..|....|...|....:|:|:::|..:..:. |:...:....|||:.:::....
  Rat   691 GH-------VSGHFIAESSKIPSVKKVEGDQKAKNDNKTLSD-PEALATVSLSNISTGQTAQDKE 747

  Fly   983 DIASSSS---ESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAKYDN 1044
            .:.|..:   .::...||:       .....|::..|.....:|...:|..|:......:..:..
  Rat   748 KVTSDPTLLMLNLLKTKPD-------CCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRT 805

  Fly  1045 IMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDTGSLITVTS 1109
            :|.|:.::.:.   :|...:..:...:.:|..|......:.:....:...||..||.|....|:.
  Rat   806 LMCDIEDYCKS---EPSPYEGDTRACLAKRTANGRWSRALISGAQSLEHVRVVFVDYGDKDVVSM 867

  Fly  1110 EDIWQLEQRFADPPCMAHRCSFHSVV--TNYDPLYIVDR-METFVPV-------NAKVDCEFVSK 1164
            :||..:...|......|.|||.::::  |..:|....:| ::.|...       |.::.|...:
  Rat   868 KDILSVSDVFFKVRAQAFRCSLYNLIQPTGENPFVWDERAIQAFTGFIDNAWQNNLELKCTIFA- 931

  Fly  1165 EKSNQGSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTS 1229
                ..|.....|...|::.....|....||:......|  :::..|....|:...:.|..|:..
  Rat   932 ----LASRHEEECFNVVDLLTPFQSACHFLVEKRLARPV--KLQKPLEPSVQLHSYYYSTHDLKI 990

  Fly  1230 FKVQFDYGNNVN----FLCTYDDAKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVM 1290
            ...:..|..:.:    |.|            .|||.              .|:.|....|:..:.
  Rat   991 GSEELVYITHADDPWTFYC------------QLARN--------------TNILEQLSYHIMQLS 1029

  Fly  1291 PLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKK 1355
            .:.:..|.|.:.|
  Rat  1030 KVLLNLRTSTLVP---------------------------------------------------- 1042

  Fly  1356 FDVGQICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAV 1420
               |.:|..:.:||||||..|..|:.:    :||::|:||| .:..|.:
  Rat  1043 ---GTLCLAKYTDGNWYRGIIIEKEPS----KVFFVDFGNT-YVASDHL---------------- 1083

  Fly  1421 EINLPIGRPSNDTKL------KARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVID-LLKA 1478
               |||.|.:.|..|      |..:|:|              ..|:..:|.....::|:| .|||
  Rat  1084 ---LPIPRDAYDVLLLPMQAVKCSLSDI--------------PHHIPEEVTAWFQETVLDKSLKA 1131

  Fly  1479 EKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHND-- 1541
              ||..||.|        |:.....|.|:|.:.....|..|      ..|..|.:.:|.:.|:
  Rat  1132 --LVVAKDPD--------GRLIIELYDESVQINASINEKLG------LLGYKNRTRRKDKENEII 1180

  Fly  1542 -KDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEV------PEINPTVR 1599
             ::.|..:.| ||           :..|||...    :.|........||:      |:::|..:
  Rat  1181 LRETETLQDK-AE-----------IMKPSPTDY----LGKSGDSKAHGVEIMGESCKPKLSPACK 1229

  Fly  1600 EAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVV 1664
            |                                    :..|....:.|    :|:|....:.|..
  Rat  1230 E------------------------------------LKYLQGSGKAH----LVTPYQDSMGNKN 1254

  Fly  1665 NGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDIKESMW--SHIEPFCLPCALP 1727
            :|...::         |.|                          :|.|:  |.:....|..|||
  Rat  1255 DGGFLLT---------REK--------------------------REDMFASSPMSATKLESALP 1284

  Fly  1728 IRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPLEY 1792
            .|..|.|...|     ....:.:.|                          :|.||.||.
  Rat  1285 ERRMGEASGKD-----LPPKFCEFP--------------------------QKTIAPGFK----- 1313

  Fly  1793 LASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKD--------TLKPLEGFEKGLIVAAL 1849
                .|.|:||:|.:.||:|||..|.  .|:..|..|..|        |..|   ::.|.::.|:
  Rat  1314 ----TSVYVSHINDLSDFYIQLIEDE--TEINRLSERLNDVRTRPQYHTGPP---WQSGDVICAV 1369

  Fly  1850 FEDDELWYRAQLQKELPDSRYEVLFIDYGNTST--TSKCLMLSEEIASLPSLSKKCSLQ---LPD 1909
            |.:|.|||||.:.::..:....|.||||||.|.  |::...|....|.||:|...|||:   :||
  Rat  1370 FPEDNLWYRAVVLEQQHNDLLSVQFIDYGNMSVVHTNRTGRLGPIDAVLPALCLHCSLRGIVVPD 1434

  Fly  1910 --------AYISW-SPEAE--AKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENIIDRL--- 1960
                    ||.|. :.||:  .:|.:..|..|::.       ..:|..|     .|:||:|.
  Rat  1435 IVGTKEMVAYFSQRTDEAQIRCEFVKFQGTWEVIL-------ADEHGII-----AEDIINRFPFN 1487

