DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and Rnf17

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	NP_001028215.1	Gene:	Rnf17 / 30054	MGIID:	1353419	Length:	1640	Species:	Mus musculus

Alignment Length:	1865	Identity:	348/1865 - (18%)
Similarity:	609/1865 - (32%)	Gaps:	700/1865 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 SDLFQIPPELLEIKPFAFRFALAGTKEIE-PIDDSMKRIFKKSAIYRNFELTVQAPESVGSMQTC 564
            |.|..:||:::.          ..:.::| .:|..:..:...|:|:||    |..|.:|.| :|.
Mouse    95 SSLEALPPKMVN----------NCSSDLEKTVDQLINDLEHSSSIHRN----VSNPSAVMS-ETE 144

  Fly   565 HLNQ----NGTNMLELLRQLK--NSRQSYKKAEQLENDDAVEIRF------IDS----------- 606
            .:::    .|.|..:|...:|  :|.|...:.|.....:|||.:|      :||
Mouse   145 EIDEALKIAGCNFEQLSNAIKMLDSTQDQTRQETHSLTEAVEKQFDTLLASLDSRKKSLCEELIR 209

  Fly   607 PSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCI-VKCDQEWYRAEILRVDDSVIV 670
            .::.|:.|:..:..:   ::|..|..:|..::..:| ..||.: ..||.            :.|:
Mouse   210 RTDDYLSKLVTVKSY---IEEKKSDLDAAMKIAKEL-RSAPSLRTYCDL------------TQII 258

  Fly   671 RHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKC----CLKGFENSELSEDKITDQFEMLAEESNI 731
            |.:...:|..:.:  :..|..::  .||..|.|    |:    .|.:.:.:..|..:...:|:.
Mouse   259 RTLKLTFESELSQ--VSSIIPRN--TPRLDINCSEAICM----FSSMGKIEFEDSTKCYPQENE- 314

  Fly   732 RRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNTRAESVISSE 796
                          ||.||    .|..|..|:|.     .:.|.||||.:.:|      :|::.|
Mouse   315 --------------DGQNV----QKKFNNRKELC-----CDVYSSLEKKKVDA------AVLTDE 350

  Fly   797 LNKSHILNSTSIGETENRLQEQEKEQQQKK-VDVRQQQLAVEIPQAVKSVSGSKNSTDWDKRSST 860
            ..:..:.     .|..:|..|.:|:|..|: |.|...:....:||.     ||......:
Mouse   351 TPEPPLQ-----AEAPDRHLEGKKKQPTKEMVVVTSPKTIAVLPQL-----GSSPDVIIE----- 400

  Fly   861 SAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSPRHNEKQEA 925
                           :.|:.:|: ||.|..                      ||::
Mouse   401 ---------------EIIEENLE-SCFTDD----------------------PIET--------- 418

  Fly   926 KKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSE 990
                                         .||.:||.::          ::|:.|||
Mouse   419 -----------------------------SGYPKKPPQK----------EQSAPVGS-------- 436

  Fly   991 SVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAKYDNIM------RDM 1049
                                  |....|...:|..:.|..||:      .||..|.      :.|
Mouse   437 ----------------------KAGCPELVFVSHVIHPCHFYV------RKYSQIKDATILEKKM 473

  Fly  1050 REFYRQKQH-QPLQ-LKVGSTVVVRQRKDNAILRATVT----ACNHMMRK--------------Y 1094
            ::...:..| .|.. |::|:.:.|...|:....|..:|    :....:||              .
Mouse   474 KQVCNRSLHLDPSDILELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLI 538

  Fly  1095 RVFCVDTGS----LIT----------------VTSEDIWQL--------EQRFADPPCMAHRCSF 1131
            ::|.||.|:    :||                :|..|...|        |:...|.|.:||.||
Mouse   539 QIFMVDFGNSEVLIITGVGDTHEGPEHDGEQHITLSDFCLLLMKSEPYSEELLKDIPHLAHLCS- 602

