DRSC/TRiP Functional Genomics Resources

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Protein Alignment tud and TDRD6

DIOPT Version :9

Sequence 1:NP_476773.1 Gene:tud / 37417 FlyBaseID:FBgn0003891 Length:2515 Species:Drosophila melanogaster
Sequence 2:NP_001010870.1 Gene:TDRD6 / 221400 HGNCID:21339 Length:2096 Species:Homo sapiens


Alignment Length:2495 Identity:486/2495 - (19%)
Similarity:857/2495 - (34%) Gaps:824/2495 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 PSRPLNADAPDYTPK-----------------HLPLVNVTNVQVQMPGLNNTQKPVFVSTNPYNR 317
            |.:...|||.|:...                 .|.|:.|.:|..||..|...::           
Human   146 PPQHWPADAVDFLSNLQGKEVHGCVLDVLLLHRLVLLEVPDVFQQMRELGLARR----------- 199

  Fly   318 ANYQPAVPAAQPYVPKANPRSQYTYYNVRMNKPINAMPPPAGPHVPIQHFNQQANNVSLSYVPAR 382
                         ||.:..||....|       :.|.....|..||:           ||.||  
Human   200 -------------VPDSLFRSLLERY-------LTAATASVGSGVPV-----------LSRVP-- 231

  Fly   383 FTPPPTPSIAQHQIPIPAFRTTSLTVGLTYDVVISYVENGPYLFWVHLKSSD---HDLSTMMGQI 444
                    :.|.|..:..| ...|.:|:|..|||:.|.: |:.....|:|..   |.||..|.|:
Human   232 --------LKQKQPGLDYF-YPQLQLGVTEAVVITQVCH-PHRIHCQLRSVSQEIHRLSESMAQV 286

  Fly   445 ER------------TKLKALAQAPEL-GTACVARFSEDGHLYRAMVCAVY-AQR-YRVVYVDYGN 494
            .|            ...:...::|:. |:.| |....|||.|||::...: .|| .:|::||||.
Human   287 YRGSTGTGDENSTSATWEEREESPDKPGSPC-ASCGLDGHWYRALLLETFRPQRCAQVLHVDYGR 350

  Fly   495 SELLSASDLFQIPPELLEIKPFAFRFALAG---------TKEIEPIDDSM--KRIFKKSAIYRNF 548
            .||:|.|.|..:.||...:....:..||.|         ..::..:...:  |.:..|...|.:|
Human   351 KELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKTLILGKAVNAKIEFYCSF 415

  Fly   549 E----LTVQAPESVG-----SMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLEND-------- 596
            |    :::...:.:.     .:|:|.|............:...:.||...||:::.:        
Human   416 EHVYYVSLYGEDGINLNRVFGVQSCCLADRVLQSQATEEEEPETSQSQSPAEEVDEEISLPALRS 480

  Fly   597 ---------DAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRV--------PDQLIL 644
                     || ::.|:.:||.|:::...:...|.:||..|..:|::..::        ||.|  
Human   481 IRLKMNAFYDA-QVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPDDL-- 542

  Fly   645 GAPCIVKCDQE-WYRAEILRVDD-SVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCL-- 705
               |.||..:. :|||.:.::|| ||.|..||.|..:||..:.:..:..:..::|..|:||.|  
Human   543 ---CCVKWKENGYYRAIVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLAD 604

  Fly   706 -----KGFENSELSEDKITDQFEMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLY 765
                 |.:....:|..|.|           :..:...:.|.. :.|...|:.:|.::        
Human   605 IWPLGKTWSQEAVSFFKKT-----------VLHKELVIHILD-KQDHQYVIEILDES-------- 649

  Fly   766 KLSMPFEQYLSLEKGQFNANNTRAESVISS----ELNKSHILNSTSIGETENRLQEQEKEQQQKK 826
                        ..|:.|.:...|::..:.    |..::.::|:.|.|...|....:..      
Human   650 ------------RTGEENISKVIAQAGYAKYQEFETKENILVNAHSPGHVSNHFTTESN------ 696