  Fly  1961 ----LPLCQRKEPKEASKESLAVT----------------TKAIITHVENTSRIYLQFSEKDSLM 2005
                ..|..:....:.||.:|...                .||..|.::.....:.||::.:.|.
  Rat  1488 GKSQAGLTTQSMKGDCSKTALKTNMDTSVFLNWYNPKMKLIKAYATVIDGPEYFWCQFADSEKLQ 1552

  Fly  2006 DIICEKLNGSK----LQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNT-T 2065
            .:..|..|.:|    .:..|:...:.|.|:|::.:|..:||:.|..:.:|....|.|:|:||. .
  Rat  1553 YVETEVQNAAKQLADRKSCTQCPQIGDPCIVRYREDGHYYRALITNICDDHLASVRLVDFGNVED 1617

  Fly  2066 VVD--KLYELPQEFTLIKPVA------------EICSMEPSAIF---EKNKALTLTTFDALLDSC 2113
            .||  .|:.:|.|..|:...|            .:|..|.:..|   .....|.:|..:...|.|
  Rat  1618 CVDTNALWSIPSELLLVPMQAFPCCLSGFTVSGGVCPQEGNDYFYDIVTEDVLEITILEIKRDVC 1682

  Fly  2114 KGVVAV-------EFVN-------KSASPPVVRLTTK----------------DKRSLKIYEHLQ 2148
            ...:||       |.:|       |:.:|.....:.|                .|.|.||.:...
  Rat  1683 DIPLAVVELRSKGENINEKMKKYAKTGTPKSGLYSEKHGAERKGGLSSPDLGLKKPSHKIAQEKT 1747

  Fly  2149 KLVQAELKLIQKRNE---NSECIIS--YGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLI 2208
            ..::|....:.:|.|   |.|...|  |..||::.:...:|:...         .:..::|:
  Rat  1748 FYMEARASELSERFEKDLNIETRPSKFYERSPRNIFNAFEHSCQG---------KMGSQRLE--- 1800

  Fly  2209 DPTTNSNGVCYS-----QEDACYYRCSIKSVL----DPSQGFEVFLLDYGNTLVVP--------E 2256
                  .|:.|.     :.|..|.......:|    :|.:..|:      |:|.||        |
  Rat  1801 ------GGMDYHFVDRVKYDDTYLMTGFNPILAHASEPKELLEL------NSLEVPLSPDDECKE 1853

  Fly  2257 VWQL--------------PQEI---EPIPSLALHCQ--------LSKIPMDVSDEKLEEAFAALL 2296
            ..:|              .:|:   .|:..|:..||        :.::|:|...||..|
  Rat  1854 FLELESIDLQHSPAGEEDKEELGLGSPMAPLSPGCQAGATLEPFMVQLPLDCEAEKQLE------ 1912

  Fly  2297 EQHFGELYEITTQPN---EDETKPLIAELRINYKDFVQELVSTVTGVQKPLEAELHNCVVVQFD- 2357
                   .|:.| |.   ||...||.|.:..|..:            .:..|.|..:..|...|
  Rat  1913 -------LELPT-PQLSLEDSISPLSATVSQNMPE------------SRSAEDERKSSCVGSSDD 1957

  Fly  2358 ------GPMSFYVQMESDVPALEQMTDKLLDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRK 2416
                  .|:..:.: ..|.||.::|.    .:|::.|.|.:....||....|.|:|.  |.. ||
  Rat  1958 DDDHSASPLPHHGK-GGDSPAHDEMN----LSEEEFPQFENRDSAALLAPLFSEEEA--RGG-RK 2014

  Fly  2417 VLDDGKCEVHFIDFGNNAVTQQFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTRFSE 2481
                |:.||..::..|....:.|                     |..|||   ::.|.:...:|
  Rat  2015 ----GRSEVPAVELQNTYTLKGF---------------------SVGSKC---VVWSSLRNTWS- 2050

  Fly  2482 TFQVEILATKGTGTHVVRL 2500
              :.||||....||.|:.|
  Rat  2051 --KCEILALAEEGTRVLNL 2067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	TUDOR	411..524	CDD:425754	38/130 (29%)
		TUDOR	595..707	CDD:425754	36/138 (26%)
		TUDOR	1016..1132	CDD:425754	22/115 (19%)
		TUDOR	1309..1425	CDD:425754	17/115 (15%)
		TUDOR	1620..1727	CDD:425754	13/108 (12%)
		TUDOR	1795..1906	CDD:425754	42/120 (35%)
		TUDOR	1980..2089	CDD:425754	31/143 (22%)
		TUDOR	2163..2277	CDD:425754	27/160 (17%)
		TUDOR	2347..2458	CDD:425754	24/117 (21%)
Tdrd6	NP_001419573.1	Tudor_TDRD6_rpt1	6..136	CDD:410491
		Tudor_TDRD6_rpt2	239..379	CDD:410492	40/135 (30%)
		Tudor_SF	494..628	CDD:470623	41/204 (20%)
		Tudor_SF	773..892	CDD:470623	22/121 (18%)
		Tudor_SF	981..1105	CDD:470623	38/228 (17%)
		Tudor_SF	1313..1427	CDD:470623	41/127 (32%)
		Tudor_SF	1528..1670	CDD:470623	33/141 (23%)