DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tud and Tdrd5

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	NP_001128213.1	Gene:	Tdrd5 / 214575	MGIID:	2684949	Length:	1040	Species:	Mus musculus

Alignment Length:	1067	Identity:	208/1067 - (19%)
Similarity:	343/1067 - (32%)	Gaps:	345/1067 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 SIHNSKTPMEIAREQLAV------------RQSLAARLDAQRSVQVTPSRP----LNADAPDYTP 283
            |..:..||.::.:|.|.:            |.::...||....|.|.|...    |.| .||.:.
Mouse    21 STKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPGGDGTVILKA-IPDEST 84

  Fly   284 KHLPLVNVTNVQVQMPGLNNTQ---KPVFVSTNPYNRANYQPAVPAAQPYVPKANPRS------- 338
            |  .:.::...|.:...:.|:.   :|...|    .|..|:..||...|.|.|:..:.
Mouse    85 K--GIASLVAKQRRSHKVRNSMPKGRPSICS----GRVPYRGRVPPILPAVVKSELKDLLALSPV 143

  Fly   339 -----------------QYTYYN-VRMNKPINAMPP---------------------------PA 358
                             ||..|. :.|.:.:||...                           ||
Mouse   144 LLSDFEKAFARRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLTLKKSVSEDKQRGWPA 208

  Fly   359 G----------------PHVPIQ--HFNQQANNVSLSYVPARFTPPPTPSIAQHQIP----IPAF 401
            |                ...|:.  ||:|..:|:.          ||...::..:.|    :.|.
Mouse   209 GKVFTQPFRMKQQGSYSTGFPVMKAHFSQPISNME----------PPKQVLSMAKTPTFNSVEAS 263

  Fly   402 R---TTSLT-VGLTYDVVISYVENG----PYL-----FWVHLKSSDHDLSTMMGQIERTKLKALA 453
            |   |..|. :..|:..||:.:..|    |.|     |.|........:|.::|:.|.| .|...
Mouse   264 RLNHTEKLNQLESTFKSVIAQIGPGGTVDPELKRKIQFVVSKFPQGLFISKLLGEFELT-FKEQL 327

  Fly   454 QAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQI-------PPELL 511
            ...:||...|....  |.|...:......:|..::..|.....|.|...|..:       |.:..
Mouse   328 SPKQLGFLNVTELV--GALSDILRVEFSEERQDLLVFDADLKPLPSGGPLSSVRNSCLVQPDKKT 390

  Fly   512 EIKPFAFRFA-----------------LAGTKEIEPIDDSMKRIFKK-SAIYRNFELTVQA---- 554
            |..|:....:                 |...||.|      ::|:|| :.:.:..:|.|:.
Mouse   391 EANPWTSSLSRNSLSTVAVKKTTWDCPLKNQKEPE------QKIYKKPNLVVKPLQLQVETNKPQ 449

  Fly   555 -----------PESVGSMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLENDDAVEIRFIDSPS 608
                       |::|.:.:.|.|....|:.|.                      .|.:.:|.|||
Mouse   450 LSLSVANHDIPPDAVRAKKLCRLPPLDTSTLV----------------------GVFVEYIISPS 492

  Fly   609 NFYVQKVANIGK--FEQLMDEMFSYYNANQRVPDQLIL-------GAPCIVKC--DQEWYRAEIL 662
            .||::..:....  .|.:|.||...| :||.|.|:.|:       |..|.||.  |:.|||..|.
Mouse   493 QFYIRIYSRDSSELLEDMMIEMRRCY-SNQLVSDRYIMPEYFIQPGHLCCVKISEDKWWYRVIIH 556

  Fly   663 RV--DDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSE------------- 712
            |:  ...|.|.:.|||....|::..:..:...:.::|.|||.|.|.....:|
Mouse   557 RILGKKEVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTARAILHFQK 621

  Fly   713 ---------LSEDKITDQFEMLAEESNIRRRTFSVRIFRIE-----------PDGLNVVNLLAKN 757
                     :.::.|.....:...:::.....:...:.|.|           ..|....|..|..
Mouse   622 LCGLKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNPPALY 686

  Fly   758 LNVMKK----LYKLSMPFEQ-YLS-----LEKGQFNANNTRAESVISS---ELNKSHILNSTSIG 809
            .|....    |..|..|.:| ||:     |::.|.:.|:.:..|.:.|   ||.|...|:|.
Mouse   687 TNASSAGDMVLTDLGHPAQQHYLNEDQEILQQAQQDINDGKCISYLKSAPKELLKDSKLSSL--- 748

  Fly   810 ETENRLQE-------QEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNSTD-WDKR------SST 860
            :|....:|       |.|:.:::..|        |:|..:..:.......| ||:.      ...
Mouse   749 KTHKSCEEDPRWSILQPKDLKEENED--------EVPTGMPCLESVTIGDDVWDENWLPLQAKMG 805

  Fly   861 SAGSKDS---------KRQQQQ--QIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPI 914
            .|||..|         |:|.|.  ::.:.|.....|.:.........|:::..||..    .||
Mouse   806 KAGSPASQLFTSNLVGKKQYQTGGEMAQKDWCFSTSKDIWDDSWQPLGLANDVKGGI----HTP- 865

  Fly   915 QSPRHNEK--------QEAKKNARFSNSESPRRSR------DGQQGNQRSQNAPQGYAQKPQRQK 965
            :.|...||        |:........:|..|:...      ..||..:|||:.|........|..
Mouse   866 EGPIAQEKNTSTTRIQQQPDLQYPLDSSTLPKLEEFYISLIKSQQSAERSQSEPASIQTHAGRAA 930

  Fly   966 STL--------------DGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPS 1016
            |..              .|::.|...|....|:::|.:|  |.||.:...::|:
Mouse   931 SKALSSTPAVGDSPENHSGSVESSPGSLKKEDVSNSRAE--ATAKDKSQGAIDQ----------- 982

  Fly  1017 KEAASLSWWLSP----FQFYIVPKSVS 1039
                 ||:.|||    .|...:|:|.:
Mouse   983 -----LSFILSPQHQISQKLYIPRSTA 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607	43/250 (17%)
		TUDOR	406..524	CDD:278965	28/151 (19%)
		TUDOR	454..510	CDD:197660	11/62 (18%)
		TUDOR	591..707	CDD:278965	39/128 (30%)
		TUDOR	644..693	CDD:197660	16/59 (27%)
		TUDOR	1012..1132	CDD:278965	8/32 (25%)
		TUDOR	1062..1119	CDD:197660
		TUDOR	1309..1425	CDD:278965
		TUDOR	1354..1411	CDD:197660
		TUDOR	1614..1727	CDD:278965
		TUDOR	1666..1711	CDD:119391
		TUDOR	1791..1906	CDD:278965
		TUDOR	1843..1886	CDD:119391
		TUDOR	1975..2089	CDD:278965
		TUDOR	2028..2069	CDD:119391
		TUDOR	2159..2277	CDD:278965
		TUDOR	2210..2264	CDD:197660
		TUDOR	2345..2458	CDD:278965
		TUDOR	2396..2437	CDD:119391
Tdrd5	NP_001128213.1	LOTUS_1_TDRD5	4..98	CDD:193599	17/79 (22%)
		LOTUS_2_TDRD5	127..196	CDD:193589	9/68 (13%)
		LOTUS_3_TDRD5	292..365	CDD:193590	16/75 (21%)
		TUDOR	483..602	CDD:278965	38/119 (32%)
		TUDOR	537..583	CDD:119391	16/45 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..891		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..975		15/64 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900