  Fly   827 VDVRQQQLAVEIPQAVKSVSGSKNSTDWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQST 891
                      :||.|                 .|..|.:.:||:.:                  |
Human   697 ----------KIPFA-----------------KTGEGEQKAKRENK------------------T 716

  Fly   892 GSYSSGMSSPRKGNRQQNGRTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQG 956
            .|.|..:|..   ....||.|.:      ..||..|.|..                         
Human   717 TSVSKALSDT---TVVTNGSTEL------VVQEKVKRASV------------------------- 747

  Fly   957 YAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAAS 1021
            |....|.......|: |||....|||.:    ...|:..:...|........:|.:||       
Human   748 YFPLMQNCLEIKPGS-SSKGELEVGSTV----EVRVSYVENPGYFWCQLTRNIQGLKT------- 800

  Fly  1022 LSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTA 1086
               .:|..|:|.  |:.:|.:              |...|......||   .|:.:..|.:.:.:
Human   801 ---LMSDIQYYC--KNTAAPH--------------QRNTLACLAKRTV---NRQWSRALISGIQS 843

  Fly  1087 CNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVVTNYDPLYIVDRMETFV 1151
            ..|:    .|..||.|....|:.::|:.:.:.|......|.|||.::::.               
Human   844 VEHV----NVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQ--------------- 889

  Fly  1152 PVNAKVDCEFVSKEKSNQGSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQ 1216
            ||...   .||...|:.|..|.          |::.|..:::            |::..:.|...
Human   890 PVGQN---PFVWDVKAIQAFNE----------FIDNAWQKNL------------ELKCTIFALAS 929

  Fly  1217 IRGKFTSIRD-MTSFKVQFDYGNNVNFLCTYDDAKFVK------SNPNLARRFKEFYEGKSFALN 1274
            |..:..:|.| :|.|:      :..:||.....|:.||      |:..|...|...::.|     
Human   930 INEELFNIVDLLTPFQ------SACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDMK----- 983

  Fly  1275 VKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQAIVPSMQTLL 1339
               :....:|::..:     :|..:|.|              ..|:...:..|....:..:..:|
Human   984 ---IGSEELVYITHI-----DDPWTFYC--------------QLARNANILEQLSCSITQLSKVL 1026

  Fly  1340 DNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDI 1404
            .|:         .....:.|.:|..:.:||||||..:..|:..    :||::|:||...:..||:
Human  1027 LNL---------KTSPLNPGTLCLAKYTDGNWYRGIVIEKEPK----KVFFVDFGNIYVVTSDDL 1078

  Fly  1405 KALDAKFYEHASGFAVEINLPIGRPSNDTKLKARISEILEEKVVTIKSIEVRRSHLIADVILENN 1469
            ..:.:..|:       .:.||:      ..::..:|:|.:              |:..:|::...
Human  1079 LPIPSDAYD-------VLLLPM------QAVRCSLSDIPD--------------HIPEEVVVWFQ 1116

  Fly  1470 QSVID-LLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLT--------LDEEEDKGRKETVS 1525
            ::::| .|||  ||..||.|        |......|.:.:.::        |...:|:.||:...
Human  1117 ETILDKSLKA--LVVAKDPD--------GTLIIELYGDNIQISASINKKLGLLSYKDRIRKKESE 1171

  Fly  1526 KSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVE 1590
            ...|...:.::|..|.|          .|......:.|..|.|:                .|::|
Human  1172 VLCSTTETLEEKNENMK----------LPCTEYLSKSVGYKLPN----------------KEILE 1210

  Fly  1591 ---VPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQL------ 1646
               .|:||.:                 ||:|..                :..|:|.|.:      
Human  1211 ESYKPQINSS-----------------YKELKL----------------LQSLTKTNLVTQYQDS 1242

  Fly  1647 --HENLQIVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDI 1709
              ::|.| |.|...:....::....:....|:......||.|:              |..|    
Human  1243 VGNKNSQ-VFPLTTEKKEEISAETPLKTARVEATLSERKIGDS--------------CDKD---- 1288

