Protein Alignment tud and Tdrd5

DIOPT Version :10

• Sequence 1: NP_476773.1
• Gene: tud / 37417
• FlyBaseID: FBgn0003891
• Length: 2515
• Species: Drosophila melanogaster
• Sequence 2: NP_001128213.1
• Gene: Tdrd5 / 214575
• MGIID: 2684949
• Length: 1040
• Species: Mus musculus
• Alignment Length: 1067
• Identity: 208/1067 - (19%)
• Similarity: 343/1067 - (32%)
• Gaps: 345/1067 - (32%)

  Fly   235 SIHNSKTPMEIAREQLAV------------RQSLAARLDAQRSVQVTPSRP----LNADAPDYTP 283
            |..:..||.::.:|.|.:            |.::...||....|.|.|...    |.| .||.:.
Mouse    21 STKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPGGDGTVILKA-IPDEST 84

  Fly   284 KHLPLVNVTNVQVQMPGLNNTQ---KPVFVSTNPYNRANYQPAVPAAQPYVPKANPRS------- 338
            |  .:.::...|.:...:.|:.   :|...|    .|..|:..||...|.|.|:..:.
Mouse    85 K--GIASLVAKQRRSHKVRNSMPKGRPSICS----GRVPYRGRVPPILPAVVKSELKDLLALSPV 143

  Fly   339 -----------------QYTYYN-VRMNKPINAMPP---------------------------PA 358
                             ||..|. :.|.:.:||...                           ||
Mouse   144 LLSDFEKAFARRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLTLKKSVSEDKQRGWPA 208

  Fly   359 G----------------PHVPIQ--HFNQQANNVSLSYVPARFTPPPTPSIAQHQIP----IPAF 401
            |                ...|:.  ||:|..:|:.          ||...::..:.|    :.|.
Mouse   209 GKVFTQPFRMKQQGSYSTGFPVMKAHFSQPISNME----------PPKQVLSMAKTPTFNSVEAS 263

  Fly   402 R---TTSLT-VGLTYDVVISYVENG----PYL-----FWVHLKSSDHDLSTMMGQIERTKLKALA 453
            |   |..|. :..|:..||:.:..|    |.|     |.|........:|.::|:.|.| .|...
Mouse   264 RLNHTEKLNQLESTFKSVIAQIGPGGTVDPELKRKIQFVVSKFPQGLFISKLLGEFELT-FKEQL 327

  Fly   454 QAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQI-------PPELL 511
            ...:||...|....  |.|...:......:|..::..|.....|.|...|..:       |.:..
Mouse   328 SPKQLGFLNVTELV--GALSDILRVEFSEERQDLLVFDADLKPLPSGGPLSSVRNSCLVQPDKKT 390

  Fly   512 EIKPFAFRFA-----------------LAGTKEIEPIDDSMKRIFKK-SAIYRNFELTVQA---- 554
            |..|:....:                 |...||.|      ::|:|| :.:.:..:|.|:.
Mouse   391 EANPWTSSLSRNSLSTVAVKKTTWDCPLKNQKEPE------QKIYKKPNLVVKPLQLQVETNKPQ 449

  Fly   555 -----------PESVGSMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLENDDAVEIRFIDSPS 608
                       |::|.:.:.|.|....|:.|.                      .|.:.:|.|||
Mouse   450 LSLSVANHDIPPDAVRAKKLCRLPPLDTSTLV----------------------GVFVEYIISPS 492

  Fly   609 NFYVQKVANIGK--FEQLMDEMFSYYNANQRVPDQLIL-------GAPCIVKC--DQEWYRAEIL 662
            .||::..:....  .|.:|.||...| :||.|.|:.|:       |..|.||.  |:.|||..|.
Mouse   493 QFYIRIYSRDSSELLEDMMIEMRRCY-SNQLVSDRYIMPEYFIQPGHLCCVKISEDKWWYRVIIH 556

  Fly   663 RV--DDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSE------------- 712
            |:  ...|.|.:.|||....|::..:..:...:.::|.|||.|.|.....:|
Mouse   557 RILGKKEVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTARAILHFQK 621

  Fly   713 ---------LSEDKITDQFEMLAEESNIRRRTFSVRIFRIE-----------PDGLNVVNLLAKN 757
                     :.::.|.....:...:::.....:...:.|.|           ..|....|..|..
Mouse   622 LCGLKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNPPALY 686

  Fly   758 LNVMKK----LYKLSMPFEQ-YLS-----LEKGQFNANNTRAESVISS---ELNKSHILNSTSIG 809
            .|....    |..|..|.:| ||:     |::.|.:.|:.:..|.:.|   ||.|...|:|.
Mouse   687 TNASSAGDMVLTDLGHPAQQHYLNEDQEILQQAQQDINDGKCISYLKSAPKELLKDSKLSSL--- 748

  Fly   810 ETENRLQE-------QEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNSTD-WDKR------SST 860
            :|....:|       |.|:.:::..|        |:|..:..:.......| ||:.      ...
Mouse   749 KTHKSCEEDPRWSILQPKDLKEENED--------EVPTGMPCLESVTIGDDVWDENWLPLQAKMG 805

  Fly   861 SAGSKDS---------KRQQQQ--QIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPI 914
            .|||..|         |:|.|.  ::.:.|.....|.:.........|:::..||..    .||
Mouse   806 KAGSPASQLFTSNLVGKKQYQTGGEMAQKDWCFSTSKDIWDDSWQPLGLANDVKGGI----HTP- 865

  Fly   915 QSPRHNEK--------QEAKKNARFSNSESPRRSR------DGQQGNQRSQNAPQGYAQKPQRQK 965
            :.|...||        |:........:|..|:...      ..||..:|||:.|........|..
Mouse   866 EGPIAQEKNTSTTRIQQQPDLQYPLDSSTLPKLEEFYISLIKSQQSAERSQSEPASIQTHAGRAA 930

  Fly   966 STL--------------DGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPS 1016
            |..              .|::.|...|....|:::|.:|  |.||.:...::|:
Mouse   931 SKALSSTPAVGDSPENHSGSVESSPGSLKKEDVSNSRAE--ATAKDKSQGAIDQ----------- 982

  Fly  1017 KEAASLSWWLSP----FQFYIVPKSVS 1039
                 ||:.|||    .|...:|:|.:
Mouse   983 -----LSFILSPQHQISQKLYIPRSTA 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	TUDOR	411..524	CDD:425754	27/145 (19%)
		TUDOR	595..707	CDD:425754	39/124 (31%)
		TUDOR	1016..1132	CDD:425754	8/28 (29%)
		TUDOR	1309..1425	CDD:425754
		TUDOR	1620..1727	CDD:425754
		TUDOR	1795..1906	CDD:425754
		TUDOR	1980..2089	CDD:425754
		TUDOR	2163..2277	CDD:425754
		TUDOR	2347..2458	CDD:425754
Tdrd5	NP_001128213.1	LOTUS_1_TDRD5	4..98	CDD:193599	17/79 (22%)
		LOTUS_2_TDRD5	127..196	CDD:193589	9/68 (13%)
		LOTUS_3_TDRD5	292..365	CDD:193590	16/75 (21%)
		Tudor_TDRD5	484..601	CDD:410490	37/117 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..891		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	912..975		15/64 (23%)