  Fly  1132 HSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQGSNTSSTCSYTVNIFVNGASLRDMLVK 1196
                           ::..||.|:....|   ||                             .|
Mouse   603 ---------------LKDIVPYNSTEGWE---KE-----------------------------AK 620

  Fly  1197 AEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDDAKFVKSNPNLARR 1261
            .|||..|..:..:..:.|::.......::...:.|:..|.                   |...|.
Mouse   621 VEFLKMVNKKAVLMKVFGEEDDVLIVDLQKPPTNKISSDM-------------------PVSLRD 666

  Fly  1262 FKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVL----SSFQALVVYTAKPY 1322
            ...|.|               :...|...|....::.:.:|.:|.:|    :....:|.:...|.
Mouse   667 ALVFME---------------LARFRSQSPRSHSEKNTTLCYHPPILPEEMTEVSVMVCHINSPT 716

  Fly  1323 RVYVQPQAIVPSMQ--TLLDNMYEHYKAKGDSLKKFDV-----GQICAVRSSDGNWYRARISGKD 1380
            ..|:|   ::.::.  :||..:.|.|  ||:..:..::     .|.|..:..||.||||::.|..
Mouse   717 DFYLQ---LMENLDFLSLLKTIEEFY--KGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLP 776

  Fly  1381 SNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRPSNDT----KLKARISE 1441
            .:.. .||.|:|:|||.:|...|::.:..:|.|.... |::..|....||..:    |.|.:..|
Mouse   777 GHRE-VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEK-AIKCKLAYVEPSKKSQWSKKAKEKFEE 839

  Fly  1442 ILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIE 1506
            ..::|.||...|:          |||||..:::|.  :...|||....:..|:.|....:||...
Mouse   840 KTQDKFVTCSVIK----------ILENNVLLVELF--DSRAPGKSAVSINDQLVKEGLASYEAGY 892

  Fly  1507 TVDLTLDEEEDKGRKETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPV 1571
            |:                                 ||...|..:..:|:
Mouse   893 TL---------------------------------KDNSKKHLEVWDPS---------------- 908

  Fly  1572 PAEPAPVPKPATPVPEVVEVPEIN----------PTVREAAAESKQAPAQEDPYKDLDCVVLSHC 1626
                          ||.:...|||          |.....:..:|:.|..       .|.|:|
Mouse   909 --------------PEEIITSEINNLSPLSVKSLPNENFQSLYNKELPVN-------ICNVIS-- 950

  Fly  1627 DNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVVNGAD--CVSMYSVDKCWYRAKI---ID 1686
              |.:.||..:...:.||.|.|.: :.:....:...|....|  |.........|.|.:|   :.
Mouse   951 --PEKIYVQWLLTENLLNSLEEKM-VAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVT 1012

  Fly  1687 AELMVLLFIDYG-----NTDCVSDATDIKESMWSHIEPFCLPCAL-PIRPKGTAD---------- 1735
            .:|:.:|..|.|     |..|:.:..:..::|..    ..|.|:| .|||.|.:|
Mouse  1013 DKLVEVLLYDVGVELVVNIHCLRELQENLKTMGR----LSLECSLVDIRPTGGSDKWTATACDCL 1073

  Fly  1736 -------------------W---------------VDAANGIF--------------NESYSKVP 1752
                               |               ||.:..:.              :.|:|...
Mouse  1074 SLHLTGAIATIILQESNTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRERRVSKSSNSHSPEK 1138

  Fly  1753 RLEY-LTQGDHYTTSYVNMYID-GEDVAKKL----IADGFARPLEYLASGC---------SCYIS 1802
            .||. |.|||...|....:..| .:.:|.|:    :.|...:..|..::||         |.:.:
Mouse  1139 SLEIPLEQGDSVVTKCFKINFDTNKKIADKVNEHKVPDSKGKKSESRSTGCYRPPAVPNTSSFEA 1203