  Fly  1710 KESMWSHIEPFCLPCALPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDG 1774
                            ||::                  :.:.|                      
Human  1289 ----------------LPLK------------------FCEFP---------------------- 1297

  Fly  1775 EDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTL----- 1834
                :|.|..||.         .:.|:||:|.:.||::||..|...:..:...|....|.     
Human  1298 ----QKTIMPGFK---------TTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYV 1349

  Fly  1835 -KPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTST--TSKCLMLSEEIASL 1896
             .||   ::|.::.|:|.:|.|||||.::::.|:....|.||||||.|.  |:|...|....|.|
Human  1350 GPPL---QRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAIL 1411

  Fly  1897 PSLSKKCSLQ---LPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENII- 1957
            |.|...||||   :||.  ..|.:....|::.|.|..:  ..:.:| .||...: :|.|...|| 
Human  1412 PGLCIHCSLQGFEVPDN--KNSKKMMHYFSQRTSEAAI--RCEFVK-FQDRWEV-ILADEHGIIA 1470

  Fly  1958 DRLL---PLCQRKEP-------KEASKESLAVT-----------------TKAIITHVENTSRIY 1995
            |.::   .|.::.:.       |.||.:|:..:                 .:|..|.::.....:
Human  1471 DDMISRYALSEKSQVELSTQVIKSASSKSVNKSDIDTSVFLNWYNPEKKMIRAYATVIDGPEYFW 1535

  Fly  1996 LQFSEKDSLMDIICEKLNGSKLQPKTEKAA----------VDDMCVVQFADDLEFYRSRILEVLE 2050
            .||::.:.|..:..|      :|...|:.|          :.|.|:|::.:|..:||:.|..:.|
Human  1536 CQFADTEKLQCLEVE------VQTAGEQVADRRNCIPCPYIGDPCIVRYREDGHYYRALITNICE 1594

  Fly  2051 DDQYKVILIDYGN-TTVVD--KLYELPQEFTLIKPVA------------EICSMEPSAIFEK--- 2097
            |....|.|:|:|| ...||  .|:.:|.|...:...|            .:||.|.:..|.:   
Human  1595 DYLVSVRLVDFGNIEDCVDPKALWAIPSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEIIT 1659

  Fly  2098 NKALTLTTFDALLDSCK---GVVAVEFVNKSASPPVVRLTTKDKRSLKIYEHLQKLVQAEL---- 2155
            ...|.:|..:...|.|.   .:|.::...||.:..:.:.:....:|...||::...::..|    
Human  1660 EDVLEITILEIRRDVCDIPLAIVDLKSKGKSINEKMEKYSKTGIKSALPYENIDSEIKQTLGSYN 1724

  Fly  2156 ------KLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNS 2214
                  ||..|..:|.              :.|:..:.:|..|.:...::...|.....||.|::
Human  1725 LDVGLKKLSNKAVQNK--------------IYMEQQTDELAEITEKDVNIIGTKPSNFRDPKTDN 1775

  Fly  2215 NGVCYSQEDACYYRCSIKS--------VLDPSQGFEVFLLDYGNTLVVPEVWQLP-----QEIEP 2266
              :|...|:.|..:...:.        ::|.::..:.:|:...|||       ||     :||..
Human  1776 --ICEGFENPCKDKIDTEELEGELECHLVDKAEFDDKYLITGFNTL-------LPHANETKEILE 1831

  Fly  2267 IPSLALHCQLSKIPMDVSDEKLEEAFAALLEQHFGELYEITTQPN--EDETKPLIAELRINYKDF 2329
            :.||       ::|:...||..|          |.||..|..|.:  .||.|..::.:..|. ..
Human  1832 LNSL-------EVPLSPDDESKE----------FLELESIELQNSLVVDEEKGELSPVPPNV-PL 1878

