DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and SND1

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	NP_055205.2	Gene:	SND1 / 27044	HGNCID:	30646	Length:	910	Species:	Homo sapiens

Alignment Length:	865	Identity:	173/865 - (20%)
Similarity:	287/865 - (33%)	Gaps:	286/865 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1705 DATDIKESMWSHIEPFCLPCALPIRPK--GTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSY 1767
            ||.|..:      ||:..|....:|.|  |........|        |.|      ||..|...|
Human    69 DAKDTPD------EPWAFPAREFLRKKLIGKEVCFTIEN--------KTP------QGREYGMIY 113

  Fly  1768 VNMYIDGEDVAKKLIADGFA----------------------------------------RPLEY 1792
            :....:||::|:.|:|:|.|                                        |.|:|
Human   114 LGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTIRDLKY 178

  Fly  1793 LASGCSCYI-SH----VNGICDFFIQLERDS---KALELIELYL--------------RKKDTLK 1835
            .......:: ||    ||.|    |:..||.   :||.|.:.||              |:.|..:
Human   179 TIENPRHFVDSHHQKPVNAI----IEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSE 239

  Fly  1836 PLEGFEKGLIVAALFEDDELWYR-AQLQKELPDSRYEVLFIDYGNTSTTSKCLMLSEEIASLPSL 1899
            ..|.|   ...|..|.:..|..| .|:..|...::..:..|.:.|.:.|.  |:|.|..|
Human   240 TPEPF---AAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITE--LLLKEGFA----- 294

  Fly  1900 SKKCSLQLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENIIDRLLPLC 1964
              :|        :.||.....:.||.....|.....:.|:..:|:|.....||
Human   295 --RC--------VDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLD------------ 337

  Fly  1965 QRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKD----SLMDIICEKLNGSKLQPKTEK-A 2024
             :|:.:..:|          :..|.|...|.::.:..|    .|..|...:|.|...|.|.:| .
Human   338 -QKDKQFVAK----------VMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGENTQDKNKKLR 391

  Fly  2025 AVDDMCVVQFADDLEFYRSRILEVLEDDQYKV-ILIDYGNTTVVDKLYELPQEFTLIKPVAEICS 2088
            .:.|  :....:..||.|.:::      ..|| :.:||                  |:|.:....
Human   392 PLYD--IPYMFEAREFLRKKLI------GKKVNVTVDY------------------IRPASPATE 430

  Fly  2089 MEPSAIFEKNKALTLTTFDALLDSCKGV-VAVEFVNKSASPPVVRLTTKDKRSLKIYEHLQKLVQ 2152
            ..|:  |.:....|:|        ..|: :|...|:|..:..:......|:||    .|..:|:.
Human   431 TVPA--FSERTCATVT--------IGGINIAEALVSKGLATVIRYRQDDDQRS----SHYDELLA 481

  Fly  2153 AELKLIQ---------------------------------KRNENSECIISYGNSPKSFYVQMKH 2184
            ||.:.|:                                 :|...||.::.|..|.....:.:..
Human   482 AEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPK 546

  Fly  2185 NSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYG 2249
            .:.   ||...|..::..:..:.: |.....|..:|:|...:.:   :.||......||..:|..
Human   547 ETC---LITFLLAGIECPRGARNL-PGLVQEGEPFSEEATLFTK---ELVLQREVEVEVESMDKA 604

  Fly  2250 NTLVVPEVWQLPQEIEPIPSLALHCQLSKIPM---------------DVSDEKLEEAFAALLEQH 2299
            ...:   .| |..:...:..|.:...|||:..               :.:.:|.|:.:|     |
Human   605 GNFI---GW-LHIDGANLSVLLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWA-----H 660

  Fly  2300 FGELYEITTQPNEDETKPLIAELR--INYKD-FVQELVSTVTGVQKPLEAELHNCVVVQFDGPMS 2361
            :.|      ||.| |..|::.|..  .:||. ||.|:..           :||
Human   661 YEE------QPVE-EVMPVLEEKERSASYKPVFVTEITD-----------DLH------------ 695

  Fly  2362 FYVQMESDVPALEQMTDKLLDAEQDLPAFSDL------KEGALCVAQFPEDEVFYRAQIRKVLDD 2420
            ||||   ||....|:...:.:...|:.:...:      :.|..|:|:|.:.| :|||::.||...
Human   696 FYVQ---DVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFVDGE-WYRARVEKVESP 756

  Fly  2421 GKCEVHFIDFGNNAVTQQFR 2440
            .|..|.:||:||..|....|
Human   757 AKIHVFYIDYGNREVLPSTR 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965
		TUDOR	454..510	CDD:197660
		TUDOR	591..707	CDD:278965
		TUDOR	644..693	CDD:197660
		TUDOR	1012..1132	CDD:278965
		TUDOR	1062..1119	CDD:197660
		TUDOR	1309..1425	CDD:278965
		TUDOR	1354..1411	CDD:197660
		TUDOR	1614..1727	CDD:278965	6/21 (29%)
		TUDOR	1666..1711	CDD:119391	3/5 (60%)
		TUDOR	1791..1906	CDD:278965	32/137 (23%)
		TUDOR	1843..1886	CDD:119391	9/43 (21%)
		TUDOR	1975..2089	CDD:278965	21/119 (18%)
		TUDOR	2028..2069	CDD:119391	8/41 (20%)
		TUDOR	2159..2277	CDD:278965	20/150 (13%)
		TUDOR	2210..2264	CDD:197660	11/53 (21%)
		TUDOR	2345..2458	CDD:278965	28/102 (27%)
		TUDOR	2396..2437	CDD:119391	17/40 (43%)
SND1	NP_055205.2	SNc	21..166	CDD:214615	23/116 (20%)
		SNc	26..166	CDD:238102	23/116 (20%)
		SNc	193..328	CDD:214615	35/158 (22%)
		SNc	201..328	CDD:238102	31/146 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	321..325		1/3 (33%)
		SNc	341..495	CDD:214615	38/203 (19%)
		SNc	350..496	CDD:238102	37/185 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	388..392		1/3 (33%)
		SNc	525..660	CDD:214615	25/150 (17%)
		SNc	533..660	CDD:238102	23/142 (16%)
		TUDOR	677..799	CDD:278965	33/127 (26%)
		TUDOR	728..784	CDD:197660	18/50 (36%)
		SNc	<844..895	CDD:294094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810