  Fly  1803 HVNGICD---FFI--------------QLERDSKALELIELYLRKKDTLKPLEGFEKGLIVAALF 1850
            .|..|.|   .|:              :::.:.|.|.|:|.|..||.....:.|
Mouse  1204 IVTCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRG----------- 1257

  Fly  1851 EDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKC----LMLSEEIASLPSLSKKCSL--QLPD 1909
             .|.||||.::. |:......|.::|:|.|....:|    ::|..:   .|.....|.|  .||.
Mouse  1258 -SDTLWYRGKVM-EVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPD---TPQFCIPCQLYQTLPV 1317

  Fly  1910 AYISWSPEAEAKFAELTGEGEL-VFTTQLLKPGQDHVTIDLLLDG------------------EN 1955
            .. :|.|:|.....||..:.|: :...:|.......:::.|..||                  |.
Mouse  1318 GN-TWQPDAIELLQELLSKREVDIHIMELPNNSWGKLSVHLYFDGMSLSHFMAHHKYCIFEHTEE 1381

  Fly  1956 II---------------------DRLLP----------LCQRKEPKEASKESLAVTTKAIITHVE 1989
            |.                     |.|||          |.....|.|   |..||..|.|::..|
Mouse  1382 IFKEKPRGQNKKYEDENWKIRFEDLLLPEMEAPVLPPYLSSLLPPPE---ELFAVQVKHIVSPDE 1443

  Fly  1990 -----NTSRIYLQF--------------SEKDSLMDIICEKLNGS--KLQPKTEKAAVDDMCVVQ 2033
                 ::...|.||              ||.::|.:.: ::.|.:  ...|.|:.:: :..|:.:
Mouse  1444 MYICLDSEDSYTQFNHHGDTDDSGVSWESESENLEEAL-QRFNKNVETFPPLTDFSS-EMPCLAE 1506

  Fly  2034 FADDLEFYRSRILEVLEDDQYKVIL--IDYGNT--TVVDKLYELP 2074
            :||.| :||::|:.:.|.:...|::  :|||.|  ..:::|.::|
Mouse  1507 YADGL-WYRAKIISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIP 1550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965	4/22 (18%)
		TUDOR	454..510	CDD:197660	4/8 (50%)
		TUDOR	591..707	CDD:278965	26/137 (19%)
		TUDOR	644..693	CDD:197660	8/49 (16%)
		TUDOR	1012..1132	CDD:278965	36/173 (21%)
		TUDOR	1062..1119	CDD:197660	18/103 (17%)
		TUDOR	1309..1425	CDD:278965	31/122 (25%)
		TUDOR	1354..1411	CDD:197660	18/61 (30%)
		TUDOR	1614..1727	CDD:278965	26/123 (21%)
		TUDOR	1666..1711	CDD:119391	11/54 (20%)
		TUDOR	1791..1906	CDD:278965	31/146 (21%)
		TUDOR	1843..1886	CDD:119391	10/42 (24%)
		TUDOR	1975..2089	CDD:278965	30/125 (24%)
		TUDOR	2028..2069	CDD:119391	13/44 (30%)
		TUDOR	2159..2277	CDD:278965
		TUDOR	2210..2264	CDD:197660
		TUDOR	2345..2458	CDD:278965
		TUDOR	2396..2437	CDD:119391
Rnf17	NP_001028215.1	iSH2_PI3K_IA_R	158..>242	CDD:304922	16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..376		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435		7/91 (8%)
		TUDOR	444..>551	CDD:278965	22/112 (20%)
		TUDOR	698..819	CDD:278965	32/127 (25%)
		TUDOR	755..801	CDD:119391	18/46 (39%)
		TUDOR	937..1053	CDD:278965	27/131 (21%)
		TUDOR	990..1036	CDD:119391	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191		4/20 (20%)
		TUDOR	1196..1312	CDD:278965	27/131 (21%)
		TUDOR	1250..1295	CDD:119391	12/57 (21%)
		TUDOR	1426..1567	CDD:278965	32/131 (24%)
		TUDOR	1501..1548	CDD:119391	14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810