  Fly  2330 VQELVS----TVTGVQKPLEAELHNCVVVQFDGPMSFYVQMESDVPALEQMTDKLLD-------- 2382
            .||.|:    .:..:|.||..|...              |.|.::|..:...|..:|        
Human  1879 SQECVTKGAMELFTLQLPLSCEAEK--------------QPELELPTAQLPLDDKMDPLSLGVSQ 1929

  Fly  2383 AEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGK-------CEVHFIDFGN----NAVT 2436
            ..|:.....|:::.: ||..| :|:......:.....|.|       ||..|:::.|    :|:.
Human  1930 KAQESMCTEDMRKSS-CVESF-DDQRRMSLHLHGADCDPKTQNEMNICEEEFVEYKNRDAISALM 1992

  Fly  2437 QQFRQ------------LPEELAKPARYSRHCELDASTI-SKCDAALLQSFIDTRFSETFQVEIL 2488
            ..|.:            ||:.::  |:......|.|.|: |||   ::.|.:...:|   :.|||
Human  1993 PLFSEEESSDGSKHNNGLPDHIS--AQLQNTYTLKAFTVGSKC---VVWSSLRNTWS---KCEIL 2049

  Fly  2489 ATKGTGTHVVRLFYQSKNISEKLQE 2513
            .|...||.|:       |:|..::|
Human  2050 ETAEEGTRVL-------NLSNGMEE 2067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tudNP_476773.1 DUF1421 198..>397 CDD:284607 27/143 (19%)
TUDOR 406..524 CDD:278965 42/135 (31%)
TUDOR 454..510 CDD:197660 23/58 (40%)
TUDOR 591..707 CDD:278965 36/149 (24%)
TUDOR 644..693 CDD:197660 16/50 (32%)
TUDOR 1012..1132 CDD:278965 25/119 (21%)
TUDOR 1062..1119 CDD:197660 11/56 (20%)
TUDOR 1309..1425 CDD:278965 21/115 (18%)
TUDOR 1354..1411 CDD:197660 16/56 (29%)
TUDOR 1614..1727 CDD:278965 16/120 (13%)
TUDOR 1666..1711 CDD:119391 6/44 (14%)
TUDOR 1791..1906 CDD:278965 40/122 (33%)
TUDOR 1843..1886 CDD:119391 19/44 (43%)
TUDOR 1975..2089 CDD:278965 31/155 (20%)
TUDOR 2028..2069 CDD:119391 16/43 (37%)
TUDOR 2159..2277 CDD:278965 23/130 (18%)
TUDOR 2210..2264 CDD:197660 12/66 (18%)
TUDOR 2345..2458 CDD:278965 23/143 (16%)
TUDOR 2396..2437 CDD:119391 11/51 (22%)
TDRD6NP_001010870.1 TUDOR <69..133 CDD:278965
TUDOR 246..380 CDD:278965 42/135 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..316 3/28 (11%)
TUDOR 314..360 CDD:119391 20/46 (43%)
TUDOR 483..604 CDD:278965 35/126 (28%)
TUDOR 541..585 CDD:119391 17/48 (35%)
TUDOR 770..886 CDD:278965 31/152 (20%)
TUDOR 821..866 CDD:119391 11/51 (22%)
TUDOR 982..1102 CDD:278965 28/172 (16%)
TUDOR 1037..1080 CDD:119391 16/46 (35%)
TUDOR 1301..1422 CDD:278965 44/132 (33%)
TUDOR 1356..1401 CDD:119391 19/44 (43%)
TUDOR 1516..1638 CDD:278965 29/127 (23%)
TUDOR 1571..>1609 CDD:119391 14/37 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149518
Domainoid 1 1.000 69 1.000 Domainoid score I9682
eggNOG 1 0.900 - - E1_COG1525
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 130 1.000 Inparanoid score I4652
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232447at33208
OrthoFinder 1 1.000 - - FOG0002918
OrthoInspector 1 1.000 - - otm41754
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22948
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4796
SonicParanoid 1 1.000 - - X4998
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.930

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